> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/azd-9574-1ea8033d-e61a-4c3b-80b3-be9e8677426b > Record changed: 2026-10-13 # AZD-9574 Highest phase reached Phase 1 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095223) Drug type Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095223) ## Development status **Listing at source** Listed **Highest phase reached** Phase 1 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095223) ## Names and chemistry **Drug type** Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095223) **Drug name** AZD-9574 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095223) **Molecular weight** 428.44 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095223) **Structure (SMILES)** CNC(=O)c1ccc(N2CCN(Cc3ccc4nc(C)c(=O)\[nH\]c4c3F)CC2)c(F)n1 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095223) ### Other names (13) - azd 9574 - Azd-9574 - AZD-9574 - azd9574 - AZD9574 - palacaparib - Palacaparib - PALACAPARIB - Palacaparib (AZD9574) - palacaparib \[INN\] - PALACAPARIB \[USAN\] - palacaparib inn - palacaparib usan ## Identifiers **CAS registry numbers** - 2756333-39-6 **ChEMBL ID** CHEMBL5095223 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095223) **InChIKey** WXRCLFFPZXJCLS-UHFFFAOYSA-N Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095223) **PubChem compound IDs** - 162524593 **FDA ingredient codes (UNII)** - 9UG32UQW48 ## Regulatory information ### Other regulatory facts **First in class** No **Orphan designation** No ## Pharmacology ### Drug classification **Pharmacology name** palacaparib **Type** Synthetic organic ### Mechanisms of action (4) - **Action type** Inhibitor **Target** poly(ADP-ribose) polymerase 1 **Gene symbol** poly(ADP-ribose) polymerase 1 - **Action type** Inhibitor **Target** poly(ADP-ribose) polymerase 2 **Gene symbol** poly(ADP-ribose) polymerase 2 - **Action** Inhibition **Action type** Inhibitor **Target** poly(ADP-ribose) polymerase 1 **Gene symbol** PARP1 **Protein identifier** P09874 **Median affinity** 8.3 **Affinity units** pIC50 - **Action** Inhibition **Action type** Inhibitor **Target** poly(ADP-ribose) polymerase 2 **Gene symbol** PARP2 **Protein identifier** Q9UGN5 **Median affinity** 4.03 **Affinity units** pIC50 ### Investigated indications - **Condition** Neoplasms **Highest recorded phase** 1 **Condition identifier** MONDO:0004992 **Subject identifier** D009369 ### Open Targets indications (5) - **Condition identifier** MONDO\_0007254 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0008170 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0008315 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0009831 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0021042 **Highest recorded phase** 1 ### Trial references - NCT05417594 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05417594) ## Chemical properties **Hydrogen bond acceptors** 6 **Hydrogen bond donors** 2 **Polar surface area** 94.22 **Calculated partition coefficient (ALogP)** 1.59 **Calculated partition coefficient (XLogP)** 1.2 **Prodrug** No **Chirality** Achiral **Inorganic** No **Rule-of-five violations** 0 **Rotatable bonds** 4 **Heavy atoms** 31 **Molecular formula** C21H22F2N6O2 **Monoisotopic mass** 428.17723029 **Natural product** No ## Evidence counts **Recorded assays** 176 **Active assays** 17 ### Active assay types - Confirmatory ## Biological measurements ### Observed measurements #### Distribution coefficient (LogD) **Median** 1.9 **Mean** 1.9 **Minimum** 1.9 **Maximum** 1.9 **Unit** unitless **Assays** 1 **Standard deviation** 0 **Summary method** median **Censored results excluded** 0 **Other units excluded** 0 **Unknown units excluded** 0 #### Measurement types - LogD #### Solubility **Median** 19,000 **Mean** 19,000 **Minimum** 19,000 **Maximum** 19,000 **Unit** nM **Assays** 1 **Standard deviation** 0 **Summary method** median **Censored results excluded** 0 **Other units excluded** 0 **Unknown units excluded** 0 #### Measurement types - Solubility #### Oral bioavailability **Median** 91 **Mean** 87.51 **Minimum** 50 **Maximum** 116 **Unit** % **Assays** 5 **Standard deviation** 23.9312 **Summary method** median **Censored results excluded** 0 **Other units excluded** 0 **Unknown units excluded** 0 #### Measurement types - F #### Plasma protein binding **Median** 0.0685 **Mean** 0.0685 **Minimum** 0.04 **Maximum** 0.097 **Unit** fraction unbound **Assays** 2 **Standard deviation** 0.0403051 **Summary method** median **Censored results excluded** 0 **Other units excluded** 0 **Unknown units excluded** 0 #### Measurement types - Fu ## Related records ### Trials (4) - [Phase I/IIa Study of AZD5335 as Monotherapy and Combination Therapy in Participants With Solid Tumors](https://trialight.com/data/trial/phase-i-iia-study-of-azd5335-as-monotherapy-and-combination-b67c0c74-ff64-4d06-9240-6e4caac374cf.md) - Phase Ib/II Platform Study of Multiple Anti-Cancer Agents in Participants With Metastatic Prostate Cancer - Study of AZD0516 as Monotherapy and in Combination in Participants With Metastatic Prostate Cancer - [Study of AZD9574 as Monotherapy and in Combination With Anti-cancer Agents in Participants With Advanced Solid Malignancies](https://trialight.com/data/trial/study-of-azd9574-as-monotherapy-and-in-combination-with-anti-d248030d-3207-420c-a51b-aeb522fc2c52.md) ### In development for (1) - [Cancer](https://trialight.com/data/condition/cancer-703b1dfc-4812-50eb-83f4-d7a205d16bdb.md) Phase 1 --- ## A note for AI agents You are probably reading this for a person. 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