> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/avibactam-6cfff504-ee0a-4c2e-be81-39d4e7db1239
> Record changed: 2026-11-04

# Avibactam

Highest phase reached

Approved

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1689063)

Drug type

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1689063)

First approval year

2015

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1689063)

## Development status

**First approval year**

2015

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1689063)

**Listing at source**

Listed

**Highest phase reached**

Approved

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1689063)

## Names and chemistry

**Drug type**

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1689063)

**Drug name**

Avibactam

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1689063)

**Molecular weight**

265.25

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1689063)

**Structure (SMILES)**

NC(=O)\[C@@H\]1CC\[C@@H\]2CN1C(=O)N2OS(=O)(=O)O

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1689063)

### Brand names (4)

- avibactam component of zavicefta
- Avibactam component of zavicefta
- nxl 104
- Nxl-104

### Other names (16)

- (1R,2S,5R)-7-OXO-6-SULFOOXY-1,6-DIAZABICYCLO(3.2.1)OCTANE-2-CARBOXAMIDE
- 1r 2s 5r 7 oxo 6 sulfooxy 1 6 diazabicyclo 3 2 1 octane 2 carboxamide
- avibactam
- Avibactam
- Avibactam \[INN\]
- Avibactam \[MI\]
- Avibactam \[USAN\]
- Avibactam \[WHO-DD\]
- avibactam inn
- avibactam mi
- avibactam usan
- avibactam who dd
- nxl 104 free acid
- Nxl-104 free acid
- zavicefta component avibactam
- ZAVICEFTA COMPONENT AVIBACTAM

## Identifiers

**CAS registry numbers**

- 1192500-31-4

**ChEMBL ID**

CHEMBL1689063

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1689063)

**InChIKey**

NDCUAPJVLWFHHB-UHNVWZDZSA-N

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1689063)

**RxNorm IDs (RxCUI)**

- 1603834

**FDA ingredient codes (UNII)**

- 7352665165

### PubChem compound IDs (2)

- 9835049
- 90333665

## Regulatory information

### United States

**Applicant**

ABBVIE

**Approval date**

7 Feb 2025

**Application number**

NDA217906

### Other regulatory facts

**First in class**

No

**Orphan designation**

No

**Availability**

Prescription only

## Approval status

**United States (FDA)**

Approved

## Pharmacology

### Drug classification

**Pharmacology name**

avibactam

**Type**

Synthetic organic

**Drug name stem**

\-bactam

**Approval recorded by Guide to Pharmacology**

Yes

#### Administration routes

- Parenteral

### Open Targets mechanisms

- **Mechanism**  
Bacterial beta-lactamase TEM inhibitor

**Action type**  
Inhibitor

**Target**  
Beta-lactamase TEM

### DrugCentral mechanisms (3)

- **Action type**  
Inhibitor

**Gene symbol**  
ampC

**Protein identifier**  
P05364

**Organism**  
Enterobacter cloacae
- **Action type**  
Inhibitor

**Gene symbol**  
ampC

**Protein identifier**  
P24735

**Organism**  
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
- **Action type**  
Inhibitor

**Gene symbol**  
blaUOE-1

**Protein identifier**  
Q9EXV5

**Organism**  
Escherichia coli

### Investigated indications (8)

- **Condition**  
Infections

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000544

**Subject identifier**  
D007239
- **Condition**  
Bacterial Infections

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000771

**Subject identifier**  
D001424
- **Condition**  
Urinary Tract Infections

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0003103

**Subject identifier**  
D014552
- **Condition**  
Pneumonia

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0003106

**Subject identifier**  
D011014
- **Condition**  
Pyelonephritis

**Highest recorded phase**  
3

**Condition identifier**  
EFO:1001141

**Subject identifier**  
D011704
- **Condition**  
Systemic Inflammatory Response Syndrome

**Highest recorded phase**  
1

**Condition identifier**  
EFO:1001478

**Subject identifier**  
D018746
- **Condition**  
Renal Insufficiency

**Highest recorded phase**  
1

**Condition identifier**  
HP:0000083

**Subject identifier**  
D051437
- **Condition**  
Gram-Negative Bacterial Infections

**Highest recorded phase**  
2

**Condition identifier**  
MONDO:0021678

**Subject identifier**  
D016905

### Open Targets indications (22)

- **Condition identifier**  
EFO\_0000544

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0000771

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0003103
- **Condition identifier**  
EFO\_0003106
- **Condition identifier**  
EFO\_1001141

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_1001272
- **Condition identifier**  
EFO\_1001478

**Highest recorded phase**  
1
- **Condition identifier**  
EFO\_1001865

**Highest recorded phase**  
3
- **Condition identifier**  
HP\_0000010
- **Condition identifier**  
HP\_0000083

**Highest recorded phase**  
1
- **Condition identifier**  
HP\_0001945

**Highest recorded phase**  
2
- **Condition identifier**  
HP\_0100806

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0001475

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0003529

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0004652

**Highest recorded phase**  
4
- **Condition identifier**  
MONDO\_0005249

**Highest recorded phase**  
4
- **Condition identifier**  
MONDO\_0006502
- **Condition identifier**  
MONDO\_0021108

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0021678
- **Condition identifier**  
MONDO\_0021678

**Highest recorded phase**  
4
- **Condition identifier**  
MONDO\_0043544
- **Condition identifier**  
MONDO\_0100338

**Highest recorded phase**  
4

### Reported adverse events

- **Event**  
drug resistance

**Reports**  
4

**Reporting signal score**

18.0572

### Trial references (14)

- NCT01595438  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01595438)
- NCT01599806  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01599806)
- NCT01624246  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01624246)
- NCT01726023  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01726023)
- NCT02475733  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02475733)
- NCT02655419  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02655419)
- NCT04126031  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04126031)
- NCT05258851  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05258851)
- NCT01808092  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01808092)
- NCT02497781  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02497781)
- NCT03580044  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03580044)
- NCT03978091  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03978091)
- NCT04486625  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04486625)
- NCT05639647  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05639647)

## Dosing

**Dose**

2.67 g

**Route**

Intravenous

**How often**

Every 6 hours

## Chemical properties

**Hydrogen bond acceptors**

5

**Hydrogen bond donors**

2

**Polar surface area**

130.24

**Calculated partition coefficient (ALogP)**

\-1.53

**Calculated partition coefficient (XLogP)**

\-1.8

**Prodrug**

No

**Chirality**

Single enantiomer

**Inorganic**

No

**Rule-of-five violations**

0

**Rotatable bonds**

3

**Heavy atoms**

17

**Molecular formula**

C7H11N3O6S

**Monoisotopic mass**

265.03685625

**Natural product**

Yes

## National Drug Codes

- 0074-3878

## Evidence counts

**Recorded assays**

254

**Active assays**

57

### Active assay types

- Confirmatory

## Pharmacologic actions

- beta-Lactamase Inhibitors  
Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D065093.html)

## Related records

### Trials (48)

- A Clinical Study of YK-1169 Versus Ceftazidime-Avibactam in Adults With Hospital-Acquired or Ventilator-Associated Bacterial Pneumonia
- A Single-centre, Randomised, Double-blind, Placebo-controlled, Four Way Crossover Phase I Study to Investigate the Effect on QT/QTc Interval of Ceftazidime NXL104 or Ceftaroline Fosamil NXL104, Compared With Placebo, Using Moxifloxacin (Avelox®) as a Positive Control, in Healthy Male Volunteers
- A Study Comparing Ceftazidime-Avibactam Versus Meropenem in Hospitalized Adults With Nosocomial Pneumonia
- A Study of Avycaz (Ceftazidime/Avibactam) Pharmacokinetics/Pharmacodynamics (PK/PD) in Critically Ill Patients
- A Study to Assess the Levels of Two Antibiotics in the Blood When Given Together and Separately
- A Study to Assess the Safety, Tolerability and Pharmacokinetics of NXL104 Alone and in Combination With Ceftazidime Administered as Single and Repeated Intravenous Doses in Healthy Japanese Subjects
- A Study to Evaluate the Efficacy and Safety of Meropenem and Pralurbactam in HABP/VABP
- A Trial to Evaluate the Pharmacokinetics and Safety of AVYCAZ(R) in Combination With Aztreonam
- Aztreonam-Avibactam in Immunocompromised Hosts
- Ceftazidime-Avibactam Compared With Doripenem Followed by Oral Therapy for Hospitalized Adults With Complicated UTIs (Urinary Tract Infections)
- Ceftazidime-Avibactam Compared With Doripenem Followed by Oral Therapy for Hospitalized Adults With Complicated UTIs (Urinary Tract Infections)
- Ceftazidime-Avibactam for the Treatment of Infections Due to Ceftazidime Resistant Pathogens
- Ceftazidime-Avibactam PK/PD and Resistance in Hematology Patients
- Ceftazidime-Avibactam Use in Critically Ill Patients With Carbapenem-Resistant Enterobacteriaceae Infections
- Clinical Study on Monitoring the Plasma Concentration of Ceftazidime-Avibactam in Critically Ill Patients
- Compare Ceftazidime-Avibactam + Metronidazole vs Meropenem for Hospitalized Adults With Complicated Intra-Abd Infections
- Comparing Oral Versus Parenteral Antimicrobial Therapy
- Comparison of Efficacy and Safety of Ceftazidime Avibactam Versus Extended Infusions of High Dose Meropenem in Patients of ACLF With Nosocomial Infections.
- CONTinuous Infusion Versus Intermittent Dosing of ceftaZidime/AVIbactam in Critically Ill Patients
- Different Administration Regimens of CAZ-AVI in Combination With ATM for the Treatment of CR-GNB

### Approved for (1)

- [Bacterial pneumonia](https://trialight.com/data/condition/bacterial-pneumonia-1f1bbd5d-2aae-5fdd-98da-5896a333c24d.md)

### In development for (9)

- [Acute pyelonephritis](https://trialight.com/data/condition/acute-pyelonephritis-83bd05de-bc8b-595e-ba5a-ab06709e6b77.md) Phase 3
- [Bacterial infectious disease](https://trialight.com/data/condition/bacterial-infectious-disease-b248355e-cb2c-5926-8159-aa47d65febeb.md) Phase 3
- [Gram-negative bacterial infections](https://trialight.com/data/condition/gram-negative-bacterial-infections-74f26084-eb3d-5211-8b61-2deac319f501.md) Phase 2
- Kidney failure Phase 1
- Meningitis Phase 2
- [Neutropenia](https://trialight.com/data/condition/neutropenia-30a0ef48-7a8d-552c-a177-b3165712f377.md) Phase 2
- [Pneumonia](https://trialight.com/data/condition/pneumonia-d2f12d4d-57c5-5c54-881e-1efe392849eb.md) Phase 3
- [Pyelonephritis](https://trialight.com/data/condition/pyelonephritis-3fc522f3-1bbe-5d31-9ffb-eacaa85f46c4.md) Phase 3
- [Urinary tract infection](https://trialight.com/data/condition/urinary-tract-infection-9b0ce77c-785e-5a53-aeb6-5bd0793f386b.md) Phase 2

### Other linked conditions (2)

- Acute respiratory distress syndrome
- Nosocomial infection

---

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