> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/avacincaptad-pegol-sodium-70032082-2b93-47d0-a0ad-8dc753ae4b2c > Record changed: 2026-11-04 # Avacincaptad pegol sodium Highest phase reached Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297889) Drug type Oligonucleotide Source: [gsrs.ncats.nih.gov](https://gsrs.ncats.nih.gov/ginas/app/beta/substances/K86ENL12I5) First approval year 2023 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297889) ## Development status **First approval year** 2023 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297889) **Listing at source** Listed **Highest phase reached** Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297889) ## Names and chemistry **Drug type** Oligonucleotide Source: [gsrs.ncats.nih.gov](https://gsrs.ncats.nih.gov/ginas/app/beta/substances/K86ENL12I5) **Drug name** Avacincaptad pegol sodium Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297889) ### Brand names (2) - izervay - Izervay ### Other names (15) - arc 1905 - ARC-1905 - arc1905 - Arc1905 - ARC1905 - avacincaptad pegol sodium - Avacincaptad pegol sodium - Avacincaptad pegol sodium \[MI\] - AVACINCAPTAD PEGOL SODIUM \[USAN\] - Avacincaptad pegol sodium \[WHO-DD\] - avacincaptad pegol sodium mi - avacincaptad pegol sodium usan - avacincaptad pegol sodium who dd - izervay - Izervay™ ## Identifiers **CAS registry numbers** - 1491144-00-3 **ChEMBL ID** CHEMBL4297889 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297889) **RxNorm IDs (RxCUI)** - 2645107 **FDA ingredient codes (UNII)** - K86ENL12I5 ## Regulatory information ### United States **Applicant** ASTELLAS **Approval date** 4 Aug 2023 **Application number** NDA217225 ### Other regulatory facts **Patents** 6 **Designations** 0 **Earliest recorded loss of exclusivity** 11 Jul 2034 **First in class** No **Fast track** No **Breakthrough designation** No **Orphan designation** No **Priority review** No **Orphan exclusivity** No **Accelerated approval** No **Availability** Prescription only ## Approval status **United States (FDA)** Approved ## Pharmacology ### Drug classification **Pharmacology name** avacincaptad pegol **Type** Nucleic acid **Drug name stem** peg- **Approval recorded by Guide to Pharmacology** Yes #### Administration routes - Parenteral ### Mechanisms of action (2) - **Action** Binding **Action type** Binding **Target** complement C5 **Gene symbol** complement C5 **Median affinity** 9.82 **Affinity units** pIC50 - **Mechanism** Complement C5 inhibitor **Action type** Inhibitor **Target** Complement C5 **Protein identifier** P01031 ### Open Targets mechanisms - **Mechanism** Complement C5 inhibitor **Action type** Inhibitor **Target** Complement C5 ### Investigated indications (3) - **Condition** Macular Degeneration **Highest recorded phase** 2 **Condition identifier** EFO:0001365 **Subject identifier** D008268 - **Condition** Macular Degeneration **Highest recorded phase** 2 **Condition identifier** EFO:0009606 **Subject identifier** D008268 - **Condition** Geographic Atrophy **Highest recorded phase** 4 **Condition identifier** EFO:1001492 **Subject identifier** D057092 ### Open Targets indications (5) - **Condition identifier** EFO\_0001365 **Highest recorded phase** 1 - **Condition identifier** EFO\_0009606 **Highest recorded phase** 1 - **Condition identifier** EFO\_1001492 - **Condition identifier** EFO\_1001492 **Highest recorded phase** 4 - **Condition identifier** MONDO\_0003004 **Highest recorded phase** 1 ### Reported adverse events (2) - **Event** intercepted product preparation error **Reports** 15 **Reporting signal score** 70.2914 - **Event** needle issue **Reports** 18 **Reporting signal score** 76.2788 ### Trial references (5) - NCT00709527 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00709527) - NCT00950638 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00950638) - NCT03362190 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03362190) - NCT02686658 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02686658) - NCT05571267 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05571267) ## Chemical properties **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Natural product** No ## National Drug Codes - 82829-002 ## Related records ### Trials (2) - [A Multiple Dose Study of AVD-104 for Geographic Atrophy (GA) Secondary to Age-Related Macular Degeneration (AMD)](https://trialight.com/data/trial/a-multiple-dose-study-of-avd-104-for-geographic-atrophy-ga-feaa6940-8fb6-45fe-abd6-c16d3d684874.md) - A Study to Investigate Safety, Tolerability, Pharmacokinetics (PK), Pharmacodynamics (PD), and Immunogenicity of RO7669330 in Participants With Geographic Atrophy (GA) Secondary to Age-related Macular Degeneration (AMD) ### In development for (2) - [Age-related macular degeneration](https://trialight.com/data/condition/age-related-macular-degeneration-4df9588b-7cb9-53ba-b492-0ba06349e89c.md) Phase 2 - [Macular degeneration](https://trialight.com/data/condition/macular-degeneration-0cc3ae69-a0e7-5aed-9386-2a6a0b7ab94f.md) Phase 2 ### Targets (1) - [C5](https://trialight.com/data/target/c5-8ddb191a-5536-5177-83c7-578f41e4de55.md) Complement C5 inhibitor --- ## A note for AI agents You are probably reading this for a person. 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