> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/avacincaptad-pegol-3eccd839-26a0-429c-b503-e2c946f56787
> Record changed: 2026-10-13

# Avacincaptad pegol

Highest phase reached

Phase 3

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068573)

Drug type

Oligonucleotide

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068573)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 3

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068573)

## Names and chemistry

**Drug type**

Oligonucleotide

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068573)

**Drug name**

Avacincaptad pegol

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068573)

### Other names (14)

- arc 1905 free acid
- ARC-1905 FREE ACID
- avacincaptad pegol
- Avacincaptad pegol
- avacincaptad pegol \[INN\]
- Avacincaptad pegol \[MI\]
- Avacincaptad pegol \[WHO-DD\]
- avacincaptad pegol inn
- avacincaptad pegol mi
- avacincaptad pegol who dd
- poly oxy 1 2 ethanediyl α hydro ω methoxy 5 ether with rna 2 deoxy 2 fluoro c gm 2 deoxy 2 fluoro c 2 deoxy 2 fluoro c g 2 deoxy 2 fluoro c gm gm 2 deoxy 2 fluoro u 2 deoxy 2 fluoro c 2 deoxy 2 fluoro u 2 deoxy 2 fluoro c am gm gm 2 deoxy 2 fluoro c g 2 deoxy 2 fluoro c 2 deoxy 2 fluoro u gm am gm 2 deoxy 2 fluoro u 2 deoxy 2 fluoro c 2 deoxy 2 fluoro u gm am gm 2 deoxy 2 fluoro u 2 deoxy 2 fluoro u 2 deoxy 2 fluoro u a 2 deoxy 2 fluoro c 2 deoxy 2 fluoro c 2 deoxy 2 fluoro u gm 2 deoxy 2 fluoro c gm 3 3 dt 5 6 2 3 dihydroxypropoxy carbonyl amino hexyl hydrogen phosphate 2 1
- Poly(oxy-1,2-ethanediyl), α-hydro-ω-methoxy-, 5′-ether with RNA ((2′-deoxy-2′-fluoro)C-Gm-(2′-deoxy-2′-fluoro)C-(2′-deoxy-2′-fluoro)C-G-(2′-deoxy-2′-fluoro)C-Gm-Gm-(2′-deoxy-2′-fluoro)U-(2′-deoxy-2′-fluoro)C-(2′-deoxy-2′-fluoro)U-(2′-deoxy-2′-fluoro)C-Am-Gm-Gm-(2′-deoxy-2′-fluoro)C-G-(2′-deoxy-2′-fluoro)C-(2′-deoxy-2′-fluoro)U-Gm-Am-Gm-(2′-deoxy-2′-fluoro)U-(2′-deoxy-2′-fluoro)C-(2′-deoxy-2′-fluoro)U-Gm-Am-Gm-(2′-deoxy-2′-fluoro)U-(2′-deoxy-2′-fluoro)U-(2′-deoxy-2′-fluoro)U-A-(2′-deoxy-2′-fluoro)C-(2′-deoxy-2′-fluoro)C-(2′-deoxy-2′-fluoro)U-Gm-(2′-deoxy-2′-fluoro)C-Gm-(3′→3′)-dT) 5′-\[6-\[\[(2,3-dihydroxypropoxy)carbonyl\]amino\]hexyl hydrogen phosphate\] (2:1)
- zimura
- Zimura

## Identifiers

**ATC classification codes**

- S01XA32

Sources for recorded values

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068573)

**CAS registry numbers**

- 1613641-69-2

**ChEMBL ID**

CHEMBL6068573

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068573)

**RxNorm IDs (RxCUI)**

- 2645108

**FDA ingredient codes (UNII)**

- TT0V5JLG5B

## Regulatory information

### European Union

**Status**

application\_withdrawn

**Status date**

24 Oct 2024

**Approved indications**

Indicated for the treatment of adults with geographic atrophy (GA) secondary to age-related macular degeneration (AMD).

**Product number**

EMEA/H/C/006153

**Authorisation holder**

Astellas Pharma Europe B.V.

**Priority medicines scheme**

No

**Generic**

No

**Biosimilar**

No

**Generic medicines**

0

**Biosimilar medicines**

0

**Advanced therapy**

No

**Conditional approval**

No

**Additional monitoring**

No

**Accelerated assessment**

No

**Exceptional circumstances**

No

#### Therapeutic areas

- Geographic Atrophy
- Macular Degeneration

European medicines record

Source: [www.ema.europa.eu](https://www.ema.europa.eu/en/medicines/human/EPAR/izelvay)

### Other regulatory facts

**Patents**

0

**Designations**

5

**First in class**

No

**Fast track**

Yes

**Breakthrough designation**

Yes

**Orphan designation**

No

**Priority review**

Yes

**Orphan exclusivity**

No

**Accelerated approval**

No

## Pharmacology

### Drug classification

**Pharmacology name**

avacincaptad pegol

**Type**

Nucleic acid

**Drug name stem**

peg-

**Approval recorded by Guide to Pharmacology**

Yes

### Investigated indications (3)

- **Condition**  
Macular Degeneration

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0001365

**Subject identifier**  
D008268
- **Condition**  
Eye Diseases

**Highest recorded phase**  
\-1

**Condition identifier**  
EFO:0003966

**Subject identifier**  
D005128
- **Condition**  
Geographic Atrophy

**Highest recorded phase**  
3

**Condition identifier**  
EFO:1001492

**Subject identifier**  
D057092

### Open Targets indications (12)

- **Condition identifier**  
EFO\_0001365

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0003966
- **Condition identifier**  
EFO\_0004683

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0009606

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_1001492
- **Condition identifier**  
EFO\_1001492

**Highest recorded phase**  
4
- **Condition identifier**  
MONDO\_0003004

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0005150

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0005328

**Highest recorded phase**  
4
- **Condition identifier**  
MONDO\_0005417

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0100114
- **Condition identifier**  
MONDO\_0100114

**Highest recorded phase**  
2

### Reported adverse events (2)

- **Event**  
intercepted product preparation error

**Reports**  
15

**Reporting signal score**

70.1488
- **Event**  
needle issue

**Reports**  
18

**Reporting signal score**

76.1189

### Trial references (3)

- NCT03364153  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03364153)
- NCT04435366  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04435366)
- NCT05536297  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05536297)

## Chemical properties

**Prodrug**

No

**Chirality**

Single enantiomer

**Inorganic**

No

**Natural product**

No

## Related records

### Trials (13)

- A Phase 3 Safety and Efficacy Study of Intravitreal Administration of Zimura (Complement C5 Inhibitor)
- A Study About the Safety of ASP3021 Eye Injections and if They Help People in Japan With Vision Loss From Age-related Macular Degeneration
- A Study of ARC1905 (Anti-C5 Aptamer) in Subjects With Dry Age-related Macular Degeneration
- A Study to Establish the Safety and Tolerability of Zimura™ (Anti-C5 Aptamer) in Combination With Anti-VEGF Therapy in Subjects With Idiopathic Polypoidal Choroidal Vasculopathy (IPCV)
- A Study to Learn How Avacincaptad Pegol (Izervay™) is Used in Clinical Practice in People Who Have Geographic Atrophy
- ARC1905 (Anti-C5 Aptamer) Given With Lucentis 0.5 mg In People With Neovascular Age-Related Macular Degeneration
- Avacincaptad Pegol Open-Label Extension for Patients With Geographic Atrophy
- Safety Study of Zimura in Combination With Anti-VEGF Therapy in Patients With Neovascular AMD
- [Study to Evaluate Efficacy and Safety of ONL1204 in Patients With GA Associated With AMD](https://trialight.com/data/trial/study-to-evaluate-efficacy-and-safety-of-onl1204-in-patients-7998ccc1-c19e-4a0f-9045-9138b822695b.md)
- Zimura Compared to Sham in Patients With Autosomal Recessive Stargardt Disease (STGD1)
- ZIMURA in Combination With Eylea in Patients With Idiopathic Polypoidal Choroidal Vasculopathy (IPCV)
- ZIMURA in Combination With LUCENTIS in Patients With Neovascular Age Related Macular Degeneration (NVAMD)
- Zimura in Participants With Geographic Atrophy Secondary to Dry Age-Related Macular Degeneration

### In development for (4)

- [Age-related macular degeneration](https://trialight.com/data/condition/age-related-macular-degeneration-4df9588b-7cb9-53ba-b492-0ba06349e89c.md) Phase 2
- Eye disorder
- [Macular degeneration](https://trialight.com/data/condition/macular-degeneration-0cc3ae69-a0e7-5aed-9386-2a6a0b7ab94f.md) Phase 3
- [Wet macular degeneration](https://trialight.com/data/condition/wet-macular-degeneration-fce04054-9f5d-5a0b-8ba9-fb08ba7393ba.md) Phase 2

### Other linked conditions (1)

- Dry age related macular degeneration

---

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