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Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/autologous-cultured-chondrocytes-43258f87-47bc-41e2-b6a7-b6085ebf101f > Record changed: 2026-10-13 # Autologous cultured chondrocytes Highest phase reached Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5315092) Drug type Unknown First approval year 2009 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5315092) ## Development status **First approval year** 2009 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5315092) **Listing at source** Listed **Highest phase reached** Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5315092) ## Names and chemistry **Drug type** Unknown **Drug name** Autologous cultured chondrocytes Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5315092) ### Brand names (2) - maci - Maci ### Other names (15) - autologous cultured chondrocytes - Autologous cultured chondrocytes - carticel - Carticel - characterised viable autologous cartilage cells expanded ex vivo expressing specific marker proteins - CHARACTERISED VIABLE AUTOLOGOUS CARTILAGE CELLS EXPANDED EX VIVO EXPRESSING SPECIFIC MARKER PROTEINS - CHARACTERISED VIABLE AUTOLOGOUS CARTILAGE CELLS EXPANDED EX VIVO EXPRESSING SPECIFIC MARKER PROTEINS \[EMA EPAR\] - characterised viable autologous cartilage cells expanded ex vivo expressing specific marker proteins ema epar - chondrocelect - CHONDROCELECT - maci - Maci - MACI - matrix applied characterised autologous cultured chondrocytes - Matrix-applied characterised autologous cultured chondrocytes ## Identifiers **ChEMBL ID** CHEMBL5315092 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5315092) **FDA ingredient codes (UNII)** - D5P3K3V822 ## Regulatory information ### Other regulatory facts **First in class** No **Orphan designation** No ## Pharmacology ### Investigated indications (2) - **Condition** Fractures, Cartilage **Highest recorded phase** 4 **Subject identifier** D050724 - **Condition** Cartilage Diseases **Highest recorded phase** 4 **Condition identifier** EFO:0005802 **Subject identifier** D002357 ### Open Targets indications (6) - **Condition identifier** EFO\_0005802 - **Condition identifier** EFO\_0005802 **Highest recorded phase** 4 - **Condition identifier** MONDO\_0003816 - **Condition identifier** MONDO\_0003816 **Highest recorded phase** 4 - **Condition identifier** MONDO\_0004355 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0005178 **Highest recorded phase** 1 ### Reported adverse events (30) - **Event** adhesion **Reports** 6 **Reporting signal score** 25.8467 - **Event** arthralgia **Reports** 42 **Reporting signal score** 40.6385 - **Event** arthrofibrosis **Reports** 12 **Reporting signal score** 87.2885 - **Event** arthropathy **Reports** 13 **Reporting signal score** 19.6992 - **Event** chondromalacia **Reports** 25 **Reporting signal score** 174.796 - **Event** chondropathy **Reports** 17 **Reporting signal score** 82.9315 - **Event** chondroplasty **Reports** 5 **Reporting signal score** 35.2955 - **Event** exostosis **Reports** 37 **Reporting signal score** 165.489 - **Event** failure of implant **Reports** 32 **Reporting signal score** 238.702 - **Event** graft complication **Reports** 55 **Reporting signal score** 395.013 - **Event** graft delamination **Reports** 21 **Reporting signal score** 178.842 - **Event** graft overgrowth **Reports** 15 **Reporting signal score** 126.438 - **Event** hypertrophy **Reports** 15 **Reporting signal score** 88.8862 - **Event** inadequate osteointegration **Reports** 4 **Reporting signal score** 30.4916 - **Event** joint adhesion **Reports** 12 **Reporting signal score** 91.6076 - **Event** joint effusion **Reports** 10 **Reporting signal score** 30.2284 - **Event** joint lock **Reports** 8 **Reporting signal score** 32.61 - **Event** joint swelling **Reports** 17 **Reporting signal score** 19.6525 - **Event** localised osteoarthritis **Reports** 10 **Reporting signal score** 65.8771 - **Event** loose body in joint **Reports** 22 **Reporting signal score** 148.835 - **Event** meniscus lesion **Reports** 11 **Reporting signal score** 50.1617 - **Event** osteoarthritis **Reports** 11 **Reporting signal score** 18.3211 - **Event** patellofemoral pain syndrome **Reports** 11 **Reporting signal score** 60.6097 - **Event** post procedural complication **Reports** 15 **Reporting signal score** 40.0684 - **Event** post procedural pain **Reports** 7 **Reporting signal score** 43.2063 And 5 more, listed on the interactive page. ## Dosing ### Conditions of use (3) - Implant should be cut to the size and shape of the defect - Single-use implant, multiple implants may be used if more than one defect - Use during surgical implantation only ## Chemical properties **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Natural product** No ## Related records ### Trials (73) - A Clinical Trial Testing Root Coverage With Acellular Dermal Matrix in Thin and Thick Gingival Biotypes - A Phase 3 Study to Evaluate the Long-Term Safety of ThermoProfen™ in Patients With Mild to Moderate Pain Associated With Osteoarthritis of the Knee. - A Prospective Clinical Study to Evaluate the Effectiveness and Safety of Xcell Amnio MatrixTM (XAM) in the Management of Chronic Non-healing DFUs - A Safety and Efficacy Study of R21 +/- ChAd63/MVA ME-TRAP - A Study of Different Injectable Formulations of LY3375880 in Healthy Participants - A Study of MACI in Patients Aged 10 to 17 Years With Symptomatic Chondral or Osteochondral Defects of the Knee - A Study of MACI in Patients Aged 17 to 65 Years With Symptomatic Chondral or Osteochondral Defects of the Ankle - A Study of REcycled CartiLage Auto/Allo IMplantation to Treat and Repair Focal Hip Cartilage Defects - A Study to Assess the Safety and Immunogenicity of the Malaria Vaccine, R21, Administered With and Without Matrix-M1 - A Study to Assess the Safety and Immunogenicity of the Malaria Vaccine, R21, With Matrix-M1 Adjuvant - An Observational, Prospective Study of Patients With Chondral and/or Osteochondral Defects of the Knee Treated With NAMIC - Assessment of Safety, Immunogenicity and Efficacy of R21/Matrix-M1 Malaria Vaccine in Healthy WOCBP in Mali - Autologous Cell-derived Tissue Engineered Cartilage for Repairing Articular Cartilage Lesions - Biologicals in Management of Intra-Bony Defects - Blood-saving Effect of Combined Intravenous Tranexamic Acid With Topical Floseal® Application Total Hip Arthroplasty - Bone Defects Reconstruction After Dentigerous Cyst Enucleation With Autogenous Demineralized Dentin Matrix- ADDM and Advanced Platelet-Rich Fibrin- A-PRF. - Cellular Therapy for In Utero Repair of Myelomeningocele - The CuRe Trial - Clinical and Radiographic Evaluation of Three Biomimetic Materials in Pulp Therapy of Immature Young Permanent Teeth "A Randomized Controlled Clinical Trial" - Clinical Outcomes Associated With the Use of ViviGen® for the Treatment of Lumbar Degenerative Disc Disease - Clinical, Radiographic and Volumetric Evaluation of the Entire Papilla Preservation Technique With and Without Connective Tissue Graft in the Treatment of Periodontal Intraosseous Defects. ### Approved for (1) - Chondromalacia ### In development for (1) - Childhood leukemia Phase 3 ### Other linked conditions (1) - Articular cartilage disorder --- ## A note for AI agents You are probably reading this for a person. 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