> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/autogene-cevumeran-eb4276fe-4301-43ae-889f-3f338e7e2485
> Record changed: 2026-11-04

# Autogene cevumeran

Highest phase reached

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4650376)

Drug type

Oligonucleotide

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4650376)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4650376)

## Names and chemistry

**Drug type**

Oligonucleotide

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4650376)

**Drug name**

Autogene cevumeran

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4650376)

### Other names (25)

- a 5 capped single stranded messenger rna mrna construct for the expression of patient specific tumour neoantigens comprising a 5 cap a 5 untranslated region derived from human alpha globin mrna an optimised kozak sequence sequences encoding a secretory signal peptide sec 2 0 transmembrane and cytoplasmic domains of a major histocompatibility complex mhc class i molecule mitd a 3 untranslated region fi and a poly a tail sequences encoding patient specific antigens are inserted between the secretory signal peptide and the transmembrane cytoplasmic encoding domains
- A 5'-capped single-stranded messenger RNA (mRNA) construct for the expression of patient-specific tumour neoantigens comprising a 5'-cap, a 5'-untranslated region derived from human alpha-globin mRNA, an optimised Kozak sequence, sequences encoding a secretory signal peptide (sec 2.0), transmembrane and cytoplasmic domains of a major histocompatibility complex (MHC) Class I molecule (MITD), a 3'-untranslated region (FI) and a poly(A)-tail; sequences encoding patient specific antigens are inserted between the secretory signal peptide and the transmembrane/cytoplasmic encoding domains
- autogene cevumeran
- Autogene cevumeran
- Autogene Cevumeran
- autogene cevumeran \[INN\]
- AUTOGENE CEVUMERAN \[USAN\]
- Autogene cevumeran \[WHO-DD\]
- autogene cevumeran inn
- autogene cevumeran usan
- autogene cevumeran who dd
- bnt 122
- BNT-122
- bnt122
- BNT122
- rg 6180
- RG 6180
- RG-6180
- RNA (recombinant 5′-\[1,2-\[m7Gm-(5′→5′)-p-\[P(R)\]-sp-p-G\]\]-capped 5′-UTR (human α-globin RNA-Kozak)/secretory signal peptide sec2.0-specifying/patient-specific tumor neoantigen-specifying insertion site/major histocompatibility complex class I transmembrane and cytoplasmic domains-specifying/3′-UTR (AES mRNA-mitochondrial 12S rRNA)-containing poly(A)-tailed messenger RO7198457 constant region), inner salt
- rna recombinant 5 1 2 m7gm 5 5 p p r sp p g capped 5 utr human α globin rna kozak secretory signal peptide sec2 0 specifying patient specific tumor neoantigen specifying insertion site major histocompatibility complex class i transmembrane and cytoplasmic domains specifying 3 utr aes mrna mitochondrial 12s rrna containing poly a tailed messenger ro7198457 constant region inner salt
- ro 7198457
- RO-7198457
- ro7198457
- Ro7198457
- RO7198457

## Identifiers

**CAS registry numbers**

- 2365453-34-3

**ChEMBL ID**

CHEMBL4650376

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4650376)

**FDA ingredient codes (UNII)**

- L8HDH9IB06

## Regulatory information

### Other regulatory facts

**First in class**

No

**Orphan designation**

No

## Pharmacology

### Drug classification

**Drug name stem**

\-meran

### Investigated indications (6)

- **Condition**  
Neoplasms

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0000616

**Subject identifier**  
D009369
- **Condition**  
Melanoma

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000756

**Subject identifier**  
D008545
- **Condition**  
Pancreatic Neoplasms

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0002618

**Subject identifier**  
D010190
- **Condition**  
Carcinoma, Non-Small-Cell Lung

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0003060

**Subject identifier**  
D002289
- **Condition**  
Head and Neck Neoplasms

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0006859

**Subject identifier**  
D006258
- **Condition**  
Carcinoma, Pancreatic Ductal

**Highest recorded phase**  
2

**Condition identifier**  
MONDO:0005184

**Subject identifier**  
D021441

### Open Targets indications (11)

- **Condition identifier**  
EFO\_0000616
- **Condition identifier**  
EFO\_0000756

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0002617

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0003060

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0005070
- **Condition identifier**  
MONDO\_0005105

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0005184

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0005191

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0005192

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0005233

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0005575

**Highest recorded phase**  
2

### Reported adverse events

- **Event**  
electrocardiogram t wave abnormal

**Reports**  
1

**Reporting signal score**

7.3771

### Trial references (5)

- NCT03289962  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03289962)
- NCT03815058  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03815058)
- NCT04267237  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04267237)
- NCT04161755  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04161755)
- NCT05968326  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05968326)

## Chemical properties

**Prodrug**

No

**Chirality**

Single enantiomer

**Inorganic**

No

**Natural product**

No

### Sequences

- **Component**  
Sequence

**Type**  
Nucleic Acid

**Sequence**  
ggggcgaacuaguauucuucugguccccacagacucagagagaacccgccaccaugagagugauggcccccagaacccugauccugcugcugucuggcgcccuggcccugacagagacaugggccggaagcnaucgugggaauuguggcaggacuggcagugcuggccgugguggugaucggagccgugguggcuaccgugaugugcagacggaaguccagcggaggcaagggcggcagcuacagccaggccgccagcucugauagcgcccagggcagcgacgugucacugacagccuaguaacucgagcugguacugcaugcacgcaaugcuagcugccccuuucccguccuggguaccccgagucucccccgaccucgggucccagguaugcucccaccuccaccugccccacucaccaccucugcuaguuccagacaccucccaagcacgcagcaaugcagcucaaaacgcuuagccuagccacacccccacgggaaacagcagugauuaaccuuuagcaauaaacgaaaguuuaacuaagcuauacuaaccccaggguuggucaauuucgugccagccacaccgagaccugguccagagucgcuagccgcgucgcuaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa

## Related records

### Trials (7)

- A Phase II Clinical Trial Comparing the Efficacy of RO7198457 Versus Watchful Waiting in Patients With ctDNA-positive, Resected Stage II (High Risk) and Stage III Colorectal Cancer
- A Study of Autogene Cevumeran (RO7198457) as a Single Agent and in Combination With Atezolizumab in Participants With Locally Advanced or Metastatic Tumors
- [A Study of the Efficacy and Safety of Adjuvant Autogene Cevumeran Plus Atezolizumab and mFOLFIRINOX Versus mFOLFIRINOX Alone in Participants With Resected PDAC](https://trialight.com/data/trial/a-study-of-the-efficacy-and-safety-of-adjuvant-autogene-0fd31dc5-b562-4742-9912-7802b13d3e70.md)
- A Study of the Efficacy and Safety of RO7198457 in Combination With Atezolizumab Versus Atezolizumab Alone Following Adjuvant Platinum-Doublet Chemotherapy in Participants Who Are ctDNA Positive After Surgical Resection of Stage II-III Non-Small Cell Lung Cancer
- A Study to Evaluate the Efficacy and Safety of Autogene Cevumeran (RO7198457) in Combination With Pembrolizumab Versus Pembrolizumab Alone in Participants With Previously Untreated Advanced Melanoma.
- A Study to Evaluate the Efficacy and Safety of Autogene Cevumeran With Nivolumab Versus Nivolumab Alone in Participants With High-risk Muscle-invasive Urothelial Carcinoma (MIUC)
- Study of Personalized Tumor Vaccines (PCVs) and a PD-L1 Blocker in Patients With Pancreatic Cancer That Can be Treated With Surgery

### In development for (8)

- [Colorectal cancer](https://trialight.com/data/condition/colorectal-cancer-09c643cf-146c-5e27-a5b7-3c891b3368c2.md) Phase 2
- Exocrine pancreatic carcinoma Phase 2
- [Head and neck cancer](https://trialight.com/data/condition/head-and-neck-cancer-3a2645b9-a3db-5103-b6f8-5d2ec40c5339.md) Phase 1
- [Melanoma](https://trialight.com/data/condition/melanoma-457e9de6-dcd9-56fb-be48-0290fb4386ef.md) Phase 2
- [Metastatic melanoma](https://trialight.com/data/condition/metastatic-melanoma-a7d9cd5e-6b12-5442-ba47-7839b5fda64e.md) Phase 2
- [Neoplasm](https://trialight.com/data/condition/neoplasm-2a973797-359b-5982-907e-98f9b7c1a284.md) Phase 1
- [Non-small cell lung carcinoma](https://trialight.com/data/condition/non-small-cell-lung-carcinoma-a86c1d60-523f-5ea7-a5e1-39ed4a2296f8.md) Phase 2
- [Pancreatic ductal adenocarcinoma](https://trialight.com/data/condition/pancreatic-ductal-adenocarcinoma-77c1c5a8-638b-51d0-b18e-2c881b8902e5.md) Phase 2

---

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