> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/atuliflapon-850ef0c1-21fa-44ee-bad0-082cfb01dd83
> Record changed: 2026-10-13

# Atuliflapon

Highest phase reached

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4802195)

Drug type

Small molecule

Source: [gsrs.ncats.nih.gov](https://gsrs.ncats.nih.gov/ginas/app/beta/substances/NV6352Y6TV)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4802195)

## Names and chemistry

**Drug type**

Small molecule

Source: [gsrs.ncats.nih.gov](https://gsrs.ncats.nih.gov/ginas/app/beta/substances/NV6352Y6TV)

**Drug name**

Atuliflapon

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4802195)

**Structure (SMILES)**

These details could not be displayed.

### Other names (14)

- atuliflapon
- Atuliflapon
- atuliflapon \[INN\]
- Atuliflapon \[WHO-DD\]
- atuliflapon inn
- atuliflapon who dd
- azd 5718
- Azd 5718
- AZD-5718
- azd5718
- Azd5718
- AZD5718
- AZD5718 IR tablet
- AZD5718 oral suspension

## Identifiers

**CAS registry numbers**

- 2041075-86-7

**ChEMBL ID**

CHEMBL4802195

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4802195)

**InChIKey**

ROTWSDMXHVGAHZ-QZTJIDSGSA-N

Source: [gsrs.ncats.nih.gov](https://gsrs.ncats.nih.gov/ginas/app/beta/substances/NV6352Y6TV)

**PubChem compound IDs**

- 122678117

**FDA ingredient codes (UNII)**

- NV6352Y6TV

## Regulatory information

### Other regulatory facts

**First in class**

No

**Orphan designation**

No

## Pharmacology

### Drug classification

**Pharmacology name**

AZD5718

**Type**

Synthetic organic

**Drug name stem**

\-flapon

### Mechanisms of action

- **Action**  
Inhibition

**Action type**  
Inhibitor

**Target**  
5-LOX activating protein

**Gene symbol**  
5-LOX activating protein

**Median affinity**

8.2

**Affinity units**  
pIC50

### Investigated indications (4)

- **Condition**  
Cardiovascular Diseases

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0000319

**Subject identifier**  
D002318
- **Condition**  
Coronary Disease

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0001645

**Subject identifier**  
D003327
- **Condition**  
Renal Insufficiency, Chronic

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0003884

**Subject identifier**  
D051436
- **Condition**  
Acute Coronary Syndrome

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0005672

**Subject identifier**  
D054058

### Open Targets indications (11)

- **Condition identifier**  
EFO\_0000319

**Highest recorded phase**  
1
- **Condition identifier**  
EFO\_0001645

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0003884

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0005672

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0008585

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0008586

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0004979

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0005010

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0005016

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0005068

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0005542

**Highest recorded phase**  
2

### Trial references (12)

- NCT02632526  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02632526)
- NCT03948451  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03948451)
- NCT04492709  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04492709)
- NCT02963116  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02963116)
- NCT03317002  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03317002)
- NCT03400488  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03400488)
- NCT03420092  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03420092)
- NCT04087187  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04087187)
- NCT04210388  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04210388)
- NCT04492722  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04492722)
- NCT04734275  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04734275)
- NCT04601467  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04601467)

## Chemical properties

**Calculated partition coefficient (XLogP)**

2.5

**Prodrug**

No

**Chirality**

Single enantiomer

**Inorganic**

No

**Heavy atoms**

33

**Monoisotopic mass**

446.20663871

**Natural product**

No

## Evidence counts

**Recorded assays**

111

**Active assays**

6

### Active assay types

- Confirmatory

## Related records

### Trials (12)

- A Study to Assess the Amount of Drug Levels in Blood and Safety of AZD5718 Formulations in Healthy Volunteers
- A Study to Assess the Bioavailability of Different Formulations of AZD5718 and the Food Effect on the Selected Formulation of AZD5718 in Healthy Volunteers
- A Study to Assess the Effect of Multiple Doses of AZD5718 on Pharmacokinetics of Oral Midazolam in Healthy Subjects
- A Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of AZD5718 After Single and Multiple Ascending Dose Administration to Healthy Japanese Men
- A Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of AZD5718 After Single and Multiple Ascending Dose Administration to Healthy Male Subjects
- A Study to Estimate the Effect of AZD5718 on the Pharmacokinetics (What Does the Body Does to the Drug) of Rosuvastatin to Measure the Relative Bioavailability (the Extent to Which a Drug or Other Substance Becomes Available to the Body) of AZD5718 Oral Suspension vs AZD5718 Immediate Release Tablet
- A Study to Evaluate the Safety and Efficacy of AZD5718 in Participants With Proteinuric Chronic Kidney Disease
- AZD5718 Phase IIa Study to Evaluate Efficacy, Safety and Tolerability of Oral AZD5718 in Patients With Coronary Artery Disease (CAD).
- PASSIvation of Vulnerable Plaque With AZD5718 in AcuTe Coronary syndromE
- Study Evaluating the Pharmacokinetic and Mass Balance of Single Dose \[14C\] AZD5718 in Volunteers
- Study to Assess Relative Bioavailability and Safety of AZD5718 in Healthy Volunteers
- [Study to Assess the Efficacy and Safety of Atuliflapon in Moderate-to-Severe Uncontrolled Asthma](https://trialight.com/data/trial/study-to-assess-the-efficacy-and-safety-of-atuliflapon-in-d88ae65a-136b-48ca-a69e-6e1649bfff13.md)

### In development for (5)

- [Acute coronary syndrome](https://trialight.com/data/condition/acute-coronary-syndrome-3d7c2c1f-86ca-5a25-913a-6f9a7e95f989.md) Phase 2
- [Asthma](https://trialight.com/data/condition/asthma-247437fb-0e60-5885-8a3a-ce40099cea88.md) Phase 2
- [Cardiovascular disorder](https://trialight.com/data/condition/cardiovascular-disorder-362e433e-88a4-575f-90af-50fe7239dec0.md) Phase 1
- [Chronic kidney disease](https://trialight.com/data/condition/chronic-kidney-disease-dc1fecbb-338b-5bbc-8d68-08e49db49918.md) Phase 2
- [Coronary artery disorder](https://trialight.com/data/condition/coronary-artery-disorder-6f736849-d477-587a-b3fa-b0621d573407.md) Phase 2

---

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