> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/atogepant-06c1e020-1758-4b06-8f37-1c53649d9a0b > Record changed: 2026-10-13 # Atogepant Highest phase reached Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3991065) Drug type Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3991065) First approval year 2021 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3991065) ## Development status **First approval year** 2021 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3991065) **Listing at source** Listed **Highest phase reached** Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3991065) ## Names and chemistry **Drug type** Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3991065) **Drug name** Atogepant Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3991065) **Molecular weight** 603.52 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3991065) **Structure (SMILES)** C\[C@@H\]1\[C@H\](c2c(F)ccc(F)c2F)C\[C@H\](NC(=O)c2cnc3c(c2)C\[C@@\]2(C3)C(=O)Nc3ncccc32)C(=O)N1CC(F)(F)F Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3991065) ### Brand names (4) - aquipta - Aquipta - qulipta - Qulipta ### Other names (18) - agn 241689 - AGN-241689 - atogepant - Atogepant - atogepant \[INN\] - Atogepant \[MI\] - ATOGEPANT \[ORANGE BOOK\] - ATOGEPANT \[USAN\] - Atogepant \[WHO-DD\] - Atogepant 30 mg - Atogepant 60 mg - atogepant inn - atogepant mi - atogepant orange book - atogepant usan - atogepant who dd - mk 8031 - MK-8031 ## Identifiers **ATC classification codes** - N02CD07 Sources for recorded values Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3991065) **CAS registry numbers** - 1374248-81-3 **ChEMBL ID** CHEMBL3991065 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3991065) **InChIKey** QIVUCLWGARAQIO-OLIXTKCUSA-N Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3991065) **PubChem compound IDs** - 72163100 **RxNorm IDs (RxCUI)** - 2571813 **FDA ingredient codes (UNII)** - 7CRV8RR151 ## Regulatory information ### United States **Applicant** ABBVIE **Approval date** 28 Sept 2021 **Application number** NDA215206 ### European Union **Status** Authorised **Status date** 11 Aug 2023 **Authorisation date** 11 Aug 2023 **Approved indications** Aquipta is indicated for: - acute treatment of migraine with or without aura in adults - prophylaxis of migraine in adults who have at least 4 migraine days per month. **Product number** EMEA/H/C/005871 **Authorisation holder** AbbVie Deutschland GmbH & Co. KG **Priority medicines scheme** No **Generic** No **Biosimilar** No **Generic medicines** 0 **Biosimilar medicines** 0 **Advanced therapy** No **Conditional approval** No **Additional monitoring** Yes **Accelerated assessment** No **Exceptional circumstances** No #### Therapeutic areas - Migraine Disorders European medicines record Source: [www.ema.europa.eu](https://www.ema.europa.eu/en/medicines/human/EPAR/aquipta) ### Other regulatory facts **Patents** 8 **Designations** 0 **Earliest recorded loss of exclusivity** 27 Feb 2043 **First in class** No **Fast track** No **Breakthrough designation** No **Orphan designation** No **Priority review** No **Orphan exclusivity** No **Accelerated approval** No **Availability** Prescription only ## Pharmacology ### Drug classification **Pharmacology name** atogepant **Type** Synthetic organic **Drug name stem** \-gepant **Approval recorded by Guide to Pharmacology** Yes #### Administration routes - Oral ### Mechanisms of action (3) - **Action** Antagonist **Action type** Antagonist **Target** CGRP receptor **Gene symbol** RAMP1 **Protein identifier** O60894 **Median affinity** 10.82 **Affinity units** pKi - **Action** Antagonist **Action type** Antagonist **Target** CGRP receptor **Gene symbol** CALCRL **Protein identifier** Q16602 **Median affinity** 10.82 **Affinity units** pKi - **Mechanism** Calcitonin gene-related peptide type 1 receptor antagonist **Action type** Antagonist **Target** Calcitonin gene-related peptide type 1 receptor **Protein identifier** Q16602 ### Open Targets mechanisms - **Mechanism** Calcitonin gene-related peptide type 1 receptor antagonist **Action type** Antagonist **Target** Calcitonin gene-related peptide type 1 receptor ### Investigated indications - **Condition** Migraine Disorders **Highest recorded phase** 4 **Condition identifier** MONDO:0005277 **Subject identifier** D008881 ### Open Targets indications (3) - **Condition identifier** EFO\_0008008 - **Condition identifier** MONDO\_0005277 - **Condition identifier** MONDO\_0005277 **Highest recorded phase** 4 ### Trial references (18) - NCT02848326 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02848326) - NCT03700320 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03700320) - NCT03777059 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03777059) - NCT03855137 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03855137) - NCT03939312 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03939312) - NCT04437433 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04437433) - NCT04686136 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04686136) - NCT04740827 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04740827) - NCT04818515 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04818515) - NCT04829747 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04829747) - NCT04961671 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04961671) - NCT05216263 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05216263) - NCT05264129 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05264129) - NCT05707949 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05707949) - NCT05711394 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05711394) - NCT05748483 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05748483) - NCT05861427 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05861427) - NCT06241313 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06241313) ## Dosing **Dose** 10 mg, 30 mg, or 60 mg **Route** Oral **How often** Once daily ## Chemical properties **Hydrogen bond acceptors** 5 **Hydrogen bond donors** 2 **Polar surface area** 104.29 **Calculated partition coefficient (ALogP)** 3.95 **Calculated partition coefficient (XLogP)** 3.4 **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Rule-of-five violations** 1 **Rotatable bonds** 4 **Heavy atoms** 43 **Molecular formula** C29H23F6N5O3 **Monoisotopic mass** 603.17050859 **Natural product** No ## National Drug Codes - 0074-7094 - 0074-7095 - 0074-7096 ## Evidence counts **Recorded assays** 6 **Active assays** 4 ### Active assay types - Confirmatory ## Related records ### Trials (28) - 12-Week Placebo-controlled Study of Atogepant for the Preventive Treatment of Migraine in Participants With Episodic Migraine - A Long-Term Safety and Tolerability Extension Study Evaluating Atogepant for the Prevention of Chronic or Episodic Migraine - A Study Evaluating Oral Atogepant for the Prevention of Migraine in Japanese Participants With Chronic or Episodic Migraine - A Study of Oral Atogepant Tablets to Assess Adverse Events and Change in Disease Activity To Prevent Migraine in Participants Aged 12 to 17 Years - A Study to Assess the Adverse Events and Change in Disease Activity of Oral Atogepant Tablets in Pediatric Participants (6-17 Years of Age) With Episodic Migraine - Atogepant for Prophylaxis of Migraine in Participants Who Failed Previous Oral Prophylactic Treatments. - Atogepant in Real Life in Italy (GIANT) - Comparative Effectiveness of Migraine Preventive Medications: The APT Comparison Study - Comparative Study of Oral Atogepant Versus Oral Topiramate to Assess Adverse Events in Adult Participants With Migraine - Comparing Migraine Preventive Therapies vs. Anti-CGRP Therapies for Tinnitus in Patients With Migraine (COMPACT-PM) - Efficacy, Safety, and Tolerability of Atogepant for the Prevention of Chronic Migraine - Efficacy, Safety, and Tolerability of Multiple Dosing Regimens of Oral Atogepant (AGN-241689) in Episodic Migraine Prevention - Extension Study to Evaluate the Long-Term Safety and Tolerability of Oral Atogepant for the Prevention of Migraine in Participants With Episodic Migraine - Italian Real-life obServational Study on the effecTiveness, sAfety and Tolerability of Atogepant in Migraine Patients - Long-term Atogepant in Real-world Practice - Long-term Extension Study to Assess Adverse Events of Oral Atogepant Tablets in Pediatric Participants (6 to 17 Years of Age) With Migraine - Migraine Medication Effects on Urinary Symptoms - Neurophysiological and Biomolecular Effects of Atogepant in Episodic Migraine - Post-Marketing Study to Assess the Safety and Effectiveness of Oral Atogepant in Korean Adult Participants for the Prevention of Chronic or Episodic Migraine - Study of Oral Atogepant Tablets to Assess Change in Disease Activity in Adult Japanese Participants With Episodic Migraine ### Approved for (1) - [Migraine disorder](https://trialight.com/data/condition/migraine-disorder-0a28e77d-6415-5582-980f-2d0721f95f76.md) ### Targets (1) - [CALCRL](https://trialight.com/data/target/calcrl-ab682234-2bfa-51bd-a9eb-e0d3e9a4ee16.md) Calcitonin gene-related peptide type 1 receptor antagonist --- ## A note for AI agents You are probably reading this for a person. 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