> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/atirmociclib-bc51099b-7253-47a2-b4ae-9618d3e42c6b
> Record changed: 2026-10-13

# Atirmociclib

Highest phase reached

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5187755)

Drug type

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5187755)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5187755)

## Names and chemistry

**Drug type**

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5187755)

**Drug name**

Atirmociclib

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5187755)

**Molecular weight**

463.94

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5187755)

**Structure (SMILES)**

CC(C)n1c(C(C)(C)O)nc2c(F)cc(-c3nc(N\[C@@H\]4CCOC\[C@H\]4O)ncc3Cl)cc21

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5187755)

### Other names (17)

- atirmociclib
- Atirmociclib
- atirmociclib (PF-07220060)
- atirmociclib \[INN\]
- ATIRMOCICLIB \[USAN\]
- Atirmociclib \[WHO-DD\]
- atirmociclib inn
- atirmociclib usan
- atirmociclib who dd
- Oral PF-07220060
- pf 07220060
- Pf-07220060
- PF-07220060
- PF-07220060 100mg
- PF-07220060 300 mg
- pf07220060
- PF07220060

## Identifiers

**CAS registry numbers**

- 2380321-51-5

**ChEMBL ID**

CHEMBL5187755

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5187755)

**InChIKey**

QYJLBHRAPDJOSO-NVXWUHKLSA-N

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5187755)

**PubChem compound IDs**

- 146219790

**FDA ingredient codes (UNII)**

- S743GOJ5LJ

## Regulatory information

### Other regulatory facts

**First in class**

No

**Orphan designation**

No

## Pharmacology

### Drug classification

**Pharmacology name**

atirmociclib

**Type**

Synthetic organic

**Drug name stem**

\-ciclib

### Mechanisms of action (2)

- **Action**  
Inhibition

**Action type**  
Inhibitor

**Target**  
cyclin dependent kinase 4

**Gene symbol**  
CDK4

**Protein identifier**  
P11802

**Median affinity**

9.22

**Affinity units**  
pKi
- **Action**  
Inhibition

**Action type**  
Inhibitor

**Target**  
cyclin dependent kinase 6

**Gene symbol**  
CDK6

**Protein identifier**  
Q00534

**Median affinity**

7.86

**Affinity units**  
pKi

### Investigated indications (2)

- **Condition**  
Neoplasms

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0000616

**Subject identifier**  
D009369
- **Condition**  
Breast Neoplasms

**Highest recorded phase**  
2

**Condition identifier**  
MONDO:0007254

**Subject identifier**  
D001943

### Open Targets indications (9)

- **Condition identifier**  
EFO\_0000569

**Highest recorded phase**  
1
- **Condition identifier**  
EFO\_0000616
- **Condition identifier**  
MONDO\_0004992

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0005060

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0005070

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0005494

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0006244

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0007254

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0008315

**Highest recorded phase**  
1

### Trial references (2)

- NCT06206837  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06206837)
- NCT06465368  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06465368)

## Chemical properties

**Hydrogen bond acceptors**

8

**Hydrogen bond donors**

3

**Polar surface area**

105.32

**Calculated partition coefficient (ALogP)**

3.66

**Calculated partition coefficient (XLogP)**

2.3

**Prodrug**

No

**Chirality**

Single enantiomer

**Inorganic**

No

**Rule-of-five violations**

0

**Rotatable bonds**

5

**Heavy atoms**

32

**Molecular formula**

C22H27ClFN5O3

**Monoisotopic mass**

463.1786456

**Natural product**

No

## Evidence counts

**Recorded assays**

85

**Active assays**

23

### Active assay types

- Confirmatory

## Related records

### Trials (18)

- A Study Evaluating the Efficacy and Safety of Multiple Treatment Combinations in Patients With Metastatic or Locally Advanced Breast Cancer
- A Study to Compare Two Tablet Formulations of Study Medicine Atirmociclib in Healthy Participants
- A Study to Learn About How the Study Medicines Called Itraconazole and Probenecid Change How the Body Processes PF-07220060
- A Study to Learn About the Study Medicine (Called PF-07220060 in Combination With PF-07104091) In Participants With Breast Cancer and Solid Tumors
- [A Study to Learn About the Study Medicine Called PF-07220060 in Combination With Fulvestrant in People With HR-positive, HER2-negative Advanced or Metastatic Breast Cancer Who Progressed After a Prior Line of Treatment](https://trialight.com/data/trial/a-study-to-learn-about-the-study-medicine-called-pf-07220060-3822cbc0-ac5f-4715-96e6-6aecc3b3af83.md)
- A Study to Learn About the Study Medicine PF-07220060 Together With Letrozole Compared to Letrozole Alone in Women Post Menopause
- A Study to Learn About Vepdegestrant When Given With PF-07220060 to People With Advanced or Metastatic Breast Cancer.
- A Study to Learn How the Study Medicine Called Atirmociclib is Handled by the Body in People With Normal Liver Function and Different Levels of Liver Disease
- A Study to Learn if the Study Medicine Called Carbamazepine Changes How the Body Processes PF-07220060
- A Study to Understand What the Body Does to the Study Medicine Called PF-07220060 When Taken by Healthy Adults
- [First-in-Human Study of Mutant-selective PI3Kα Inhibitor, RLY-2608, as a Single Agent in Patients With Advanced Solid Tumors and in Combination With Endocrine Therapy +/- a CDK4/6 or CDK4 Inhibitor in Patients With Advanced Solid Tumors or Advanced Breast Cancer](https://trialight.com/data/trial/first-in-human-study-of-mutant-selective-pi3k-inhibitor-rly-9e76b9f6-c935-4570-b239-0dc9755a4b4e.md)
- [First-in-Human Study of OKI-219 in Advanced Solid Tumors and Advanced Breast Cancer](https://trialight.com/data/trial/first-in-human-study-of-oki-219-in-advanced-solid-tumors-and-cccc54ea-a51b-4bb9-9e9c-890bba2ff5c0.md)
- [Phase 1b Study of OP-1250 (Palazestrant) in Combination With Ribociclib, Alpelisib, Everolimus, or Atirmociclib in ER+, HER2- Breast Cancer](https://trialight.com/data/trial/phase-1b-study-of-op-1250-palazestrant-in-combination-with-746c22ad-90a4-44fb-89ce-ea1783413128.md)
- Study About Whether Atirmociclib/PF-07220060 Proportionally Increases Exposure as Dose Increases in Healthy Participants
- [Study of PF-07220060 With Letrozole in Adults With HR-positive HER2-negative Breast Cancer Who Have Not Received Anticancer Treatment for Advanced/Metastatic Disease](https://trialight.com/data/trial/study-of-pf-07220060-with-letrozole-in-adults-with-hr-86aab0d0-25dd-47a2-b805-582b999dd7f5.md)
- Study of PF-07248144 in Advanced or Metastatic Solid Tumors
- Study to Evaluate the Safety and Tolerability of Camizestrant in Combination With Atirmociclib in Women With Advanced Breast Cancer
- Study to Test the Safety and Tolerability of PF-07220060 in Participants With Advance Solid Tumors

### In development for (4)

- [Breast cancer](https://trialight.com/data/condition/breast-cancer-8ac10da3-93bd-54c5-a93b-265bc6699689.md) Phase 2
- [Liposarcoma](https://trialight.com/data/condition/liposarcoma-abb3db35-bc99-5580-ad73-f24a284f3706.md) Phase 1
- Neoplasm Phase 1
- [Prostate cancer](https://trialight.com/data/condition/prostate-cancer-3659fc70-617b-5868-a093-ae819ffc6755.md) Phase 1

---

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