> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/ataciguat-574a94b9-5b3b-41fb-9593-d8e6b1ad00f2
> Record changed: 2026-10-13

# Ataciguat

Highest phase reached

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2107729)

Drug type

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2107729)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2107729)

## Names and chemistry

**Drug type**

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2107729)

**Drug name**

Ataciguat

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2107729)

**Molecular weight**

576.51

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2107729)

**Structure (SMILES)**

O=C(Nc1ccc(S(=O)(=O)N2CCOCC2)cc1)c1cc(Cl)ccc1NS(=O)(=O)c1ccc(Cl)s1

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2107729)

### Other names (8)

- ataciguat
- Ataciguat
- ataciguat (HMR1766)
- Ataciguat (HMR1766)
- ataciguat \[INN\]
- Ataciguat \[WHO-DD\]
- ataciguat inn
- ataciguat who dd

## Identifiers

**CAS registry numbers**

- 254877-67-3

**ChEMBL ID**

CHEMBL2107729

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2107729)

**InChIKey**

PQHLRGARXNPFCF-UHFFFAOYSA-N

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2107729)

**PubChem compound IDs**

- 213037

**FDA ingredient codes (UNII)**

- QP166M390Q

## Regulatory information

### Other regulatory facts

**First in class**

No

**Orphan designation**

No

## Pharmacology

### Drug classification

**Pharmacology name**

ataciguat

**Type**

Synthetic organic

**Drug name stem**

\-ciguat

### Mechanisms of action (6)

- **Action**  
Activation

**Action type**  
ACTIVATION

**Target**  
Guanylyl cyclase, α1β1

**Gene symbol**  
GUCY1A1

**Protein identifier**  
Q02108
- **Action**  
Activation

**Action type**  
ACTIVATION

**Target**  
Guanylyl cyclase, α1β1

**Gene symbol**  
GUCY1B1

**Protein identifier**  
Q02153
- **Mechanism**  
Soluble guanylate cyclase activator

**Action type**  
ACTIVATOR

**Target**  
Soluble guanylate cyclase

**Protein identifier**  
O75343
- **Mechanism**  
Soluble guanylate cyclase activator

**Action type**  
ACTIVATOR

**Target**  
Soluble guanylate cyclase

**Protein identifier**  
P33402
- **Mechanism**  
Soluble guanylate cyclase activator

**Action type**  
ACTIVATOR

**Target**  
Soluble guanylate cyclase

**Protein identifier**  
Q02108
- **Mechanism**  
Soluble guanylate cyclase activator

**Action type**  
ACTIVATOR

**Target**  
Soluble guanylate cyclase

**Protein identifier**  
Q02153

### Open Targets mechanisms

- **Mechanism**  
Soluble guanylate cyclase activator

**Action type**  
ACTIVATOR

**Target**  
Soluble guanylate cyclase

### Investigated indications (3)

- **Condition**  
Aortic Valve Stenosis

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000266

**Subject identifier**  
D001024
- **Condition**  
Pain

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0003843

**Subject identifier**  
D010146
- **Condition**  
Intermittent Claudication

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0003876

**Subject identifier**  
D007383

### Open Targets indications (5)

- **Condition identifier**  
EFO\_0000266

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0003876

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0005762

**Highest recorded phase**  
2
- **Condition identifier**  
HP\_0012531

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0005386

**Highest recorded phase**  
2

### Trial references (4)

- NCT00443287  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00443287)
- NCT00799656  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00799656)
- NCT02049203  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02049203)
- NCT02481258  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02481258)

## Chemical properties

**Hydrogen bond acceptors**

7

**Hydrogen bond donors**

2

**Polar surface area**

121.88

**Calculated partition coefficient (ALogP)**

4.13

**Calculated partition coefficient (XLogP)**

4.2

**Prodrug**

No

**Chirality**

Achiral

**Inorganic**

No

**Rule-of-five violations**

1

**Rotatable bonds**

7

**Heavy atoms**

35

**Molecular formula**

C21H19Cl2N3O6S3

**Monoisotopic mass**

574.9813042

**Natural product**

Yes

## Evidence counts

**Recorded assays**

537

**Active assays**

73

### Active assay types (3)

- Confirmatory
- Screening
- Summary

## Pharmacologic actions

- Enzyme Activators  
Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D020536.html)

## Related records

### Trials (5)

- A Study Evaluating the Effects of Ataciguat (HMR1766) on Aortic Valve Calcification
- [Ataciguat for Slowing the Progression of Moderate Calcific Aortic Valve Stenosis: A Randomized, Placebo Controlled Study](https://trialight.com/data/trial/ataciguat-for-slowing-the-progression-of-moderate-calcific-07ba1b1d-8f00-4779-91cb-252b4484681b.md)
- Efficacy and Safety of HMR1766 in Patients With Fontaine Stage II Peripheral Arterial Disease
- Efficacy and Safety Study of Ataciguat Versus Placebo in Patients With Neuropathic Pain
- Safety of Ataciguat in Patients With Moderate Calcific Aortic Valve Stenosis

### In development for (2)

- [Aortic valve stenosis](https://trialight.com/data/condition/aortic-valve-stenosis-d3f1a482-d908-5993-8a6c-7daad057bb89.md) Phase 2
- Intermittent vascular claudication Phase 2

### Targets (4)

- [GUCY1A1](https://trialight.com/data/target/gucy1a1-fa373a9a-c82a-51bf-a065-1bf847618dea.md) Soluble guanylate cyclase activator
- [GUCY1A2](https://trialight.com/data/target/gucy1a2-84659966-fdab-54c1-bbcb-f1a403932799.md) Soluble guanylate cyclase activator
- [GUCY1B1](https://trialight.com/data/target/gucy1b1-efb171f0-be14-51e9-bd71-b4b02145719c.md) Soluble guanylate cyclase activator
- [GUCY1B2](https://trialight.com/data/target/gucy1b2-58818a23-8aae-525d-859d-88e1d5adf01d.md) Soluble guanylate cyclase activator

---

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