> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/atacicept-58997791-8042-4d0f-ac69-564cf9e78d1d
> Record changed: 2026-10-13

# Atacicept

Highest phase reached

Phase 3

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1742986)

Drug type

Protein

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1742986)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 3

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1742986)

## Names and chemistry

**Drug type**

Protein

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1742986)

**Drug name**

Atacicept

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1742986)

### Other names (25)

- atacicept
- Atacicept
- atacicept \[INN\]
- ATACICEPT \[MI\]
- ATACICEPT \[USAN\]
- Atacicept \[WHO-DD\]
- Atacicept 150 mg
- Atacicept 25 mg
- Atacicept 75 mg
- atacicept inn
- atacicept mi
- atacicept usan
- atacicept vymj
- atacicept who dd
- Atacicept-VYMJ
- fus mabfrag human igg1 fc rprotfrag o14836 tr13b human 30110
- FUS: MABFRAG HUMAN (IGG1 FC); RPROTFRAG O14836 (TR13B\_HUMAN) (30110)
- HUMAN TRANSMEMBRANE ACTIVATOR AND CAML INTERACTOR (TACI) -IMMUNOGLOBULIN G SUB(1) FC DOMAIN FUSION PROTEIN (FC5)
- human transmembrane activator and caml interactor taci immunoglobulin g sub 1 fc domain fusion protein fc5
- taci fc5
- taci ig
- TACI-FC5
- TACI-IG
- trutakna
- TRUTAKNA

## Identifiers

**CAS registry numbers**

- 845264-92-8

**ChEMBL ID**

CHEMBL1742986

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1742986)

**RxNorm IDs (RxCUI)**

- 2747209

**FDA ingredient codes (UNII)**

- K3D9A0ICQ3

## Regulatory information

### Other regulatory facts

**Patents**

0

**Designations**

1

**First in class**

No

**Fast track**

No

**Breakthrough designation**

Yes

**Orphan designation**

No

**Priority review**

No

**Orphan exclusivity**

No

**Accelerated approval**

No

## Pharmacology

### Drug classification

**Pharmacology name**

atacicept

**Type**

Peptide

**Drug name stem**

\-cept

### Mechanisms of action (2)

- **Mechanism**  
Tumor necrosis factor ligand superfamily member 13 inhibitor

**Action type**  
Inhibitor

**Target**  
Tumor necrosis factor ligand superfamily member 13

**Protein identifier**  
O75888
- **Mechanism**  
Tumor necrosis factor ligand superfamily member 13B inhibitor

**Action type**  
Inhibitor

**Target**  
Tumor necrosis factor ligand superfamily member 13B

**Protein identifier**  
Q9Y275

### Open Targets mechanisms (2)

- **Mechanism**  
Tumor necrosis factor ligand superfamily member 13 inhibitor

**Action type**  
Inhibitor

**Target**  
Tumor necrosis factor ligand superfamily member 13
- **Mechanism**  
Tumor necrosis factor ligand superfamily member 13B inhibitor

**Action type**  
Inhibitor

**Target**  
Tumor necrosis factor ligand superfamily member 13B

### Investigated indications (6)

- **Condition**  
Arthritis, Rheumatoid

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000685

**Subject identifier**  
D001172
- **Condition**  
Glomerulonephritis, IGA

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0004194

**Subject identifier**  
D005922
- **Condition**  
Lupus Nephritis

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0005761

**Subject identifier**  
D008181
- **Condition**  
Optic Neuritis

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0007405

**Subject identifier**  
D009902
- **Condition**  
Multiple Sclerosis

**Highest recorded phase**  
2

**Condition identifier**  
MONDO:0005301

**Subject identifier**  
D009103
- **Condition**  
Lupus Erythematosus, Systemic

**Highest recorded phase**  
2

**Condition identifier**  
MONDO:0007915

**Subject identifier**  
D008180

### Open Targets indications (16)

- **Condition identifier**  
EFO\_0000574

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0000685

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0004194

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0005761

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0007405

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0004670

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0005062

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0005301

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0005342

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0005556

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0005885

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0006835

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0007915
- **Condition identifier**  
MONDO\_0007915

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0008383

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0100313

**Highest recorded phase**  
2

### Reported adverse events

- **Event**  
blood immunoglobulin g decreased

**Reports**  
3

**Reporting signal score**

24.8817

### Trial references (15)

- NCT00430495  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00430495)
- NCT00595413  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00595413)
- NCT00664521  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00664521)
- NCT00573157  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00573157)
- NCT01369628  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01369628)
- NCT05609812  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05609812)
- NCT00624338  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00624338)
- NCT01440231  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01440231)
- NCT01972568  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01972568)
- NCT02070978  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02070978)
- NCT00624468  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00624468)
- NCT00642902  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00642902)
- NCT00853762  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00853762)
- NCT02808429  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02808429)
- NCT04716231  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04716231)

## Chemical properties

**Prodrug**

No

**Chirality**

Single enantiomer

**Inorganic**

No

**Natural product**

No

### Sequences

- **Component**  
Sequence

**Type**  
Protein

**Sequence**  
AMRSCPEEQYWDPLLGTCMSCKTICNHQSQRTCAAFCRSLSCRKEQGKFYDHLLRDCISCASICGQHPKQCAYFCENKLRSEPKSSDKTHTCPPCPAPEAEGAPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPSSIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK

## National Drug Codes

- 85052-101

## Related records

### Trials (19)

- A Phase 2 Dose-finding Study of Atacicept in Subjects With Rheumatoid Arthritis (AUGUST I)
- A Phase 2 Study of Atacicept in Subjects With Relapsing Multiple Sclerosis (ATAMS)
- [A Rollover Study to Evaluate the Long-Term Safety and Efficacy of Atacicept](https://trialight.com/data/trial/a-rollover-study-to-evaluate-the-long-term-safety-and-9dbe3a47-27e6-4d34-840c-23f919cece2a.md)
- Atacicept Demonstrating Dose RESponSe
- Atacicept in Anti-Tumor Necrosis Factor Alpha-naïve Subjects With Rheumatoid Arthritis (AUGUST II)
- Atacicept in Combination With Rituximab in Subjects With Rheumatoid Arthritis (August III)
- Atacicept in Lupus Nephritis Patients Taking Stable Regimen of Mycophenolate Mofetil
- Atacicept in Multiple Glomerular Diseases
- Atacicept in Multiple Sclerosis Extension Study, Phase II
- Atacicept in Subjects With Active Lupus Nephritis (COMPASS)
- Atacicept in Subjects With IgA Nephropathy
- Atacicept in Subjects With Optic Neuritis
- Atacicept Phase 2/3 in Generalized Systemic Lupus Erythematosus (APRIL-SLE)
- CD24Fc for the Treatment of Immune Related Adverse Events in Patients With Advanced Solid Tumors, TIRAEC Study
- Efficacy and Safety of Atacicept in IgA Nephropathy
- Efficacy and Safety of Atacicept in Systemic Lupus Erythematosus
- Long-term Safety and Tolerability of Atacicept (Long-term Follow-Up of Participant Who Participated in ADDRESS II)
- Monthly Dosing of Atacicept in IgAN
- The Efficacy and Safety of Atacicept in Combination With Mycophenolate Mofetil Used to Treat Lupus Nephritis

### In development for (8)

- [IgA glomerulonephritis](https://trialight.com/data/condition/iga-glomerulonephritis-f6f68a56-7253-54d9-9456-5d9ece4d1a52.md) Phase 3
- Lupus erythematosus Phase 2
- [Lupus nephritis](https://trialight.com/data/condition/lupus-nephritis-2794deed-1735-531d-b3ca-1e5d38aadc8a.md) Phase 3
- [Lymphoma](https://trialight.com/data/condition/lymphoma-de4db685-7419-5e0e-b958-4591ffd69d43.md) Phase 3
- [Multiple sclerosis](https://trialight.com/data/condition/multiple-sclerosis-62806c95-fe1b-529e-bd16-95cb92d15375.md) Phase 2
- Optic neuritis Phase 2
- [Rheumatoid arthritis](https://trialight.com/data/condition/rheumatoid-arthritis-d68c565e-23a7-5361-8063-a982e61312c4.md) Phase 2
- [Systemic lupus erythematosus](https://trialight.com/data/condition/systemic-lupus-erythematosus-6c9d074f-cc5f-588b-bf0c-6338d30c6eac.md) Phase 2

### Targets (2)

- [TNFSF13](https://trialight.com/data/target/tnfsf13-45f49145-416e-5e16-b03b-b1de0275c8c9.md) Tumor necrosis factor ligand superfamily member 13 inhibitor
- [TNFSF13B](https://trialight.com/data/target/tnfsf13b-a5ea2503-7758-5b9b-93fc-c033ce6f46e2.md) Tumor necrosis factor ligand superfamily member 13B inhibitor

---

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