> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/atabecestat-5f27c9d3-bd39-4d17-ae59-5b1150d56b6d
> Record changed: 2026-10-13

# Atabecestat

Highest phase reached

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3916243)

Drug type

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3916243)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3916243)

## Names and chemistry

**Drug type**

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3916243)

**Drug name**

Atabecestat

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3916243)

**Molecular weight**

367.41

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3916243)

**Structure (SMILES)**

C\[C@@\]1(c2cc(NC(=O)c3ccc(C#N)cn3)ccc2F)C=CSC(N)=N1

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3916243)

### Other names (35)

- atabecestat
- Atabecestat
- ATABECESTAT
- atabecestat \[INN\]
- ATABECESTAT \[USAN\]
- atabecestat inn
- atabecestat usan
- jnj 54861911
- jnj 54861911 aaa
- Jnj-54861911
- JNJ-54861911
- JNJ-54861911 (100 mg)
- JNJ-54861911 (25 mg)
- JNJ-54861911 (50 mg)
- JNJ-54861911 (Treatment A)
- JNJ-54861911 (Treatment B)
- JNJ-54861911 (Treatment C)
- JNJ-54861911 10 mg
- JNJ-54861911 160 mg
- JNJ-54861911 1mg
- JNJ-54861911 25 mg
- JNJ-54861911 27 mg
- JNJ-54861911 3 mg
- JNJ-54861911 30 mg
- JNJ-54861911 50 mg

And 10 more, listed on the interactive page.

## Identifiers

**CAS registry numbers**

- 1200493-78-2

**ChEMBL ID**

CHEMBL3916243

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3916243)

**InChIKey**

VLLFGVHGKLDDLW-SFHVURJKSA-N

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3916243)

**PubChem compound IDs**

- 68254185

**FDA ingredient codes (UNII)**

- 2834W8D6GK

## Regulatory information

### Other regulatory facts

**First in class**

No

**Orphan designation**

No

## Pharmacology

### Drug classification

**Pharmacology name**

atabecestat

**Type**

Synthetic organic

**Drug name stem**

\-stat

### Mechanisms of action (3)

- **Action**  
Inhibition

**Action type**  
Inhibitor

**Target**  
beta-secretase 1

**Gene symbol**  
BACE1

**Protein identifier**  
P56817

**Median affinity**

8.01

**Affinity units**  
pIC50
- **Action**  
Inhibition

**Action type**  
Inhibitor

**Target**  
beta-secretase 2

**Gene symbol**  
BACE2

**Protein identifier**  
Q9Y5Z0

**Median affinity**

8.02

**Affinity units**  
pKi
- **Mechanism**  
Beta-secretase 1 inhibitor

**Action type**  
Inhibitor

**Target**  
Beta-secretase 1

**Protein identifier**  
P56817

### Open Targets mechanisms

- **Mechanism**  
Beta-secretase 1 inhibitor

**Action type**  
Inhibitor

**Target**  
Beta-secretase 1

### Investigated indications

- **Condition**  
Alzheimer Disease

**Highest recorded phase**  
2

**Condition identifier**  
MONDO:0004975

**Subject identifier**  
D000544

### Open Targets indications (2)

- **Condition identifier**  
MONDO\_0004975
- **Condition identifier**  
MONDO\_0004975

**Highest recorded phase**  
2

### Trial references (5)

- NCT01978548  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01978548)
- NCT02260674  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02260674)
- NCT02360657  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02360657)
- NCT02406027  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02406027)
- NCT03587376  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03587376)

## Chemical properties

**Hydrogen bond acceptors**

6

**Hydrogen bond donors**

2

**Polar surface area**

104.16

**Calculated partition coefficient (ALogP)**

3.14

**Calculated partition coefficient (XLogP)**

2

**Prodrug**

No

**Chirality**

Single enantiomer

**Inorganic**

No

**Rule-of-five violations**

0

**Rotatable bonds**

3

**Heavy atoms**

26

**Molecular formula**

C18H14FN5OS

**Monoisotopic mass**

367.09030942

**Natural product**

No

## Evidence counts

**Recorded assays**

127

**Active assays**

22

### Active assay types

- Confirmatory

## Biological measurements

These details could not be displayed.

## Related records

### Trials (232)

- 3D1002 in Combination With Oxycodone Hydrochloride Sustained-release Tablets in Patients With Moderate to Severe Cancer Pain
- A Bioequivalence Study of Sacubitril/Valsartan Film-coated Tablets Under Fasting Conditions
- A Bioequivalence Study of the Fixed Dose Combination Tablets of Canagliflozin and Metformin Extended Release (XR) With Respect to the Individual Components
- A Bioequivalence Study of the Fixed Dose Combination Tablets of Canagliflozin and Metformin Extended Release (XR) With Respect to the Individual Components in Healthy Fed Participants
- A Clinical Trial Evaluating the Safety and Efficacy of AP1189 Versus Placebo as an add-on to Standard of Care in Participants With Respiratory Insufficiency Expected to be Caused by Infection With Respiratory Viruses
- A Crossover Study to Evaluate the Relative Oral Bioavailability and Food Effect After Single Dose Administration of JNJ-54861911 Tablet in Healthy Elderly Participants
- A Dose Ranging Escalation Study of Tramadol Hydrochloride in Healthy Volunteers
- A Dose Ranging Study to Evaluate the Safety and Efficacy of GSK2586184 in Patients With Chronic Plaque Psoriasis
- A Dose Response Study to Evaluate the Efficacy and Safety of Oral AP1189 Administered in Disease-Modifying Anti-Rheumatic Drug (DMARD) naïve Participants Participants With Early Rheumatoid Arthritis
- A Dose-range Study of the Safety and Efficacy of Treatment in Adult Rheumatoid Arthritis Patients With an Inadequate Response to Methotrexate
- A New Sildenafil Oral Film in Patients With Erectile Dysfunction
- A Pharmacokinetic and Pharmacodynamic Study of Once-Daily and Twice-Daily Dosing With Canagliflozin in Healthy Adult Volunteers
- A Pharmacokinetic Dose Proportionality Study of Canagliflozin in Healthy Volunteers
- A Pharmacokinetic Interaction Study Between JNJ-54861911 and Transporter Substrates Rosuvastatin and Metformin in Healthy Participants
- A Phase 1, Randomized Pharmacokinetics and Safety Study of Extended Duration Dapivirine Vaginal Rings
- A Phase 2A Study of a Novel Antimalarial Pyrrolidinamide in Adult Patients With Uncomplicated P. Falciparum Malaria
- A Phase 2a Study of TPN-101 in Patients With Progressive Supranuclear Palsy (PSP)
- A Phase 2A Study to Evaluate the Safety and Effect on Exercise Challenge Testing of MEDI-528 in Adults With Asthma
- A Phase 3 Study to Evaluate Efficacy and Safety of HDM1002 Tablets in Adults With Type 2 Diabetes Mellitus
- A Phase I Study of GFH312 in Healthy Chinese Subjects

### In development for (1)

- [Alzheimer disease](https://trialight.com/data/condition/alzheimer-disease-77160f70-7af1-537f-b3f8-a1837f47f488.md) Phase 2

### Targets (1)

- [BACE1](https://trialight.com/data/target/bace1-0881ab0a-c05f-5440-8172-f1d80cac05a7.md) Beta-secretase 1 inhibitor

---

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