> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/astegolimab-29ef649e-0460-44f8-91da-cd089a34950c
> Record changed: 2026-10-13

# Astegolimab

Highest phase reached

Phase 3

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4594385)

Drug type

Antibody

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4594385)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 3

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4594385)

## Names and chemistry

**Drug type**

Antibody

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4594385)

**Drug name**

Astegolimab

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4594385)

### Other names (30)

- amg 282
- AMG 282
- AMG-282
- amg282
- AMG282
- astegolimab
- Astegolimab
- astegolimab \[INN\]
- ASTEGOLIMAB \[USAN\]
- Astegolimab \[WHO-DD\]
- astegolimab inn
- astegolimab usan
- astegolimab who dd
- human mab that inhibits the binding of il 33 nf hev to il 1 receptor like 1
- HUMAN MAB THAT INHIBITS THE BINDING OF IL-33 (NF-HEV) TO IL-1 RECEPTOR-LIKE 1
- immunoglobulin g2 anti human interleukin 33 receptor human monoclonal mstt1041a gamma 2 chain disulfide with human monoclonal mstt1041a kappa chain dimer
- IMMUNOGLOBULIN G2, ANTI-(HUMAN INTERLEUKIN-33 RECEPTOR) (HUMAN MONOCLONAL MSTT1041A .GAMMA.2-CHAIN), DISULFIDE WITH HUMAN MONOCLONAL MSTT1041A .KAPPA.-CHAIN, DIMER
- immunoglobulin gx kappa anti homo sapiens interleukin 1 receptor like 1 protein st2 ec 3 2 2 6 homo sapiens monoclonal antibody gamma 2 heavy chain homo sapiens 1 447 homo sapiens vh ighv5 51 01 96 ighd ighj6 01 94 8 8 14 1 121 homo sapiens ighg2 01 122 447 135 214 disulfide with kappa light chain homo sapiens 1 214 v kappa homo sapiens igkv1 33 01 98 igkj4 01 6 3 9 1 107 homo sapiens igkc 01 108 214 dimer 223 223 224 224 227 227 230 230 tetrakisdisulfide
- IMMUNOGLOBULIN GX-KAPPA, ANTI-(HOMO SAPIENS INTERLEUKIN-1 RECEPTOR-LIKE 1 (PROTEIN ST2, EC=3.2.2.6)) HOMO SAPIENS MONOCLONAL ANTIBODY.GAMMA.2 HEAVY CHAIN HOMO SAPIENS (1-447) (HOMO SAPIENS VH (IGHV5-51\*01 (96%) (IGHD)-IGHJ6\*01 (94%)) (8.8.14) (1-121)-HOMO SAPIENS IGHG2\*01 (122-447)) (135-214')-DISULFIDE WITH .KAPPA. LIGHT CHAIN HOMO SAPIENS (1'-214') (V-KAPPA (HOMO SAPIENS IGKV1-33\*01 (98%) IGKJ4\*01)(6.3.9) (1'-107')-HOMO SAPIENS IGKC\*01 (108'-214')), DIMER (223-223'':224-224'':227-227'':230-230'')-TETRAKISDISULFIDE
- mstt 1041a
- MSTT-1041A
- mstt1041a
- Mstt1041a
- MSTT1041A
- rg 6149

And 5 more, listed on the interactive page.

## Identifiers

**CAS registry numbers**

- 2173054-79-8

**ChEMBL ID**

CHEMBL4594385

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4594385)

**FDA ingredient codes (UNII)**

- 27TW751DTH

## Regulatory information

### Other regulatory facts

**First in class**

No

**Orphan designation**

No

## Pharmacology

### Drug classification

**Drug name stem**

\-mab

### Mechanisms of action (2)

- **Mechanism**  
IL-33 receptor (ST2) inhibitor

**Action type**  
Inhibitor

**Target**  
IL-33 receptor (ST2)

**Protein identifier**  
Q01638
- **Mechanism**  
IL-33 receptor (ST2) inhibitor

**Action type**  
Inhibitor

**Target**  
IL-33 receptor (ST2)

**Protein identifier**  
Q9NPH3

### Open Targets mechanisms

- **Mechanism**  
IL-33 receptor (ST2) inhibitor

**Action type**  
Inhibitor

**Target**  
IL-33 receptor (ST2)

### Investigated indications (4)

- **Condition**  
Dermatitis, Atopic

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000274

**Subject identifier**  
D003876
- **Condition**  
Pulmonary Disease, Chronic Obstructive

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000341

**Subject identifier**  
D029424
- **Condition**  
Asthma

**Highest recorded phase**  
2

**Condition identifier**  
MONDO:0004979

**Subject identifier**  
D001249
- **Condition**  
Severe Acute Respiratory Syndrome

**Highest recorded phase**  
2

**Condition identifier**  
MONDO:0100096

**Subject identifier**  
D045169

### Open Targets indications (7)

- **Condition identifier**  
EFO\_0000274

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0000341

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_1002029

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0004979

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0004980

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0005002

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0100096

**Highest recorded phase**  
2

### Trial references (7)

- NCT02918019  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02918019)
- NCT03615040  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03615040)
- NCT05037929  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05037929)
- NCT05595642  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05595642)
- NCT05878769  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05878769)
- NCT03747575  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03747575)
- NCT04386616  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04386616)

## Chemical properties

**Prodrug**

No

**Chirality**

Single enantiomer

**Inorganic**

No

**Natural product**

No

### Sequences (5)

- **Component**  
Disulfide bridges location (isoform A)

**Sequence**  
22-96 $ 22''-96'' $ 23'-88' $ 23'''-88''' $ 134'-194' $ 134'''-194''' $ 135-214' $ 135''-214''' $ 148-204 $ 148''-204'' $ 223-223'' $ 224-224'' $ 227-227'' $ 230-230'' $ 261-321 $ 261''-321'' $ 367-425 $ 3670''-425''
- **Component**  
Light chain

**Type**  
Protein

**Sequence**  
DIQMTQSPSSLSASVGDRVTITCQASQDISNYLNWYQQKPGKAPKLLIYDASNLETGVPSRFSGSGSGTDFTFTISSLQPEDIATYYCQQDDNFPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC
- **Component**  
Heavy chain

**Type**  
Protein

**Sequence**  
EVQLVQSGAEVKKPGESLKISCKGSGYSFTNYWIGWVRQMPGKGLEWMGIIYPGNSDTRFSPSFQGQVTISADKSITTAYLQWSSLKASDTAMYYCARHGTSSDYYGLDVWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSNFGTQTYTCNVDHKPSNTKVDKTVERKCCVECPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTFRVVSVLTVVHQDWLNGKEYKCKVSNKGLPAPIEKTISKTKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPMLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
- **Component**  
Glycosylation sites (N)

**Sequence**  
Asn-297 $ Asn-297''''
- **Component**  
Glycosylation sites (N)

**Sequence**  
Asn-297 $ Asn-297''

## Related records

### Trials (10)

- A First-in-Human, Double Blind, Single Dose Study in Healthy Subjects and Subjects With Mild Atopic Asthma.
- A Study to Assess the Efficacy and Safety of MSTT1041A in Participants With Moderate to Severe Atopic Dermatitis
- A Study to Assess the Efficacy and Safety of MSTT1041A in Participants With Uncontrolled Severe Asthma
- [A Study to Evaluate Astegolimab in Participants With Chronic Obstructive Pulmonary Disease](https://trialight.com/data/trial/a-study-to-evaluate-astegolimab-in-participants-with-chronic-8e6922e8-89e1-4070-b3b2-33d3efcab415.md)
- A Study to Evaluate the Effect of Injection Site on PK of Astegolimab in Healthy Subjects
- A Study to Evaluate the Efficacy and Safety of Astegolimab in Participants With Chronic Obstructive Pulmonary Disease
- [A Study to Evaluate the Long-Term Safety of Astegolimab in Participants With Chronic Obstructive Pulmonary Disease (COPD)](https://trialight.com/data/trial/a-study-to-evaluate-the-long-term-safety-of-astegolimab-in-1671bf48-3835-4354-b78c-ff5ccbb9fc26.md)
- A Study to Evaluate the Safety and Efficacy of MSTT1041A (Astegolimab) or UTTR1147A in Patients With Severe COVID-19 Pneumonia
- A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AMG 282 in Healthy Subjects and Subjects With Chronic Rhinosinusitis With Nasal Polyps
- Anti-ST2 (MSTT1041A) in COPD (COPD-ST2OP)

### In development for (4)

- [Asthma](https://trialight.com/data/condition/asthma-247437fb-0e60-5885-8a3a-ce40099cea88.md) Phase 2
- [Atopic eczema](https://trialight.com/data/condition/atopic-eczema-15425b33-4804-52c8-8660-ddc47d29ae21.md) Phase 2
- [Chronic obstructive pulmonary disease](https://trialight.com/data/condition/chronic-obstructive-pulmonary-disease-8e23f74b-95b9-5920-a241-c0278555234f.md) Phase 3
- [COVID-19](https://trialight.com/data/condition/covid-19-13f0ebf3-c291-557d-bdef-93563d077103.md) Phase 2

### Targets (2)

- [IL1RAP](https://trialight.com/data/target/il1rap-140792ff-8cd2-58b9-81bd-4952f51389f6.md) IL-33 receptor (ST2) inhibitor
- [IL1RL1](https://trialight.com/data/target/il1rl1-dc683f4d-5537-5bcc-afbb-ef461a99c4ff.md) IL-33 receptor (ST2) inhibitor

---

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