> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/ask-120067-4e1a7a99-1d1b-4a22-8888-5b0863a9cb55
> Record changed: 2026-10-13

# ASK-120067

Highest phase reached

Phase 3

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068536)

Drug type

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068536)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 3

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068536)

## Names and chemistry

**Drug type**

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068536)

**Drug name**

ASK-120067

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068536)

**Molecular weight**

546.08

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068536)

**Structure (SMILES)**

C=CC(=O)Nc1cc(Nc2ncc(Cl)c(Nc3ccc4ccccc4c3)n2)c(OC)cc1N(C)CCN(C)C

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068536)

### Other names (5)

- ask 120067
- Ask-120067
- ask120067
- Ask120067
- ASK120067

## Identifiers

**CAS registry numbers**

- 1934259-00-3

**ChEMBL ID**

CHEMBL6068536

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068536)

**InChIKey**

QHPVTCLSVVUPOF-UHFFFAOYSA-N

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068536)

**PubChem compound IDs**

- 121371196

**FDA ingredient codes (UNII)**

- PRJ2UA27T7

## Regulatory information

### Other regulatory facts

**First in class**

No

**Orphan designation**

No

## Pharmacology

### Drug classification

**Pharmacology name**

limertinib

**Type**

Synthetic organic

**Approval recorded by Guide to Pharmacology**

Yes

### Mechanisms of action (3)

- **Action type**  
Inhibitor

**Target**  
epidermal growth factor receptor

**Gene symbol**  
epidermal growth factor receptor
- **Action**  
Inhibition

**Action type**  
Inhibitor

**Target**  
epidermal growth factor receptor

**Gene symbol**  
EGFR

**Protein identifier**  
P00533

**Median affinity**

8.22

**Affinity units**  
pIC50
- **Action**  
Inhibition

**Action type**  
Inhibitor

**Target**  
epidermal growth factor receptor

**Gene symbol**  
EGFR

**Protein identifier**  
P00533

**Median affinity**

9.3

**Affinity units**  
pIC50

### Investigated indications

- **Condition**  
Carcinoma, Non-Small-Cell Lung

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0003060

**Subject identifier**  
D002289

### Open Targets indications (4)

- **Condition identifier**  
EFO\_0003060

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0005233

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0008433

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0056806

**Highest recorded phase**  
2

### Trial references (3)

- NCT03502850  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03502850)
- NCT04143607  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04143607)
- NCT04360915  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04360915)

## Chemical properties

**Hydrogen bond acceptors**

8

**Hydrogen bond donors**

3

**Polar surface area**

94.65

**Calculated partition coefficient (ALogP)**

5.9

**Calculated partition coefficient (XLogP)**

5.7

**Prodrug**

No

**Chirality**

Achiral

**Inorganic**

No

**Rule-of-five violations**

2

**Rotatable bonds**

11

**Heavy atoms**

39

**Molecular formula**

C29H32ClN7O2

**Monoisotopic mass**

545.2306010

**Natural product**

No

## Related records

### Trials (5)

- ASK120067 Versus Gefitinib as First-line Treatment for EGFRm Locally Advanced or Metastatic NSCLC
- Assessing the Pharmacokinetics Effects of Food on ASK120067 in Single Oral Administration in Chinese Healthy Subjects
- Drug-drug Interaction Study Beteewn ASK120067 and Rifampicin or Itraconazole
- Safety, Tolerability, Pharmacokinetics and Anti-tumour Activity of ASK120067 in Locally Advanced and Metastatic Non Small Cell Lung Cancer
- [Study to Assess the Safety, Tolerability, Pharmacokinetics and Preliminary Anti-tumor Activity of ASKC202 With or Without ASK120067](https://trialight.com/data/trial/study-to-assess-the-safety-tolerability-pharmacokinetics-and-40ed5c8e-d99b-43c5-ae6c-3c21a41e44c6.md)

### In development for (1)

- [Non-small cell lung carcinoma](https://trialight.com/data/condition/non-small-cell-lung-carcinoma-a86c1d60-523f-5ea7-a5e1-39ed4a2296f8.md) Phase 3

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