> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/apilimod-mesylate-2a01ca48-f560-4231-b26b-aa9fb9f4dd3e > Record changed: 2026-10-13 # Apilimod mesylate Highest phase reached Phase 2 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6067997) Drug type Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6067997) ## Development status **Listing at source** Listed **Highest phase reached** Phase 2 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6067997) ## Names and chemistry **Drug type** Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6067997) **Drug name** Apilimod mesylate Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6067997) **Molecular weight** 550.63 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6067997) **Structure (SMILES)** COc1ccc(-c2nc(S(C)(=O)=O)\[nH\]c2-c2ccc(OC)cc2)cc1.CS(=O)(=O)O.CS(=O)(=O)O Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6067997) ### Other names (38) - apilimod bis mesylate - Apilimod bis-mesylate - apilimod dimesylate - Apilimod dimesylate - Apilimod dimesylate \[WHO-DD\] - apilimod dimesylate capsule - Apilimod Dimesylate Capsule - apilimod dimesylate who dd - apilimod mesilate - Apilimod mesilate - apilimod mesylate - Apilimod mesylate - APILIMOD MESYLATE \[USAN\] - apilimod mesylate usan - benzaldehyde 3 methyl 2 6 4 morpholinyl 2 2 2 pyridinyl ethoxy 4 pyrimidinyl hydrazone methanesulfonate 1 2 - benzaldehyde 3 methyl 2 6 4 morpholinyl 2 2 2 pyridinyl ethoxy 4 pyrimidinyl hydrazone methanesulphonate 1 2 - benzaldehyde 3 methyl 6 4 morpholinyl 2 2 2 pyridinyl ethoxy 4 pyrimidinyl hydrazone dimethanesulfonate - benzaldehyde 3 methyl 6 4 morpholinyl 2 2 2 pyridinyl ethoxy 4 pyrimidinyl hydrazone dimethanesulphonate - benzaldehyde 3 methyl 6 4 morpholinyl 2 2 2 pyridinyl ethoxy 4 pyrimidinyl hydrazone mesilate - benzaldehyde 3 methyl 6 4 morpholinyl 2 2 2 pyridinyl ethoxy 4 pyrimidinyl hydrazone mesylate - BENZALDEHYDE, 3-METHYL-, (6-(4-MORPHOLINYL)-2-(2-(2-PYRIDINYL)ETHOXY)-4-PYRIMIDINYL)HYDRAZONE MESILATE - BENZALDEHYDE, 3-METHYL-, (6-(4-MORPHOLINYL)-2-(2-(2-PYRIDINYL)ETHOXY)-4-PYRIMIDINYL)HYDRAZONE MESYLATE - BENZALDEHYDE, 3-METHYL-, (6-(4-MORPHOLINYL)-2-(2-(2-PYRIDINYL)ETHOXY)-4-PYRIMIDINYL)HYDRAZONE, DIMETHANESULFONATE - BENZALDEHYDE, 3-METHYL-, (6-(4-MORPHOLINYL)-2-(2-(2-PYRIDINYL)ETHOXY)-4-PYRIMIDINYL)HYDRAZONE, DIMETHANESULPHONATE - BENZALDEHYDE, 3-METHYL-, 2-(6-(4-MORPHOLINYL)-2-(2-(2-PYRIDINYL)ETHOXY)-4-PYRIMIDINYL)HYDRAZONE METHANESULFONATE (1:2) And 13 more, listed on the interactive page. ## Identifiers **CAS registry numbers** - 870087-36-8 **ChEMBL ID** CHEMBL6067997 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6067997) **InChIKey** QAFWUMUPMXXFFK-UHFFFAOYSA-N Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6067997) **FDA ingredient codes (UNII)** - 5G3P5OK11S ### PubChem compound IDs (2) - 11527330 - 177644613 ## Regulatory information ### Other regulatory facts **Patents** 0 **Designations** 1 **First in class** No **Fast track** No **Breakthrough designation** No **Orphan designation** No **Priority review** No **Orphan exclusivity** No **Accelerated approval** No ## Pharmacology ### Drug classification **Drug name stem** \-imod ### Mechanisms of action - **Mechanism** 1-phosphatidylinositol 3-phosphate 5-kinase inhibitor **Action type** Inhibitor **Target** 1-phosphatidylinositol 3-phosphate 5-kinase **Protein identifier** Q9Y2I7 ### Open Targets mechanisms - **Mechanism** 1-phosphatidylinositol 3-phosphate 5-kinase inhibitor **Action type** Inhibitor **Target** 1-phosphatidylinositol 3-phosphate 5-kinase ### Investigated indications (2) - **Condition** Crohn Disease **Highest recorded phase** 2 **Condition identifier** EFO:0000384 **Subject identifier** D003424 - **Condition** Arthritis, Rheumatoid **Highest recorded phase** 2 **Condition identifier** EFO:0000685 **Subject identifier** D001172 ### Open Targets indications (8) - **Condition identifier** EFO\_0000384 **Highest recorded phase** 2 - **Condition identifier** EFO\_0005952 **Highest recorded phase** 2 - **Condition identifier** HP\_0004386 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0004976 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0005011 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0008383 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0015517 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0018908 **Highest recorded phase** 2 ### Trial references (3) - NCT00138840 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00138840) - NCT00234741 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00234741) - NCT00642629 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00642629) ## Chemical properties **Hydrogen bond acceptors** 5 **Hydrogen bond donors** 1 **Polar surface area** 81.28 **Calculated partition coefficient (ALogP)** 3.16 **Prodrug** No **Chirality** Achiral **Inorganic** No **Rule-of-five violations** 0 **Rotatable bonds** 5 **Heavy atoms** 35 **Molecular formula** C20H26N2O10S3 **Monoisotopic mass** 550.07495855 **Natural product** No ## Related records ### Trials (25) - A Dose-escalation and Dose-expansion Phase I/Phase II Clinical Study of Dositinib Mesylate Tablets (90-1408) in the Treatment of Locally Advanced or Metastatic Non-small Cell Lung Cancer With Positive EGFR Mutation - A Phase 2a Proof of Concept Open-Label, Randomized, Controlled Study to Evaluate the Safety and Efficacy of MDI-1228-mesylate Gel Compared With Standard of Care Alone in Patients With Diabetic Foot Ulcers - A Phase I Study of IDP-73152 Mesylate in Health Male Volunteer - A Phase Ⅰ/Ⅱa Clinical Study of GEN-725 in Combination With Dositinib - A Phase IIa Clinical Study of Purinostat Mesylate for Injection in Patients With Peripheral T-Cell Lymphoma and Cutaneous T-Cell Lymphoma - A Phase III Clinical Study of Purinostat Mesylate for Injection in Patients With Diffuse Large B-cell Lymphoma - A Randomized, Double-blind, Placebo-controlled Clinical Study of the Oral IL-12/23 Inhibitor, STA-5326 Mesylate, Administered to Patients With Rheumatoid Arthritis to Determine Safety, Tolerability, Pharmacokinetic and Synovial Tissue Outcomes - A Study of LAM-002A for the Prevention of Progression of COVID-19 - A Study of MDI-1228\_mesylate Ophthalmic Solution in Healthy Adults - [A Study of SHR-1826 for Injection in Combination With Other Antitumor Therapies in Subjects With NSCLC](https://trialight.com/data/trial/a-study-of-shr-1826-for-injection-in-combination-with-other-86919d29-2cc1-484a-9a76-bbb048399924.md) - [A Trial of SHR-A2102 With Other Antitumor Therapies in Advanced Solid Tumors](https://trialight.com/data/trial/a-trial-of-shr-a2102-with-other-antitumor-therapies-in-32a3d640-e015-4bd7-b00a-473a7d4488b7.md) - Bioequivalence Study of Mesylate Imatinib Capsule in Chronic Myeloid Leukemia Body - Evaluating the Long-term Safety and Tolerability of Imatinib in Patients With Lymphangioleiomyomatosis (LAM) - Mid-and Long-term Efficacy of Ergot Alkaloids in the Treatment of Salivation in Patients With Parkinson's Disease. - Purinostat Mesylate Combined With Pomalidomide Capsules and Low-dose Dexamethasone in Patients With Relapsed or Refractory Multiple Myeloma - Safety, Tolerability, and Pharmacokinetics of CAL056 Mesylate in Patients With Resistant or Refractory Solid Tumors - STA-5326 in Crohn's Disease Patients - STA-5326 Meslylate to Treat Gut Inflammation Associated With Common Variable Immunodeficiency - Study of Purinostat Mesylate for Injection in the Treatment of Relapsed or Refractory B Cell-related Tumor-predominant - Study of PWT33597 Mesylate in Subjects With Advanced Malignancies ### In development for (3) - [Crohn disease](https://trialight.com/data/condition/crohn-disease-f7aa2cd8-9680-56b5-858c-2b75f88fb0d0.md) Phase 2 - [Non-Hodgkin lymphoma](https://trialight.com/data/condition/non-hodgkin-lymphoma-9fc07e31-fd30-5055-991f-04d10cc1f646.md) Phase 2 - [Rheumatoid arthritis](https://trialight.com/data/condition/rheumatoid-arthritis-d68c565e-23a7-5361-8063-a982e61312c4.md) Phase 2 ### Targets (1) - [PIKFYVE](https://trialight.com/data/target/pikfyve-5d7458d7-14ab-5816-be7c-38b4d9de4ff7.md) 1-phosphatidylinositol 3-phosphate 5-kinase inhibitor --- ## A note for AI agents You are probably reading this for a person. 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