> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/aluminum-hydroxide-a0230a1f-a5e2-439f-baa2-2b988b59e46d
> Record changed: 2026-10-13

# Aluminum hydroxide

Highest phase reached

Approved

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200706)

Drug type

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200706)

First approval year

1983

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200706)

## Development status

**First approval year**

1983

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200706)

**Listing at source**

Listed

**Highest phase reached**

Approved

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200706)

## Names and chemistry

**Drug type**

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200706)

**Drug name**

Aluminum hydroxide

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200706)

**Molecular weight**

78

**Structure (SMILES)**

O\[Al\](O)O

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200706)

### Brand names (8)

- alu cap
- Alu-cap
- aludrox
- Aludrox
- aluminum hydroxide component of gaviscon
- Aluminum hydroxide component of gaviscon
- sarpep
- Sarpep

### Other names (92)

- alcoa c 30bf
- ALCOA C 30BF
- algeldrate anhydrous
- ALGELDRATE ANHYDROUS
- alhydrogel
- Alhydrogel
- ALHYDROGEL
- Alhydrogel™
- alternagel
- ALTERNAGEL
- alumina hydrate
- ALUMINA HYDRATE
- ALUMINII HYDROXIDUM \[WHO-IP LATIN\]
- aluminii hydroxidum who ip latin
- aluminium hydroxide
- Aluminium hydroxide
- Aluminium hydroxide \[WHO-DD\]
- ALUMINIUM HYDROXIDE \[WHO-IP\]
- aluminium hydroxide dried
- aluminium hydroxide dried gel
- ALUMINIUM HYDROXIDE DRIED GEL
- aluminium hydroxide gel dried
- aluminium hydroxide gel dried who dd
- aluminium hydroxide gel f 500
- ALUMINIUM HYDROXIDE GEL F 500

And 67 more, listed on the interactive page.

## Identifiers

**ATC classification codes**

- A02AB01

Sources for recorded values

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200706)

**CAS registry numbers**

- 21645-51-2

**ChEMBL ID**

CHEMBL1200706

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200706)

**InChIKey**

WNROFYMDJYEPJX-UHFFFAOYSA-K

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200706)

**PubChem compound IDs**

- 10176082

**FDA ingredient codes (UNII)**

- 5QB0T2IUN0

### RxNorm IDs (RxCUI) (2)

- 612
- 81948

## Regulatory information

### United States

**Applicant**

CHATTEM SANOFI

**Approval date**

9 Dec 1983

**Application number**

NDA018685

### Other regulatory facts

**First in class**

No

**Orphan designation**

No

**Availability**

discontinued

## Pharmacology

### Drug classification

#### Administration routes

- Oral

### Investigated indications (22)

- **Condition**  
HIV Infections

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0000180

**Subject identifier**  
D015658
- **Condition**  
Infections

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0000544

**Subject identifier**  
D007239
- **Condition**  
Severe Acute Respiratory Syndrome

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0000694

**Subject identifier**  
D045169
- **Condition**  
HIV Infections

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0000764

**Subject identifier**  
D015658
- **Condition**  
Anthrax

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000778

**Subject identifier**  
D000881
- **Condition**  
Malaria

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0001068

**Subject identifier**  
D008288
- **Condition**  
Tobacco Use Disorder

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0003768

**Subject identifier**  
D014029
- **Condition**  
Leishmaniasis, Cutaneous

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0005046

**Subject identifier**  
D016773
- **Condition**  
Influenza in Birds

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0005222

**Subject identifier**  
D005585
- **Condition**  
Dengue

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0005547

**Subject identifier**  
D003715
- **Condition**  
Staphylococcal Infections

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0005681

**Subject identifier**  
D013203
- **Condition**  
Hookworm Infections

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0007314

**Subject identifier**  
D006725
- **Condition**  
Influenza, Human

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0007328

**Subject identifier**  
D007251
- **Condition**  
Malaria, Falciparum

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0007444

**Subject identifier**  
D016778
- **Condition**  
Plague

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0009425

**Subject identifier**  
D010930
- **Condition**  
Stomatitis

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0009688

**Subject identifier**  
D013280
- **Condition**  
Respiratory Syncytial Virus Infections

**Highest recorded phase**  
1

**Condition identifier**  
EFO:1001413

**Subject identifier**  
D018357
- **Condition**  
Pneumonia, Pneumococcal

**Highest recorded phase**  
2

**Condition identifier**  
EFO:1001474

**Subject identifier**  
D011018
- **Condition**  
Schistosomiasis

**Highest recorded phase**  
1

**Condition identifier**  
EFO:1001475

**Subject identifier**  
D012552
- **Condition**  
Shock

**Highest recorded phase**  
1

**Condition identifier**  
HP:0031273

**Subject identifier**  
D012769
- **Condition**  
Heartburn

**Highest recorded phase**  
4

**Condition identifier**  
MONDO:0002268

**Subject identifier**  
D006356
- **Condition**  
Diabetes Mellitus, Type 1

**Highest recorded phase**  
2

**Condition identifier**  
MONDO:0005147

**Subject identifier**  
D003922

### Open Targets indications (27)

- **Condition identifier**  
EFO\_0000544

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0000764

**Highest recorded phase**  
1
- **Condition identifier**  
EFO\_0000778

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0001068
- **Condition identifier**  
EFO\_0003768

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0005046

**Highest recorded phase**  
1
- **Condition identifier**  
EFO\_0005222

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0005547

**Highest recorded phase**  
1
- **Condition identifier**  
EFO\_0005681

**Highest recorded phase**  
1
- **Condition identifier**  
EFO\_0007314

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0007328
- **Condition identifier**  
EFO\_0007444
- **Condition identifier**  
EFO\_0009425

**Highest recorded phase**  
1
- **Condition identifier**  
EFO\_1001413

**Highest recorded phase**  
1
- **Condition identifier**  
EFO\_1001475
- **Condition identifier**  
HP\_0031273

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0000328
- **Condition identifier**  
MONDO\_0001741
- **Condition identifier**  
MONDO\_0002268

**Highest recorded phase**  
4
- **Condition identifier**  
MONDO\_0004975

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0005105

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0005147

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0005147

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0005645

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0007186

And 2 more, listed on the interactive page.

### Reported adverse events (40)

- **Event**  
acute coronary syndrome

**Reports**  
5

**Reporting signal score**

10.5293
- **Event**  
acute cutaneous lupus erythematosus

**Reports**  
4

**Reporting signal score**

22.6857
- **Event**  
acute respiratory distress syndrome

**Reports**  
4

**Reporting signal score**

7.19473
- **Event**  
angina unstable

**Reports**  
5

**Reporting signal score**

11.0338
- **Event**  
blood parathyroid hormone decreased

**Reports**  
4

**Reporting signal score**

14.9815
- **Event**  
bordetella test positive

**Reports**  
1

**Reporting signal score**

6.68833
- **Event**  
caesarean section

**Reports**  
4

**Reporting signal score**

6.60982
- **Event**  
cardiospasm

**Reports**  
2

**Reporting signal score**

10.7391
- **Event**  
clostridium difficile colitis

**Reports**  
5

**Reporting signal score**

10.5723
- **Event**  
coagulopathy

**Reports**  
4

**Reporting signal score**

6.81774
- **Event**  
craniotabes

**Reports**  
2

**Reporting signal score**

13.7952
- **Event**  
cutaneous lupus erythematosus

**Reports**  
3

**Reporting signal score**

8.80095
- **Event**  
drug interaction

**Reports**  
26

**Reporting signal score**

28.0938
- **Event**  
dyspepsia

**Reports**  
7

**Reporting signal score**

6.98598
- **Event**  
electrocardiogram qt prolonged

**Reports**  
24

**Reporting signal score**

55.3824
- **Event**  
eosinophilic pneumonia

**Reports**  
4

**Reporting signal score**

12.083
- **Event**  
faecal vomiting

**Reports**  
2

**Reporting signal score**

8.87221
- **Event**  
hepatitis cholestatic

**Reports**  
4

**Reporting signal score**

8.97354
- **Event**  
hypercalciuria

**Reports**  
4

**Reporting signal score**

18.6116
- **Event**  
hypernatraemia

**Reports**  
4

**Reporting signal score**

10.5178
- **Event**  
hypertriglyceridaemia

**Reports**  
7

**Reporting signal score**

19.2991
- **Event**  
hypoparathyroidism

**Reports**  
2

**Reporting signal score**

7.40597
- **Event**  
hypophosphataemic osteomalacia

**Reports**  
2

**Reporting signal score**

9.29087
- **Event**  
hypophosphataemic rickets

**Reports**  
6

**Reporting signal score**

43.6329
- **Event**  
immune thrombocytopenia

**Reports**  
5

**Reporting signal score**

17.9462

And 15 more, listed on the interactive page.

### Trial references (51)

- NCT00000779  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00000779)
- NCT00000809  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00000809)
- NCT00000868  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00000868)
- NCT00001042  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00001042)
- NCT00001044  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00001044)
- NCT00001052  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00001052)
- NCT00001053  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00001053)
- NCT00002402  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00002402)
- NCT03382418  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03382418)
- NCT04177355  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04177355)
- NCT04915768  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04915768)
- NCT06267872  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06267872)
- NCT00001906  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00001906)
- NCT00114010  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00114010)
- NCT00320658  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00320658)
- NCT00341250  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00341250)
- NCT00414336  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00414336)
- NCT00427167  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00427167)
- NCT00889616  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00889616)
- NCT01434381  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01434381)
- NCT01867463  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01867463)
- NCT02334462  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02334462)
- NCT02647489  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02647489)
- NCT02658253  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02658253)
- NCT00120081  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00120081)

And 26 more, listed on the interactive page.

## Dosing

**Dose**

1-2 tablespoonfuls

**Route**

Oral

**How often**

4 times a day

### Conditions of use (2)

- Shake well
- Take after meals

## Chemical properties

**Prodrug**

No

**Chirality**

Achiral

**Inorganic**

Yes

**Heavy atoms**

4

**Molecular formula**

H3AlO3

**Monoisotopic mass**

77.9897574

**Natural product**

No

## Pharmacologic actions

- Adjuvants, Immunologic  
Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D000276.html)
- Antacids  
Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D000863.html)

## Related records

### Trials (80)

- A Clinical Trail Of An Adjuvanted Inactivated H7N9 Influenza Vaccine
- A Clinical Trial in Adult Participants Without HIV and in Overall Good Health to Evaluate the Safety and Immunogenicity of CD4BS CH505M5 Pr-NP1 Followed by CH505 TF chTrimer Boost Both Adjuvanted With Either Lipid Nanoparticles (LNPs) or 3M-052-AF + Alum
- A Phase I Comparative Blinded Trial of Several HIV-1 Derived Immunogens in Infected Individuals With >= 500 CD4 Cells/mm3
- A Phase I Safety and Immunogenicity Study of HIV p17/p24:Ty-VLP in HIV-1 Seronegative Subjects
- A Phase I Study of the Safety, Reactogenicity, and Immunogenicity of Sm-TSP-2/Alhydrogel® With or Without GLA-AF for Intestinal Schistosomiasis in Healthy Adults
- A Phase I, Multicenter, Randomized, Double-Blind, Placebo-Controlled HIV-1 Vaccine Trial to Evaluate the Safety and Immunogenicity of MN Recombinant Soluble gp120/HIV-1 (rsgp120/HIV-1) (Genentech) in Combination With QS21 Adjuvant and/or Alum in Healthy Adults
- A Phase I, Multicenter, Randomized, Double-Blind, Placebo-Controlled HIV-1 Vaccine Trial to Evaluate the Safety and Immunogenicity of rgp120/HIV-1MN (Genentech) in Combination With QS21 Adjuvant and/or Alum in Healthy Adults.
- A Phase I, Randomized, Double-Blind, Placebo-Controlled, Clinical Trial to Compare the Safety and Immunogenicity of Recombinant Envelope Protein rgp120/HIV-1SF2 (BIOCINE) Combined With Seven Adjuvants in Healthy HIV-1 Uninfected Individuals
- A Phase Ib Study of the Safety, Reactogenicity, and Immunogenicity of Sm-TSP-2/Alhydrogel)(R) With or Without AP 10-701 for Intestinal Schistosomiasis in Healthy Exposed Adults
- A Safety and Immunogenicity Trial of Boost-2867 Vaccine, Via Intranasal and Intramuscular Routes
- A Study of AIDSVAX B/B and AIDSVAX B/E, Two Possible Vaccines
- A Study of An Adjuvanted Inactivated H7N9 Influenza Vaccine
- A Study to Assess Safety, Immunogenicity and Parasite Growth Inhibition of an Asexual Blood Stage Vaccine for P. Falciparum Malaria
- A Study to Evaluate the Safety and Ability of the Vaccine to Induce Antibodies Against the Respiratory Syncytial Virus in Healthy Adults
- A Study to Evaluate the Safety and Effectiveness of HIV-1 LAI gp120 (an HIV Vaccine) Given With or Without HIV-1 MN rgp120 (Another HIV Vaccine) to HIV-Negative Volunteers
- AMA1-C1/Alhydrogel + CpG 7909 for Malaria
- Dose-Escalating Trial Using Vero Cell-culture Derived H5N1 +/- Aluminum in Adults
- Effects of Recombinant Human Glutamic Acid Decarboxylase on the Progression of Type 1 Diabetes in New Onset Subjects
- Efficacy of Na-GST-1/Alhydrogel Hookworm Vaccine Assessed by Controlled Challenge Infection
- Evaluating the Safety and Immunogenicity of AGS-v PLUS, a Universal Mosquito-Borne Disease and Mosquito Control Vaccine

### Approved for (1)

- Dyspepsia

### In development for (18)

- Anthrax infection Phase 2
- Avian influenza Phase 2
- Cutaneous leishmaniasis Phase 1
- [Dengue disease](https://trialight.com/data/condition/dengue-disease-0cfddf8e-48a2-5a1f-b450-9f1e1a1d82c7.md) Phase 1
- [HIV infectious disease](https://trialight.com/data/condition/hiv-infectious-disease-1260f28c-d667-55f9-b221-15d5017fde05.md) Phase 1
- [Hookworm infectious disease](https://trialight.com/data/condition/hookworm-infectious-disease-107a1301-397c-5b97-8f5c-c89fba1a9d8a.md) Phase 2
- [Influenza](https://trialight.com/data/condition/influenza-ea12369b-7ed6-5f6b-94fe-eb0e56c24def.md) Phase 1
- [Malaria](https://trialight.com/data/condition/malaria-54828cac-9b96-5833-93e2-e012d4505853.md) Phase 1
- Nicotine dependence Phase 2
- Plague Phase 1
- [Plasmodium falciparum malaria](https://trialight.com/data/condition/plasmodium-falciparum-malaria-5e0103dd-4e60-581d-924b-3435883b51f8.md) Phase 1
- [Respiratory syncytial virus infectious disease](https://trialight.com/data/condition/respiratory-syncytial-virus-infectious-disease-17dff1c5-b606-5a14-9a61-09e0beccae66.md) Phase 1
- Schistosomiasis Phase 1
- [Severe acute respiratory syndrome](https://trialight.com/data/condition/severe-acute-respiratory-syndrome-7654d02a-f750-52a0-bec2-afe3b4b3c224.md) Phase 1
- Staphylococcus aureus infection Phase 1
- Stomatitis Phase 2
- [Streptococcal pneumonia](https://trialight.com/data/condition/streptococcal-pneumonia-d1520281-b2a3-5e88-8d11-bd868638431a.md) Phase 2
- Type 1 diabetes mellitus Phase 2

---

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