> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/aleniglipron-de94eeab-2748-4d16-98b0-aef79b483e8c
> Record changed: 2026-10-13

# Aleniglipron

Highest phase reached

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068040)

Drug type

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068040)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068040)

## Names and chemistry

**Drug type**

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068040)

**Drug name**

Aleniglipron

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068040)

**Molecular weight**

916.01

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068040)

**Structure (SMILES)**

CCP(=O)(CC)c1ccc(-n2ccn(-c3c4c(nn3-c3cc(C)c(F)c(C)c3)CCN(C(=O)c3cc5cc(C6CCOCC6)ccc5n3\[C@@\]3(c5nc(=O)o\[nH\]5)C\[C@@H\]3C)\[C@H\]4C)c2=O)cc1NC

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068040)

### Other names (14)

- aleniglipron
- Aleniglipron
- aleniglipron \[INN\]
- ALENIGLIPRON \[USAN\]
- aleniglipron inn
- aleniglipron usan
- gsbr 1001290
- gsbr 1290
- GSBR-1001290
- GSBR-1290
- gsbr1001290
- GSBR1001290
- gsbr1290
- GSBR1290

## Identifiers

**CAS registry numbers**

- 2685823-26-9

**ChEMBL ID**

CHEMBL6068040

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068040)

**InChIKey**

CPOJUYUGONJVPZ-WIXASUBBSA-N

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068040)

**PubChem compound IDs**

- 164809721

**FDA ingredient codes (UNII)**

- Z6XCL6R9SX

## Regulatory information

### Other regulatory facts

**First in class**

No

**Orphan designation**

No

## Pharmacology

### Drug classification

**Pharmacology name**

aleniglipron

**Type**

Synthetic organic

**Drug name stem**

\-glipron

### Mechanisms of action

- **Action**  
Full agonist

**Action type**  
FULL\_AGONIST

**Target**  
GLP-1 receptor

**Gene symbol**  
GLP1R

**Protein identifier**  
P43220

**Median affinity**  
10

**Affinity units**  
pEC50

### Open Targets indications (3)

- **Condition identifier**  
HP\_0001513

**Highest recorded phase**  
2
- **Condition identifier**  
HP\_0025502

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0005148

**Highest recorded phase**  
2

## Chemical properties

**Hydrogen bond acceptors**

13

**Hydrogen bond donors**

2

**Polar surface area**

167.21

**Calculated partition coefficient (ALogP)**

7.71

**Calculated partition coefficient (XLogP)**

6.7

**Prodrug**

No

**Chirality**

Single enantiomer

**Inorganic**

No

**Rule-of-five violations**

3

**Rotatable bonds**

11

**Heavy atoms**

66

**Molecular formula**

C49H55FN9O6P

**Monoisotopic mass**

915.39969567

**Natural product**

No

## Related records

### Trials (7)

- A Phase 2b, Dose-range Finding Study of the Efficacy and Safety of Multiple Doses of Aleniglipron (GSBR-1290) in Participants Living With Obesity or Overweight With at Least One Weight-related Comorbidity
- [A Study of Aleniglipron in Adults With Obesity or Overweight and Type 2 Diabetes Mellitus (ACCOMPLISH-2)](https://trialight.com/data/trial/a-study-of-aleniglipron-in-adults-with-obesity-or-overweight-b19a3b9d-468d-4958-8b0d-f97ca1fab44d.md)
- A Study of Multiple Ascending Doses of GSBR-1290 in Japanese and Non-Japanese Healthy Participants
- A Study of Multiple-ascending Doses of GSBR-1290 in Healthy Overweight/Obese Participants
- Aleniglipron Phase 2 in Type 2 Diabetes Mellitus
- [Efficacy and Safety of Aleniglipron in Participants With Obesity or Overweight With a Weight-Related Comorbidity (ACCOMPLISH-1)](https://trialight.com/data/trial/efficacy-and-safety-of-aleniglipron-in-participants-with-d91c444e-76ab-4255-8e93-1c86f7a8e44d.md)
- Phase 1b/2a Study of GSBR-1290 in Adult Overweight or Obese Healthy Subjects and Subjects With Type 2 Diabetes Mellitus

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