> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/alcohol-94acdb16-f595-4fd2-a9fa-0e1509bc9a8f
> Record changed: 2026-10-13

# Alcohol

Highest phase reached

Approved

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL545)

Drug type

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL545)

First approval year

1982

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL545)

## Development status

**First approval year**

1982

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL545)

**Listing at source**

Listed

**Highest phase reached**

Approved

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL545)

## Names and chemistry

**Drug type**

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL545)

**Drug name**

Alcohol

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL545)

**Molecular weight**

46.07

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL545)

**Structure (SMILES)**

CCO

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL545)

### Brand names (12)

- ablysinol
- Ablysinol
- alcohol component of avagard
- Alcohol component of avagard
- alcohol component of hbn 1 ethanol
- Alcohol component of hbn-1 ethanol
- methylated mineral
- Methylated mineral
- spirigel
- Spirigel
- surg
- Surg

### Other names (162)

- alcohol
- Alcohol
- Alcohol (Ethanol)
- Alcohol (oral)
- Alcohol (Oral)
- ALCOHOL \[HSDB\]
- ALCOHOL \[II\]
- ALCOHOL \[MART.\]
- ALCOHOL \[ORANGE BOOK\]
- ALCOHOL \[USP-RS\]
- ALCOHOL \[VANDF\]
- ALCOHOL \[WHO-IP\]
- alcohol 190 proof
- Alcohol 190 proof
- alcohol 95
- Alcohol 95%
- alcohol absolute
- alcohol anhydrous
- Alcohol anhydrous
- alcohol dehydrated
- alcohol dehydrated ii
- alcohol dehydrated vandf
- alcohol denat
- Alcohol denat.
- alcohol denatured

And 137 more, listed on the interactive page.

## Identifiers

**CAS registry numbers**

- 64-17-5

**ChEMBL ID**

CHEMBL545

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL545)

**InChIKey**

LFQSCWFLJHTTHZ-UHFFFAOYSA-N

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL545)

**PubChem compound IDs**

- 702

**RxNorm IDs (RxCUI)**

- 448

**FDA ingredient codes (UNII)**

- 3K9958V90M

### ATC classification codes (3)

- D08AX08
- V03AB16
- V03AZ01

Sources for recorded values

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL545)

## Regulatory information

### United States

**Applicant**

SOLVENTUM

**Approval date**

7 Jun 2001

**Application number**

NDA021074

### Other regulatory facts

**Patents**

0

**Designations**

2

**Earliest recorded loss of exclusivity**

23 Oct 2032

**First in class**

No

**Fast track**

No

**Breakthrough designation**

No

**Orphan designation**

No

**Priority review**

No

**Orphan exclusivity**

No

**Accelerated approval**

No

**Availability**

Over the counter

## Pharmacology

### Drug classification

**Pharmacology name**

ethanol

**Type**

Metabolite

#### Administration routes

- Parenteral
- topical

### Mechanisms of action (3)

- **Action type**  
ACTIVATION

**Target**  
TRPV6

**Gene symbol**  
TRPV6
- **Action**  
Activation

**Action type**  
ACTIVATION

**Target**  
TRPV6

**Gene symbol**  
TRPV6

**Protein identifier**  
Q9H1D0

**Median affinity**

0.82

**Affinity units**  
pEC50
- **Action**  
Potentiation

**Action type**  
POTENTIATION

**Target**  
Glycine Receptor (All subtypes)

**Gene symbol**  
Glycine Receptor (All subtypes)

### Investigated indications (43)

- **Condition**  
Atrial Fibrillation

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000275

**Subject identifier**  
D001281
- **Condition**  
Prostatic Hyperplasia

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0000284

**Subject identifier**  
D011470
- **Condition**  
Hypertension

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000537

**Subject identifier**  
D006973
- **Condition**  
Infections

**Highest recorded phase**  
4

**Condition identifier**  
EFO:0000544

**Subject identifier**  
D007239
- **Condition**  
Neuroblastoma

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0000621

**Subject identifier**  
D009447
- **Condition**  
Endometriosis

**Highest recorded phase**

0.5

**Condition identifier**  
EFO:0001065

**Subject identifier**  
D004715
- **Condition**  
Obesity

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0001073

**Subject identifier**  
D009765
- **Condition**  
Liver Cirrhosis

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0001422

**Subject identifier**  
D008103
- **Condition**  
Bacteremia

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0003033

**Subject identifier**  
D016470
- **Condition**  
Renal Insufficiency, Chronic

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0003884

**Subject identifier**  
D051436
- **Condition**  
Acne Vulgaris

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0003894

**Subject identifier**  
D000152
- **Condition**  
Erectile Dysfunction

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0004234

**Subject identifier**  
D007172
- **Condition**  
Alcohol Drinking

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0004329

**Subject identifier**  
D000428
- **Condition**  
Neurobehavioral Manifestations

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0004364

**Subject identifier**  
D019954
- **Condition**  
Tachycardia, Ventricular

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0005306

**Subject identifier**  
D017180
- **Condition**  
Marijuana Abuse

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0007191

**Subject identifier**  
D002189
- **Condition**  
Burns

**Highest recorded phase**  
4

**Condition identifier**  
EFO:0009516

**Subject identifier**  
D002056
- **Condition**  
Central Nervous System Neoplasms

**Highest recorded phase**  
2

**Condition identifier**  
EFO:1000158

**Subject identifier**  
D016543
- **Condition**  
Neoplasms, Cystic, Mucinous, and Serous

**Highest recorded phase**  
1

**Condition identifier**  
EFO:1000889

**Subject identifier**  
D018297
- **Condition**  
Prediabetic State

**Highest recorded phase**  
3

**Condition identifier**  
EFO:1001121

**Subject identifier**  
D011236
- **Condition**  
Pulpitis

**Highest recorded phase**

0.5

**Condition identifier**  
EFO:1001139

**Subject identifier**  
D011671
- **Condition**  
Herpes Labialis

**Highest recorded phase**  
2

**Condition identifier**  
EFO:1001347

**Subject identifier**  
D006560
- **Condition**  
Thyroid Nodule

**Highest recorded phase**  
1

**Condition identifier**  
EFO:1001436

**Subject identifier**  
D016606
- **Condition**  
Hyperhidrosis

**Highest recorded phase**  
1

**Condition identifier**  
HP:0000975

**Subject identifier**  
D006945
- **Condition**  
Tremor

**Highest recorded phase**  
2

**Condition identifier**  
HP:0001337

**Subject identifier**  
D014202

And 18 more, listed on the interactive page.

### Open Targets indications (80)

- **Condition identifier**  
EFO\_0000182
- **Condition identifier**  
EFO\_0000275

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0000284
- **Condition identifier**  
EFO\_0000537

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0000544
- **Condition identifier**  
EFO\_0000544

**Highest recorded phase**  
4
- **Condition identifier**  
EFO\_0000621

**Highest recorded phase**  
1
- **Condition identifier**  
EFO\_0000641
- **Condition identifier**  
EFO\_0000764
- **Condition identifier**  
EFO\_0001065
- **Condition identifier**  
EFO\_0003033

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0003884

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0003894

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0004234

**Highest recorded phase**  
1
- **Condition identifier**  
EFO\_0004318

**Highest recorded phase**  
1
- **Condition identifier**  
EFO\_0004329
- **Condition identifier**  
EFO\_0004364

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0005279
- **Condition identifier**  
EFO\_0005306

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0009516
- **Condition identifier**  
EFO\_0009516

**Highest recorded phase**  
4
- **Condition identifier**  
EFO\_0009574

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0010582
- **Condition identifier**  
EFO\_0801084
- **Condition identifier**  
EFO\_1000025

And 55 more, listed on the interactive page.

### Reported adverse events (63)

- **Event**  
acidosis

**Reports**  
32

**Reporting signal score**

56.0882
- **Event**  
aggression

**Reports**  
166

**Reporting signal score**

276.489
- **Event**  
agitation

**Reports**  
185

**Reporting signal score**

247.184
- **Event**  
alcohol abuse

**Reports**  
198

**Reporting signal score**

895.909
- **Event**  
alcohol interaction

**Reports**  
57

**Reporting signal score**

210.583
- **Event**  
alcohol poisoning

**Reports**  
101

**Reporting signal score**

415.255
- **Event**  
alcohol use

**Reports**  
92

**Reporting signal score**

316.015
- **Event**  
alcohol withdrawal syndrome

**Reports**  
32

**Reporting signal score**

113.401
- **Event**  
alcoholism

**Reports**  
48

**Reporting signal score**

121.54
- **Event**  
amnesia

**Reports**  
88

**Reporting signal score**

96.4713
- **Event**  
anti-cyclic citrullinated peptide antibody positive

**Reports**  
35

**Reporting signal score**

82.9541
- **Event**  
blood alcohol increased

**Reports**  
29

**Reporting signal score**

118.595
- **Event**  
blood creatine phosphokinase increased

**Reports**  
66

**Reporting signal score**

54.0256
- **Event**  
coma

**Reports**  
289

**Reporting signal score**

625.661
- **Event**  
completed suicide

**Reports**  
26

**Reporting signal score**

94.1595
- **Event**  
confusional state

**Reports**  
150

**Reporting signal score**

91.9908
- **Event**  
depressed level of consciousness

**Reports**  
89

**Reporting signal score**

95.5609
- **Event**  
drug abuse

**Reports**  
403

**Reporting signal score**

908.047
- **Event**  
drug abuser

**Reports**  
34

**Reporting signal score**

67.9682
- **Event**  
drug dependence

**Reports**  
179

**Reporting signal score**

391.717
- **Event**  
drug hypersensitivity

**Reports**  
836

**Reporting signal score**  
1,323.41
- **Event**  
drug screen positive

**Reports**  
32

**Reporting signal score**

63.7635
- **Event**  
drug use disorder

**Reports**  
28

**Reporting signal score**

57.0434
- **Event**  
drug withdrawal syndrome

**Reports**  
114

**Reporting signal score**

155.745
- **Event**  
duodenal ulcer perforation

**Reports**  
35

**Reporting signal score**

89.7073

And 38 more, listed on the interactive page.

### Trial references (78)

- NCT00001925  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00001925)
- NCT00006656  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00006656)
- NCT00009854  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00009854)
- NCT00037141  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00037141)
- NCT00247585  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00247585)
- NCT00290290  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00290290)
- NCT00680459  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00680459)
- NCT01101412  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01101412)
- NCT01472965  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01472965)
- NCT02227329  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02227329)
- NCT02577718  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02577718)
- NCT03083184  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03083184)
- NCT03253887  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03253887)
- NCT03640507  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03640507)
- NCT03757143  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03757143)
- NCT03838575  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03838575)
- NCT05268419  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05268419)
- NCT00295334  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00295334)
- NCT00437606  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00437606)
- NCT00471679  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00471679)
- NCT00563342  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00563342)
- NCT00616746  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00616746)
- NCT03294460  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03294460)
- NCT03361384  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03361384)
- NCT04159688  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04159688)

And 53 more, listed on the interactive page.

## Dosing

### Conditions of use (3)

- Discard after use
- Keep out of reach of children
- Use on hands when no soap and water available

## Chemical properties

**Hydrogen bond acceptors**

1

**Hydrogen bond donors**

1

**Polar surface area**

20.23

**Calculated partition coefficient (ALogP)**

0

**Calculated partition coefficient (XLogP)**

\-0.1

**Prodrug**

No

**Chirality**

Achiral

**Inorganic**

No

**Rule-of-five violations**

0

**Rotatable bonds**

0

**Heavy atoms**

3

**Molecular formula**

C2H6O

**Monoisotopic mass**

46.041864811

**Natural product**

Yes

## National Drug Codes

- 16729-710
- 50742-539
- 51991-999
- 54288-105
- 54288-144
- 55579-306
- 82983-426
- 83634-306
- 39822-9300
- 50090-7643

## Evidence counts

**Recorded assays**

3,468

**Active assays**

17

### Active assay types

- Other

## Pharmacologic actions

- Anti-Infective Agents, Local  
Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D000891.html)
- Central Nervous System Depressants  
Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D002492.html)
- Solvents  
Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D012997.html)

## Biological measurements

### Observed measurements

#### Distribution coefficient (LogD)

**Median**

\-0.31

**Mean**

\-0.31

**Minimum**

\-0.31

**Maximum**

\-0.31

**Unit**

unitless

**Assays**

1

**Standard deviation**

0

**Summary method**

median

**Censored results excluded**

0

**Other units excluded**

0

**Unknown units excluded**

0

#### Measurement types

- LogD

## Related records

### Trials (328)

- A Clinical Trial to Evaluate the Efficacy and Safety of CKD-495
- A Long-term Follow-up Study in Patients Who Received BEAM-101
- A Prospective Study of EUS Guided Celiac Block
- A Real-World Study of Pyrrolitinib Maleate Tablets for HER-2-Positive Early or Locally Advanced Breast Cancer After Adjuvant Trastuzumab Therapy
- A Study in Healthy Subjects to Determine the Effects When Alcohol is Administered With Perampanel
- A Study of a Hydrocolloid Bandage on Pimples
- A Study of ALKS 8700, a Monomethyl Fumarate (MMF) Molecule, in Healthy Adults
- A Study of Booster Immunization With COVID-19 Vaccine,Inactivated Co -Administration With Influenza Vaccine and Pneumococcal Polysaccharide Vaccine
- A Study of LY4057996 in Healthy Participants and Participants With Type 1 and Type 2 Diabetes
- A Study of the Hemodynamic Interactions of TPN171H Tablets & Alcohol in Healthy Male Subjects
- A Study of the Pharmacokinetics/Pharmacodynamics of GK Activator (2) in Type 2 Diabetes Patients With Hepatic Impairment.
- A Study to Assess Potential Interaction Between ASP8062 and Alcohol in Healthy Adult Subjects
- A Study to Assess the Effects of ACI-24.060 in Alzheimer's Disease and in Down Syndrome (ABATE Study)
- A Study to Assess the Pharmacodynamic Interaction Between Gabapentin and Ethanol in Healthy Subjects
- A Study to Determine the Influence of Co-ingestion of Alcohol on Hydrocodone Bitartrate Extended Release (HC-ER)
- [A Study to Evaluate the Immunogenicity and Safety of Nonavalent Human Papillomavirus (HPV) Vaccine](https://trialight.com/data/trial/a-study-to-evaluate-the-immunogenicity-and-safety-of-36e247e6-9cb9-47dd-8bf6-b2dd7d6a278a.md)
- A Systems Approach to Understanding Disease Processes in Multiple Sclerosis
- A Two-part Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Efficacy of KRP203 in Patients Undergoing Stem Cell Transplant for Hematological Malignancies
- A5288/MULTI-OCTAVE: Management Using Latest Technologies to Optimize Combination Therapy After Viral Failure
- Acute Effects of Alcohol on PET Imaging of Phosphodiesterase-4B (PDE4B)

### Approved for (1)

- Burn

### In development for (34)

- [Acne](https://trialight.com/data/condition/acne-02478aa3-966b-5ffb-a257-6dbe85c14e58.md) Phase 2
- [Alcohol abuse](https://trialight.com/data/condition/alcohol-abuse-de2eaa0d-f882-51b6-befd-e62533fe8ee1.md) Phase 3
- [Alcohol dependence](https://trialight.com/data/condition/alcohol-dependence-d26b3f0d-c0fb-5084-9194-e963df0e9179.md) Phase 3
- Alcohol-related disorders Phase 1
- [Alopecia](https://trialight.com/data/condition/alopecia-bb72324d-7d2e-5ac9-962f-2cdc0cf3ca73.md) Phase 2
- [Atrial fibrillation](https://trialight.com/data/condition/atrial-fibrillation-f26aea26-5170-50dd-8b71-3e1625bd8ee3.md) Phase 2
- Bacterial infectious disease with sepsis Phase 3
- Benign prostatic hyperplasia Phase 1
- Bipolar disorder Phase 2
- Cannabis dependence Phase 1
- [Central nervous system neoplasm](https://trialight.com/data/condition/central-nervous-system-neoplasm-bd35c306-06e5-549c-a882-45bdfbcbb7d8.md) Phase 2
- [Chronic kidney disease](https://trialight.com/data/condition/chronic-kidney-disease-dc1fecbb-338b-5bbc-8d68-08e49db49918.md) Phase 2
- [Cirrhosis of liver](https://trialight.com/data/condition/cirrhosis-of-liver-d90e4a84-9e82-54fc-a553-1e42086e8382.md) Phase 2
- Constipation disorder Phase 2
- [COVID-19](https://trialight.com/data/condition/covid-19-13f0ebf3-c291-557d-bdef-93563d077103.md) Phase 3
- Cystic, mucinous, and serous neoplasm Phase 1
- Dysmenorrhea Phase 2
- [Endometriosis](https://trialight.com/data/condition/endometriosis-3a5471b6-6d24-50b8-b1e6-8803dd78b0db.md) Early phase 1
- [Erectile dysfunction](https://trialight.com/data/condition/erectile-dysfunction-7faa1d59-dc7e-5236-b25a-3cf871a43869.md) Phase 1
- [Essential hypertension](https://trialight.com/data/condition/essential-hypertension-bd582df2-4596-58b0-aa00-37f10a4759d3.md) Phase 2

### Other linked conditions (6)

- [Cystitis](https://trialight.com/data/condition/cystitis-2c4484c3-baca-5bd7-a9f2-938dbb641710.md)
- [Hepatocellular carcinoma](https://trialight.com/data/condition/hepatocellular-carcinoma-fc1014ac-5a3c-551d-98ea-95306009e299.md)
- [HIV infectious disease](https://trialight.com/data/condition/hiv-infectious-disease-1260f28c-d667-55f9-b221-15d5017fde05.md)
- [Nosocomial infection](https://trialight.com/data/condition/nosocomial-infection-b3dd6ec1-3bfe-553c-b076-48a800eff89d.md)
- Temporomandibular joint disorder
- Thyroid gland papillary carcinoma

---

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