> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/aganirsen-b7c3d975-6d77-48ef-b4a4-71e2e3d5e09e
> Record changed: 2026-11-04

# Aganirsen

Highest phase reached

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2108296)

Drug type

Oligonucleotide

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2108296)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2108296)

## Names and chemistry

**Drug type**

Oligonucleotide

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2108296)

**Drug name**

Aganirsen

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2108296)

### Other names (10)

- (3'->5')D(P-THIO)(T-A-T-C-C-G-G-A-G-G-G-C-T-C-G-C-C-A-T-G-C-T G-C-T)
- 3 5 d p thio t a t c c g g a g g g c t c g c c a t g c t g c t
- aganirsen
- Aganirsen
- aganirsen \[INN\]
- Aganirsen \[WHO-DD\]
- aganirsen inn
- aganirsen who dd
- gs 101
- Gs-101

## Identifiers

**CAS registry numbers**

- 1146887-67-3

**ChEMBL ID**

CHEMBL2108296

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2108296)

**FDA ingredient codes (UNII)**

- 0N3FY8225K

## Regulatory information

### Other regulatory facts

**Patents**

0

**Designations**

1

**First in class**

No

**Fast track**

No

**Breakthrough designation**

No

**Orphan designation**

No

**Priority review**

No

**Orphan exclusivity**

No

**Accelerated approval**

No

## Pharmacology

### Drug classification

**Drug name stem**

\-rsen

### Mechanisms of action (2)

- **Mechanism**  
Insulin receptor substrate 1 mRNA antisense inhibitor

**Action type**  
ANTISENSE\_INHIBITOR

**Target**  
Insulin receptor substrate 1 mRNA

**Protein identifier**  
ENSG00000169047
- **Mechanism**  
Insulin receptor substrate 1 mRNA antisense inhibitor

**Action type**  
Inhibitor

**Target**  
Insulin receptor substrate 1 mRNA

**Protein identifier**  
ENSG00000169047

### Open Targets mechanisms

- **Mechanism**  
Insulin receptor substrate 1 mRNA antisense inhibitor

**Action type**  
ANTISENSE INHIBITOR

**Target**  
Insulin receptor substrate 1 mRNA

### Open Targets indications

- **Condition identifier**  
MONDO\_0004980

**Highest recorded phase**  
3

## Chemical properties

**Prodrug**

No

**Chirality**

Single enantiomer

**Inorganic**

No

**Natural product**

No

### Sequences

- **Component**  
Sequence

**Type**  
Nucleic Acid

**Sequence**  
(3'-5')D(P-THIO)>TATCCGGAGGGCTCGCCATGCTGCT

## Related records

### Trials (3)

- [A Phase 1 Clinical Study Comparing GS101 and Dupixent® After Subcutaneous Injection](https://trialight.com/data/trial/a-phase-1-clinical-study-comparing-gs101-and-dupixent-after-901f1eef-475a-47bb-94f7-9da51ce0e895.md)
- A Phase III Study of GS101 Injection to Dupixent®
- Trial of Aganirsen in iCRVO Patients at Risk of Developing NVG

### In development for (1)

- [Atopic eczema](https://trialight.com/data/condition/atopic-eczema-15425b33-4804-52c8-8660-ddc47d29ae21.md) Phase 3

### Targets (1)

- [IRS1](https://trialight.com/data/target/irs1-adc07240-de71-5558-971b-bf2953e2abca.md) Insulin receptor substrate 1 mRNA antisense inhibitor

---

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