> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/admilparant-c1bef0e8-811f-4442-9156-e70d2959785c
> Record changed: 2026-10-13

# Admilparant

Highest phase reached

Phase 3

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5087506)

Drug type

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5087506)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 3

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5087506)

## Names and chemistry

**Drug type**

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5087506)

**Drug name**

Admilparant

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5087506)

**Molecular weight**

445.52

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5087506)

**Structure (SMILES)**

CCCN(C)C(=O)OCc1c(-c2ccc(O\[C@H\]3CCC\[C@H\](C(=O)O)C3)c(C)n2)nnn1C

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5087506)

### Other names (18)

- admilparant
- Admilparant
- admilparant \[INN\]
- ADMILPARANT \[USAN\]
- admilparant inn
- admilparant usan
- bms 986 278
- bms 986278
- BMS 986278
- BMS 986278 \[WHO-DD\]
- bms 986278 who dd
- BMS-986,278
- Bms-986278
- BMS-986278
- BMS-986278 suspension
- BMS-986278 Tablet
- bms986278
- BMS986278

## Identifiers

**CAS registry numbers**

- 2170126-74-4

**ChEMBL ID**

CHEMBL5087506

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5087506)

**InChIKey**

UEUNDURNLYLSNB-HOTGVXAUSA-N

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5087506)

**PubChem compound IDs**

- 132232205

**FDA ingredient codes (UNII)**

- 4UN9AOU6G8

## Regulatory information

### Other regulatory facts

**Patents**

0

**Designations**

1

**First in class**

No

**Fast track**

No

**Breakthrough designation**

Yes

**Orphan designation**

No

**Priority review**

No

**Orphan exclusivity**

No

**Accelerated approval**

No

## Pharmacology

### Drug classification

**Pharmacology name**

BMS-986278

**Type**

Synthetic organic

### Mechanisms of action

- **Action**  
Antagonist

**Action type**  
Antagonist

**Target**  
LPA1 receptor

**Gene symbol**  
LPAR1

**Protein identifier**  
Q92633

**Median affinity**

8.16

**Affinity units**  
pKB

### Investigated indications (4)

- **Condition**  
Idiopathic Pulmonary Fibrosis

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000768

**Subject identifier**  
D054990
- **Condition**  
Liver Diseases

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0001421

**Subject identifier**  
D008107
- **Condition**  
Pulmonary Fibrosis

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0009448

**Subject identifier**  
D011658
- **Condition**  
Lung Diseases, Interstitial

**Highest recorded phase**  
1

**Condition identifier**  
HP:0006515

**Subject identifier**  
D017563

### Open Targets indications (5)

- **Condition identifier**  
EFO\_0000768

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0001421

**Highest recorded phase**  
1
- **Condition identifier**  
EFO\_0009448

**Highest recorded phase**  
3
- **Condition identifier**  
HP\_0006515
- **Condition identifier**  
MONDO\_0002771

**Highest recorded phase**  
3

### Trial references (5)

- NCT03981094  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03981094)
- NCT06003426  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06003426)
- NCT04308681  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04308681)
- NCT06025578  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06025578)
- NCT06425198  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06425198)

## Chemical properties

**Hydrogen bond acceptors**

8

**Hydrogen bond donors**

1

**Polar surface area**

119.67

**Calculated partition coefficient (ALogP)**

3.19

**Calculated partition coefficient (XLogP)**

2.1

**Prodrug**

No

**Chirality**

Single enantiomer

**Inorganic**

No

**Rule-of-five violations**

0

**Rotatable bonds**

8

**Heavy atoms**

32

**Molecular formula**

C22H31N5O5

**Monoisotopic mass**

445.23251911

**Natural product**

No

## Evidence counts

**Recorded assays**

70

**Active assays**

4

### Active assay types

- Confirmatory

## Biological measurements

### Observed measurements

#### Distribution coefficient (LogD)

**Median**

1.95

**Mean**

1.95

**Minimum**

1.95

**Maximum**

1.95

**Unit**

unitless

**Assays**

1

**Standard deviation**

0

**Summary method**

median

**Censored results excluded**

0

**Other units excluded**

0

**Unknown units excluded**

0

#### Measurement types

- LogD

#### Solubility

**Median**

4,601

**Mean**

4,601

**Minimum**

2,989

**Maximum**

6,213

**Unit**

ug/mL

**Assays**

2

**Standard deviation**

2,279.71

**Summary method**

median

**Censored results excluded**

0

**Other units excluded**

0

**Unknown units excluded**

0

#### Measurement types

- Solubility

#### Oral bioavailability

**Median**

79

**Mean**

83

**Minimum**

70

**Maximum**

100

**Unit**

%

**Assays**

3

**Standard deviation**

15.3948

**Summary method**

median

**Censored results excluded**

0

**Other units excluded**

0

**Unknown units excluded**

0

#### Measurement types

- F

## Related records

### Trials (20)

- A Study Investigating the Safety, Tolerability, Drug Levels and Drug Effect of BMS-986278 in Healthy Adult Participants (Part 1) and Japanese Participants (Part 2)
- A Study Measuring the Effectiveness, Safety, and Tolerability of BMS-986278 in Participants With Lung Fibrosis
- A Study of Experimental Medication BMS-986278 Given to Healthy Participants
- A Study of the Pharmacokinetic Interaction Between Pirfenidone and BMS-986278 in Healthy Participants
- A Study to Assess the Effect of Food on the Drug Levels of Admilparant
- A Study to Assess the Effect of Multiple Doses of Itraconazole, Gemfibrozil, or Carbamazepine on BMS-986278 in Healthy Participants
- A Study to Assess the Extent of Drug Interaction Between BMS-986278 and Nintedanib, the Relative Bioavailability of BMS-986278 in Tablet and the Effect That Food Has on BMS-986278 in Tablet Formulations in Healthy Participants
- A Study to Assess the Levels in Blood Plasma of BMS-986278 in Healthy Participants Following Administration of Tablets, With or Without Food, and in the Presence of an Antacid (Esomeprazole)
- A Study to Evaluate BMS-986278 in Participants With Normal Renal Function, Severe Renal Impairment, or End-Stage Renal Disease on Intermittent Hemodialysis
- A Study to Evaluate Comparative Bioavailability of BMS-986278 in Healthy Participants
- A Study to Evaluate the Drug Levels, Safety, and Tolerability of BMS-986278 in Healthy Chinese Participants
- A Study to Evaluate the Effect of BMS-986278 on Cardiac Repolarization in Healthy Participants
- [A Study to Evaluate the Efficacy, Safety, and Tolerability of BMS-986278 in Participants With Idiopathic Pulmonary Fibrosis](https://trialight.com/data/trial/a-study-to-evaluate-the-efficacy-safety-and-tolerability-of-385bdd36-bf32-4c87-b1aa-8e375a4007bf.md)
- [A Study to Evaluate the Efficacy, Safety, and Tolerability of BMS-986278 in Participants With Progressive Pulmonary Fibrosis](https://trialight.com/data/trial/a-study-to-evaluate-the-efficacy-safety-and-tolerability-of-2a9114f8-796b-4ef5-9065-1261441f4bfb.md)
- A Study to Investigate the Effects of BMS-986278 on Drospirenone and Ethinyl Estradiol Drug Levels in Healthy Female Participants
- A Study to Investigate the Safety, Tolerability, and Pharmacokinetics of BMS-986278 and the Effects of BMS-986278 on Cardiac Repolarization in Healthy Participants
- An Investigational Study of Experimental Medication BMS-986278 Given With the Antibiotic Rifampin in Healthy Participants
- Long-term Extension Study to Evaluate Safety and Tolerability of Admilparant in Participants With Pulmonary Fibrosis
- Study to Assess Drug Levels and Safety of BMS-986278 in Healthy Participants and Participants With Different Degrees of Hepatic Impairment
- Study to Assess the Way the Body Absorbs, Distributes, Breaks Down and Eliminates Radioactive BMS-986278 in Healthy Male Participants

### In development for (4)

- [Idiopathic pulmonary fibrosis](https://trialight.com/data/condition/idiopathic-pulmonary-fibrosis-9d400b0a-ada5-55c8-96c1-87bddcdf6913.md) Phase 3
- [Interstitial lung disease](https://trialight.com/data/condition/interstitial-lung-disease-745f5770-ba0b-517d-b691-5b9731a03266.md) Phase 1
- [Liver disorder](https://trialight.com/data/condition/liver-disorder-8388d30a-2581-5015-9ddf-adc5f6a331d7.md) Phase 1
- [Pulmonary fibrosis](https://trialight.com/data/condition/pulmonary-fibrosis-bc07081b-8a87-523b-80ff-c58435a000f3.md) Phase 3

---

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