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Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/adintrevimab-54fe54a2-887b-412b-94e4-d15b7c142b42 > Record changed: 2026-10-13 # Adintrevimab Highest phase reached Phase 2 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4802187) Drug type Antibody Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4802187) ## Development status **Listing at source** Listed **Highest phase reached** Phase 2 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4802187) ## Names and chemistry **Drug type** Antibody Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4802187) **Drug name** Adintrevimab Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4802187) ### Other names (18) - adg 20 - Adg 20 - ADG 20 \[WHO-DD\] - adg 20 who dd - ADG-20 - adg20 - Adg20 - ADG20 - adintrevimab - Adintrevimab - adintrevimab \[INN\] - ADINTREVIMAB \[USAN\] - adintrevimab inn - adintrevimab usan - Immunoglobulin G1 \[435-leucine,441-alanine\], anti-(severe acute respiratory syndrome coronavirus 2 spike glycoprotein) (human monoclonal ADG20 γ1-chain), disulfide with human monoclonal ADG20 λ-chain, dimer - immunoglobulin g1 435 leucine 441 alanine anti severe acute respiratory syndrome coronavirus 2 spike glycoprotein human monoclonal adg20 γ1 chain disulfide with human monoclonal adg20 λ chain dimer - immunoglobulin g1 lambda2 anti severe acute respiratory syndrome coronavirus 2 sars cov 2 spike s glycoprotein receptor binding domain rbd homo sapiens monoclonal antibody gamma1 heavy chain homo sapiens 1 454 vh homo sapiens ighv3 21 01 88 8 ighd ighj4 01 92 9 cdr imgt 8 8 17 26 33 51 58 97 113 1 124 homo sapiens ighg1 03 g1m3 ng1m1 g1v24 ch3 l107 s114 ch1 r120 221 125 222 hinge 1 15 223 237 ch2 238 347 ch3 e12 363 m14 365 m107 l 435 n114 a 441 348 452 chs 453 454 125 453 227 217 disulfide with lambda2 light chain homo sapiens 1 218 v lambda homo sapiens iglv1 40 01 95 9 iglj1 01 91 7 cdr imgt 9 3 12 26 34 52 54 91 102 1 112 homo sapiens iglc2 01 100 113 218 dimer 233 233 236 236 bisdisulfide produced in chinese hamster ovary cho cells glycoform alfa - Immunoglobulin G1-lambda2, anti-\[severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) glycoprotein, receptor binding domain (RBD)\], Homo sapiens monoclonal antibody; gamma1 heavy chain Homo sapiens (1-454) \[VH (Homo sapiens IGHV3-21\*01 (88.8%) -(IGHD) -IGHJ4\*01 (92.9%), CDR-IMGT \[8.8.17\] (26-33.51-58.97-113)) (1-124) -Homo sapiens IGHG1\*03, G1m3, nG1m1, G1v24 CH3 L107, S114 (CH1 R120 (221) (125-222), hinge 1-15 (223-237), CH2 (238-347), CH3 E12 (363), M14 (365), M107>L (435), N114>A (441) (348-452), CHS (453-454)) (125-453)\], (227-217')-disulfide with lambda2 light chain Homo sapiens (1'-218') \[V-LAMBDA (Homo sapiens IGLV1-40\*01 (95.9%) -IGLJ1\*01 (91.7%), CDR-IMGT \[9.3.12\] (26-34.52-54.91-102)) (1'-112') -Homo sapiens IGLC2\*01 (100%) (113'-218')\]; dimer (233-233'':236-236'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, glycoform alfa ## Identifiers **CAS registry numbers** - 2516243-54-0 **ChEMBL ID** CHEMBL4802187 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4802187) **FDA ingredient codes (UNII)** - 054Q5D7VZI ## Regulatory information ### Other regulatory facts **First in class** No **Orphan designation** No ## Pharmacology ### Drug classification **Drug name stem** \-mab ### Mechanisms of action - **Mechanism** Spike glycoprotein inhibitor **Action type** Inhibitor **Target** Spike glycoprotein **Protein identifier** P0DTC2 ### Open Targets mechanisms - **Mechanism** Spike glycoprotein inhibitor **Action type** Inhibitor **Target** Spike glycoprotein ### Investigated indications (2) - **Condition** COVID-19 **Highest recorded phase** 1 **Condition identifier** MONDO:0100096 **Subject identifier** D000086382 - **Condition** Severe Acute Respiratory Syndrome **Highest recorded phase** 2 **Condition identifier** MONDO:0100096 **Subject identifier** D045169 ### Open Targets indications (2) - **Condition identifier** MONDO\_0100096 - **Condition identifier** MONDO\_0100096 **Highest recorded phase** 2 ### Trial references (2) - NCT04805671 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04805671) - NCT04859517 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04859517) ## Chemical properties **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Natural product** No ### Sequences (6) - **Component** C-terminal lysine clipping **Sequence** 454 $ 454'' - **Component** Disulfide bridges **Sequence** 22'-90' $ 22'''-90''' $ 22-96 $ 22''-96'' $ 140'-199' $ 140'''-199''' $ 151-207 $ 151''-207'' $ 217'-227 $ 217'''-227'' $ 233-233'' $ 236-236'' $ 268-328 $ 268''-328'' $ 374-432 $ 374''-432'' - **Component** Heavy chain **Type** Protein **Sequence** EVQLVESGGGLVKPGGSLRLSCAASGFTFSSYYMNWVRQAPGKGLEWVSSISEDGYSTYYPDSLKGRFTISRDSAKNSLYLQMNSLRADDTAVYYCARDFSGHTAWAGTGFEYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVLHEALHAHYTQKSLSLSPGK - **Component** Glycosylation sites (N) **Sequence** 304 $ 304'''' - **Component** Light chain **Type** Protein **Sequence** QSVLTQPPSVSGAPGQRITISCTGSSSNIGAGYDVHWYQQLPGTAPKLLIYGSSSRNSGVPDRFSGSKSGTSASLAITGLQAEDEADYYCQSYDSSLSVLYTFGTGTKVTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS - **Component** Glycosylation sites (N) **Sequence** 304 $ 304'' ## Related records ### Trials (172) - A Cohort Study of SARS-CoV-2 Variant (Omicron BA.5) mRNA Vaccine in Participants Aged 18 Years and Over in Chinese People - A Phase I Clinical Trial to Evaluate the Safety, Tolerability, and Immunogenicity of SARS-CoV-2 Bivalent mRNA Vaccine (LVRNA021) - [A Phase II Clinical Trial to Evaluate the Immunogenicity and Safety of SARS-CoV-2 Bivalent mRNA Vaccine (LVRNA021)](https://trialight.com/data/trial/a-phase-ii-clinical-trial-to-evaluate-the-immunogenicity-and-491b99a0-2357-47d8-ba48-e3dbcaa16d2b.md) - [A Phase II/III Study to Evaluate the Immunogenicity and Safety and Efficacy of SWIM816 Vaccines for SARS-CoV-2](https://trialight.com/data/trial/a-phase-ii-iii-study-to-evaluate-the-immunogenicity-and-4ce18107-0366-4a3f-be68-497eb9b66066.md) - A Preliminary Exploratory Cohort Study of SARS-CoV-2 Variant (Omicron BA.5) mRNA Vaccine in Participants Aged 18 Years and Over in China - A Real-world Study to Evaluate the Safety and Immunogenicity of a Third-dose Booster After Two Doses of an Inactivated COVID-19 Vaccine - A Study Looking at the Effectiveness and Safety of a COVID-19 Vaccine in South African Adults - A Study Looking at the Effectiveness, Immune Response, and Safety of a COVID-19 Vaccine in Adults in the United Kingdom - A Study of an Investigational Flu Seasonal/SARS-CoV-2 Combination Vaccine in Adults - A Study on the Safety, Tolerability and Immune Response of SARS-CoV-2 Sclamp (COVID-19) Vaccine in Healthy Adults - A Study to Evaluate Safety & Immunogenicity of SARS-CoV-2 DNA Vaccine Delivered Intramuscularly Followed by Electroporation for COVID-19 - A Study to Evaluate Safety and Efficacy of Convalescent Methylene Blue Treated (MBT) Plasma From Donors Recovered From Coronavirus Disease 2019 (COVID-19) - A Study to Evaluate Safety, Tolerability, and Reactogenicity of an RBD-Fc-based Vaccine to Prevent COVID-19 - A Study to Evaluate the Efficacy, Immune Response, and Safety of a COVID-19 Vaccine in Adults ≥ 18 Years With a Pediatric Expansion in Adolescents (12 to<18 Years) at Risk for SARS-CoV-2 - A Study to Evaluate The Efficacy, Safety and Immunogenicity of Inactivated SARS-CoV-2 Vaccines (Vero Cell) in Healthy Population Aged 18 Years Old and Above - A Study to Evaluate the Efficacy, Safety and Immunogenicity of SARS-CoV-2 Vaccine (Vero Cells), Inactivated in Healthy Adults Aged 18 Years and Older (COVID-19) - [A Study to Evaluate the Safety and Immunogenicity of COVID-19 and Influenza Combination Vaccine](https://trialight.com/data/trial/a-study-to-evaluate-the-safety-and-immunogenicity-of-covid-6aadabe5-f3e0-4f16-afb7-fcdd6e12a2eb.md) - A Study to Learn About COVID-19 RNA-Based Variant-Adapted Vaccine Candidate(s) Against SARS-CoV-2 in Participants Ages 12 Through 64 Years Considered at Higher Risk of Severe COVID-19, and Participants Ages ≥65 Years - Administration of Anti-SARS-CoV-2 Convalescent Plasma in Hospitalized, Non-ICU Patients With COVID-19 - An Efficacy, Immunogenicity and Safety Study Investigating an Adjuvanted SARS-CoV-2 Influenza Vaccine to Protect Against COVID-19 in Adults Over Aged 18 Years-old and Older ### In development for (1) - [COVID-19](https://trialight.com/data/condition/covid-19-13f0ebf3-c291-557d-bdef-93563d077103.md) Phase 2 --- ## A note for AI agents You are probably reading this for a person. 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