> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/adenosine-phosphate-4407e198-7205-4ce3-890f-2eafe894e8e4
> Record changed: 2026-10-13

# Adenosine phosphate

Highest phase reached

Approved

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL752)

Drug type

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL752)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Approved

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL752)

## Names and chemistry

**Drug type**

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL752)

**Drug name**

Adenosine phosphate

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL752)

**Molecular weight**

347.22

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL752)

**Structure (SMILES)**

Nc1ncnc2c1ncn2\[C@@H\]1O\[C@H\](COP(=O)(O)O)\[C@@H\](O)\[C@H\]1O

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL752)

### Brand names (2)

- adenyl
- Adenyl

### Other names (48)

- 5 adenylic acid
- 5 adenylic acid fcc
- 5 adenylic acid mi
- 5 adenylic acid usp rs
- 5'-adenylic acid
- 5'-ADENYLIC ACID \[FCC\]
- 5'-ADENYLIC ACID \[MI\]
- 5'-ADENYLIC ACID \[USP-RS\]
- a 5mp
- A 5MP
- A-5MP
- adenosine 5 dihydrogen phosphate
- adenosine 5 monophosphoric acid
- ADENOSINE 5'-(DIHYDROGEN PHOSPHATE).
- Adenosine 5'-monophosphoric acid
- Adenosine Mono Phosphate (AMP)
- adenosine mono phosphate amp
- adenosine monophosphate
- Adenosine Monophosphate
- Adenosine monophosphate (amp)
- adenosine monophosphate amp
- adenosine phosphate
- Adenosine phosphate
- ADENOSINE PHOSPHATE \[HSDB\]
- adenosine phosphate \[INN\]

And 23 more, listed on the interactive page.

## Identifiers

**ATC classification codes**

- C01EB10

Sources for recorded values

Source: [mor.nlm.nih.gov](https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=296)

**CAS registry numbers**

- 61-19-8

**ChEMBL ID**

CHEMBL752

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL752)

**InChIKey**

UDMBCSSLTHHNCD-KQYNXXCUSA-N

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL752)

**PubChem compound IDs**

- 6083

**FDA ingredient codes (UNII)**

- 415SHH325A

### RxNorm IDs (RxCUI) (2)

- 296
- 309

## Regulatory information

### United States

**Applicant**

ASTELLAS

**Approval date**

30 Oct 1989

**Application number**

NDA019937

### Other regulatory facts

**First in class**

No

**Orphan designation**

No

**Availability**

Withdrawn

## Pharmacology

### Drug classification

**Pharmacology name**

adenosine 5'-monophosphate

**Type**

Metabolite

**Drug name stem**

\-nosine

### Mechanisms of action (3)

- **Action type**  
ACTIVATION

**Target**  
AMP kinase

**Gene symbol**  
AMP kinase
- **Action**  
Activation

**Action type**  
ACTIVATION

**Target**  
AMP kinase

**Gene symbol**  
AMP kinase

**Median affinity**

4.21

**Affinity units**  
pEC50
- **Action**  
Antagonist

**Action type**  
Antagonist

**Target**  
TRPM4

**Gene symbol**  
TRPM4

**Protein identifier**  
Q8TD43

**Median affinity**

4.7

**Affinity units**  
pIC50

### DrugCentral mechanisms

- **Action type**  
GATING INHIBITOR

**Gene symbol**  
TRPM4

**Protein identifier**  
Q8TD43

**Organism**  
Homo sapiens

**Target development level**  
Chemical evidence

### Investigated indications

- **Condition**  
Ischemia

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0000556

**Subject identifier**  
D007511

### Open Targets indications

- **Condition identifier**  
EFO\_0000556

**Highest recorded phase**  
1

### Warnings

- **Warning**  
Withdrawn

**Description**  
Not safe or effective for intended use as vasodilator, anti-inflammatory

**Year**  
1973

### Open Targets warnings (2)

- **Warning**  
Withdrawn

**Description**  
Not safe or effective for intended use as vasodilator, anti-inflammatory

**Year**  
1973

**Country**  
United States

**Condition**  
adverse effect
- **Warning**  
Withdrawn

**Description**  
Not safe or effective for intended use as vasodilator, anti-inflammatory

**Year**  
1973

**Country**  
United States

**Condition**  
lack of efficacy

### Reported adverse events

- **Event**  
drug hypersensitivity

**Reports**  
11

**Reporting signal score**

32.2162

### Trial references

- NCT00179010  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00179010)

## Dosing

**Dose**

10 drops

**Route**

Sublingual

**How often**

3 times a day

### Conditions of use

- As directed by your healthcare professional

## Chemical properties

**Hydrogen bond acceptors**

10

**Hydrogen bond donors**

5

**Polar surface area**

186.07

**Calculated partition coefficient (ALogP)**

\-1.86

**Calculated partition coefficient (XLogP)**

\-3.5

**Prodrug**

No

**Chirality**

Single enantiomer

**Inorganic**

No

**Rule-of-five violations**

0

**Rotatable bonds**

4

**Heavy atoms**

23

**Molecular formula**

C10H14N5O7P

**Monoisotopic mass**

347.06308480

**Natural product**

Yes

## Evidence counts

**Recorded assays**

958

**Active assays**

98

### Active assay types (4)

- Confirmatory
- Other
- Screening
- Summary

## Biological measurements

### Observed measurements

#### Solubility

**Median**

432,000

**Mean**

432,000

**Minimum**

432,000

**Maximum**

432,000

**Unit**

nM

**Assays**

1

**Standard deviation**

0

**Summary method**

median

**Censored results excluded**

0

**Other units excluded**

0

**Unknown units excluded**

0

#### Measurement types

- Solubility

## Related records

### Trials (84)

- A Dose Titration Study to Assess the Effects of SAR407899 in Patients With MVA and/or Persistent Stable Angina Despite Angiographically Successful PCI
- A Single Center Diagnostic, Cross-sectional Study of Coronary Microvascular Dysfunction
- [A Study on the Immune Response and Safety of an Investigational Combined Measles, Mumps, Rubella and Varicella Vaccine, When Administered as Intramuscular Injection to Healthy Children 15 Months to 6 Years of Age](https://trialight.com/data/trial/a-study-on-the-immune-response-and-safety-of-an-a4bde0bf-426f-44fd-8f34-15d639cc2197.md)
- A Trial to Compare American Heart Association (AHA) and Simple (SIM)Method to Give Adenosine to Treat Supra-ventricular Tachycardia (SVT)
- Adenosin to Rapidly Reverse Left Ventricle Impairment in Takotsubo Syndrome
- Adenosine and A2A Receptors in Human Brown Adipose Tissue
- Adenosine and Magnesium Sulphate as Adjuvants for PECS Block.
- Adenosine as an Adjunct to Blood Cardioplegia
- Adenosine Cardioplegia; Improved Cardioprotection?
- Adenosine Contrast CorrELations in Evaluating RevAscularizaTION
- Adenosine Effect on Persistent Pulmonary Vein Isolation Line Evaluation (APPLE Trial)
- Adenosine Receptors Influence Ischemia-Reperfusion Injury
- Adenosine to Assess Complete Conduction Block During Catheter Ablation of Paroxysmal Atrial Fibrillation
- Adenosine Versus Verapamil for Management of Supraventricular Tachycardia Post- Coronary Artery Bypass Grafting
- Adenosine vs Diltiazem for Treatment of SVT in the ED
- Adenosine vs. Diltiazem
- Adenosine's Effect on STunning Resolution in Acute Myocardial Infarction
- Adrenaline for the Treatment of No-Reflow in Normotensive Patients
- ADVANCE MPI 1: Study of Regadenoson Versus Adenoscan® in Patients Undergoing Myocardial Perfusion Imaging (MPI)
- ADVANCE MPI 2: Study of Regadenoson Versus Adenoscan® in Patients Undergoing Myocardial Perfusion Imaging (MPI)

### In development for (1)

- Ischemic disease Phase 1

---

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