> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/adebrelimab-047820dd-1777-483d-90ab-dd5fc86f78f6
> Record changed: 2026-10-13

# Adebrelimab

Highest phase reached

Phase 3

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297828)

Drug type

Antibody

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297828)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 3

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297828)

## Names and chemistry

**Drug type**

Antibody

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297828)

**Drug name**

Adebrelimab

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297828)

### Other names (21)

- Adebelimab (SHR-1316)
- adebelimab shr 1316
- adebrelimab
- Adebrelimab
- Adebrelimab (PD-L1 inhibitor)
- adebrelimab \[INN\]
- Adebrelimab \[WHO-DD\]
- Adebrelimab injection
- Adebrelimab Injection
- adebrelimab inn
- adebrelimab who dd
- anti pd l1 monoclonal antibody shr 1316
- ANTI-PD-L1 MONOCLONAL ANTIBODY SHR-1316
- hti 1088
- HTI-1088
- IMMUNOGLOBULIN G4 (52-GLYCINE,57-PHENYLALANINE,227-PROLINE,233-ALANINE,234-ALANINE), ANTI-(HUMAN PROGRAMMED CELL DEATH PROTEIN 1) (HUMAN-MUS MUSCULUS MONOCLONAL SHR-1316 .GAMMA.4-CHAIN), DISULFIDE WITH HUMAN-MUS MUSCULUS MONOCLONAL SHR-1316 .KAPPA.-CHAIN (85-GLUTAMIC ACID), DIMER
- immunoglobulin g4 52 glycine 57 phenylalanine 227 proline 233 alanine 234 alanine anti human programmed cell death protein 1 human mus musculus monoclonal shr 1316 gamma 4 chain disulfide with human mus musculus monoclonal shr 1316 kappa chain 85 glutamic acid dimer
- shr 1316
- Shr-1316
- SHR-1316
- SHR-1316 Injection

## Identifiers

**CAS registry numbers**

- 2247114-85-6

**ChEMBL ID**

CHEMBL4297828

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297828)

**FDA ingredient codes (UNII)**

- 1XBY50W1OX

## Regulatory information

### Other regulatory facts

**First in class**

No

**Orphan designation**

No

## Pharmacology

### Drug classification

**Pharmacology name**

adebrelimab

**Type**

Antibody

**Drug name stem**

\-mab

**Approval recorded by Guide to Pharmacology**

Yes

### Mechanisms of action (2)

- **Action**  
Binding

**Action type**  
Binding

**Target**  
programmed cell death 1 ligand 1

**Gene symbol**  
programmed cell death 1 ligand 1
- **Mechanism**  
Programmed cell death 1 ligand 1 inhibitor

**Action type**  
Inhibitor

**Target**  
Programmed cell death 1 ligand 1

**Protein identifier**  
Q9NZQ7

### Open Targets mechanisms

- **Mechanism**  
Programmed cell death 1 ligand 1 inhibitor

**Action type**  
Inhibitor

**Target**  
Programmed cell death 1 ligand 1

### Investigated indications (22)

- **Condition**  
Carcinoma, Squamous Cell

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000181

**Subject identifier**  
D002294
- **Condition**  
Carcinoma, Hepatocellular

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000182

**Subject identifier**  
D006528
- **Condition**  
Squamous Cell Carcinoma of Head and Neck

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000199

**Subject identifier**  
D000077195
- **Condition**  
Neoplasms

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0000616

**Subject identifier**  
D009369
- **Condition**  
Small Cell Lung Carcinoma

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000702

**Subject identifier**  
D055752
- **Condition**  
Carcinoma, Squamous Cell

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000707

**Subject identifier**  
D002294
- **Condition**  
Pancreatic Neoplasms

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0002618

**Subject identifier**  
D010190
- **Condition**  
Carcinoma, Non-Small-Cell Lung

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0003060

**Subject identifier**  
D002289
- **Condition**  
Ovarian Neoplasms

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0003893

**Subject identifier**  
D010051
- **Condition**  
Esophageal Neoplasms

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0005922

**Subject identifier**  
D004938
- **Condition**  
Rectal Neoplasms

**Highest recorded phase**  
2

**Condition identifier**  
EFO:1000657

**Subject identifier**  
D012004
- **Condition**  
Cholangiocarcinoma

**Highest recorded phase**  
2

**Condition identifier**  
EFO:1001961

**Subject identifier**  
D018281
- **Condition**  
Stomach Neoplasms

**Highest recorded phase**  
2

**Condition identifier**  
MONDO:0001056

**Subject identifier**  
D013274
- **Condition**  
Uterine Cervical Neoplasms

**Highest recorded phase**  
2

**Condition identifier**  
MONDO:0002974

**Subject identifier**  
D002583
- **Condition**  
Biliary Tract Neoplasms

**Highest recorded phase**  
2

**Condition identifier**  
MONDO:0003060

**Subject identifier**  
D001661
- **Condition**  
Adenocarcinoma

**Highest recorded phase**  
2

**Condition identifier**  
MONDO:0003219

**Subject identifier**  
D000230
- **Condition**  
Neoplasms

**Highest recorded phase**  
1

**Condition identifier**  
MONDO:0004992

**Subject identifier**  
D009369
- **Condition**  
Colorectal Neoplasms

**Highest recorded phase**  
1

**Condition identifier**  
MONDO:0005575

**Subject identifier**  
D015179
- **Condition**  
Breast Neoplasms

**Highest recorded phase**  
2

**Condition identifier**  
MONDO:0007254

**Subject identifier**  
D001943
- **Condition**  
Esophageal Neoplasms

**Highest recorded phase**  
2

**Condition identifier**  
MONDO:0007576

**Subject identifier**  
D004938
- **Condition**  
Prostatic Neoplasms, Castration-Resistant

**Highest recorded phase**  
2

**Condition identifier**  
MONDO:0008315

**Subject identifier**  
D064129
- **Condition**  
Nasopharyngeal Carcinoma

**Highest recorded phase**  
2

**Condition identifier**  
MONDO:0015459

**Subject identifier**  
D000077274

### Open Targets indications (73)

- **Condition identifier**  
EFO\_0000181

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0000182

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0000199

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0000503

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0000616
- **Condition identifier**  
EFO\_0000702

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0002618

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0003060

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0003860

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0005221

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0005922

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_1000359

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_1000657

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_1001480

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_1001901

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_1001961

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0000544

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0001056

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0001056

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0002108

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0002120

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0002691

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0002974

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0002974

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0003059

**Highest recorded phase**  
1

And 48 more, listed on the interactive page.

### Reported adverse events (11)

- **Event**  
alanine aminotransferase increased

**Reports**  
2

**Reporting signal score**

6.14689
- **Event**  
aspartate aminotransferase increased

**Reports**  
2

**Reporting signal score**

6.37947
- **Event**  
cerebral radiation injury

**Reports**  
1

**Reporting signal score**

11.1818
- **Event**  
endocrine disorder

**Reports**  
1

**Reporting signal score**

6.78159
- **Event**  
fatigue

**Reports**  
4

**Reporting signal score**

8.49937
- **Event**  
leukopenia

**Reports**  
3

**Reporting signal score**

11.4774
- **Event**  
pancreatic disorder

**Reports**  
1

**Reporting signal score**

5.84046
- **Event**  
pneumonitis

**Reports**  
2

**Reporting signal score**

8.35376
- **Event**  
rash

**Reports**  
3

**Reporting signal score**

6.34669
- **Event**  
thrombocytopenia

**Reports**  
3

**Reporting signal score**

9.10317
- **Event**  
vomiting

**Reports**  
3

**Reporting signal score**

6.08738

### Trial references (70)

- NCT03133247  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03133247)
- NCT03474289  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03474289)
- NCT04979390  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04979390)
- NCT05794477  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05794477)
- NCT05942378  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05942378)
- NCT06332170  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06332170)
- NCT06336707  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06336707)
- NCT06385678  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06385678)
- NCT06439589  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06439589)
- NCT03711305  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03711305)
- NCT04041011  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04041011)
- NCT04400188  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04400188)
- NCT04647357  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04647357)
- NCT06236997  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06236997)
- NCT06306560  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06306560)
- NCT06332950  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06332950)
- NCT06483282  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06483282)
- NCT03732508  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03732508)
- NCT03995472  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03995472)
- NCT05082545  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05082545)
- NCT06181032  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06181032)
- NCT04303988  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04303988)
- NCT06149130  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06149130)
- NCT06165900  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06165900)
- NCT06222879  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06222879)

And 45 more, listed on the interactive page.

## Chemical properties

**Prodrug**

No

**Inorganic**

No

**Natural product**

No

## Related records

### Trials (316)

- A Clinical Study of Adebrelimab Combined With Apatinib and Paclitaxel in Patients With Advanced Gastric Cancer.
- A Clinical Study of Adebrelimab in Combination With SHR-8068 and Chemoradiotherapy as Perioperative Therapy for Locally Advanced Rectal Cancer
- A Clinical Study of Recombinant Human Vascular Endothelial Inhibitor in Combination With PRaG for Advanced Refractory Non-small Cell Lung Cancer
- A Clinical Study of SHR-1316 (SC) Combined With Carboplatin and Etoposide as First-line Treatment for Extensive Stage Small Cell Lung Cancer
- A Clinical Study of SHR-8068 Combined With Adebrelimab and Bevacizumab Versus Sintilimab or Atezolizumab Combined With Bevacizumab for the Treatment of Advanced Hepatocellular Carcinoma
- A Clinical Study of SHR-A1811 Combined With Chemotherapy for Platinum Sensitive Recurrent Ovarian Cancer
- A Clinical Study of SHR-A1811 in the Treatment of HER2-positive Locally Advanced or Metastatic Biliary Tract Cancer
- A Clinical Trial of SHR-A1811 in the Treatment of Triple-negative Breast Cancer
- A Cohort Study of Incretin-based Therapy Combined With Insulin in Type 2 Diabetic Patients for 5 Years
- A Comparative Study of the Treatment of Real-world Patients With Clear Cell Carcinoma of the Ovary
- A Multicenter Real-World Cohort Study of Adebrelimab Injection in the Treatment of Extensive-Stage Small Cell Lung Cancer
- A Multicenter, Real-world Study of Adebrelimab in the Treatment of Extensive Stage Small Cell Lung Cancer
- A Pan-RAS Inhibitor in Combination With Anti-Tumor Therapy in Participants With Advanced Pancreatic Cancer
- A Phase I Study of HRS2300 or Combined With SHR-1316 or SHR-1701 or Trametinib or Almonertinib in Patients With Advanced Malignancies
- [A Phase Ib Study of HS-10370 in Addition to Other Anti-cancer Therapies in Participants with KRAS G12C Mutation Advanced Solid Tumors](https://trialight.com/data/trial/a-phase-ib-study-of-hs-10370-in-addition-to-other-anti-55df0ed7-4c94-4536-9aaf-e16363b5e264.md)
- [A Phase Ib Study of HS-10370 in Addition to Other Anti-cancer Therapies in Patients With Advanced Solid Tumors](https://trialight.com/data/trial/a-phase-ib-study-of-hs-10370-in-addition-to-other-anti-43ddeec6-71c0-43e8-a722-471e4b7615ed.md)
- A Phase IB/II Clinical Study of SHR-9839 for Injection Combined With Other Anti-tumor Therapies in Patients With Advanced Solid Tumors
- A Phase Ib/II Study of Adebrelimab in Combination with Capecitabine and Oxaliplatin in Cancer
- A Phase Ⅱ Clinical Study of Adebrelimab Combined With Chemotherapy and Concurrent Radiotherapy for Extensive-Stage Oligometastatic SCLC
- A Phase II Clinical Study of FH-006 for Injection Combined With Other Anticancer Therapies in Subjects With Lung Cancer

### In development for (28)

- [Biliary tract cancer](https://trialight.com/data/condition/biliary-tract-cancer-6b9535c9-ccaa-5b47-8c46-0d05d39d7c62.md) Phase 2
- [Breast cancer](https://trialight.com/data/condition/breast-cancer-8ac10da3-93bd-54c5-a93b-265bc6699689.md) Phase 2
- [Cancer](https://trialight.com/data/condition/cancer-703b1dfc-4812-50eb-83f4-d7a205d16bdb.md) Phase 1
- [Cervical cancer](https://trialight.com/data/condition/cervical-cancer-10fb8f6c-5aac-5281-8f06-7238adeec443.md) Phase 2
- [Cholangiocarcinoma](https://trialight.com/data/condition/cholangiocarcinoma-3777afe4-5189-5eb1-82f8-0c3446cb902f.md) Phase 2
- [Colorectal cancer](https://trialight.com/data/condition/colorectal-cancer-09c643cf-146c-5e27-a5b7-3c891b3368c2.md) Phase 1
- [Esophageal cancer](https://trialight.com/data/condition/esophageal-cancer-a3b5271c-e6d4-537b-8dfd-9391c60e2af2.md) Phase 2
- [Esophageal squamous cell carcinoma](https://trialight.com/data/condition/esophageal-squamous-cell-carcinoma-c10bd9c9-02f9-5805-8008-b021f4604e7a.md) Phase 2
- Exocrine pancreatic carcinoma Phase 2
- [Gastric adenocarcinoma](https://trialight.com/data/condition/gastric-adenocarcinoma-6bb74a55-7ba6-53e3-a113-22296a84d6ae.md) Phase 2
- [Gastric cancer](https://trialight.com/data/condition/gastric-cancer-3c1e2785-2672-5b3e-afce-9335f684c159.md) Phase 2
- [Gastroesophageal junction adenocarcinoma](https://trialight.com/data/condition/gastroesophageal-junction-adenocarcinoma-de7e280e-cbd1-5266-a5dd-dda00261a706.md) Phase 2
- [Head and neck squamous cell carcinoma](https://trialight.com/data/condition/head-and-neck-squamous-cell-carcinoma-cbc3ae58-4a6c-52e4-a41b-274051db19fa.md) Phase 2
- [Hepatocellular carcinoma](https://trialight.com/data/condition/hepatocellular-carcinoma-fc1014ac-5a3c-551d-98ea-95306009e299.md) Phase 2
- Intrahepatic cholangiocarcinoma Phase 2
- [Malignant pancreatic neoplasm](https://trialight.com/data/condition/malignant-pancreatic-neoplasm-5dd0b53e-5962-50ea-a2e5-cf2444bd0485.md) Phase 2
- [Nasopharyngeal carcinoma](https://trialight.com/data/condition/nasopharyngeal-carcinoma-9ead4a97-f794-5dda-b62e-20f8ca202f89.md) Phase 2
- Neoplasm Phase 1
- [Neuroendocrine neoplasm](https://trialight.com/data/condition/neuroendocrine-neoplasm-ab85715e-e4fa-5698-91d9-024cf0bab33c.md) Phase 2
- [Non-small cell lung carcinoma](https://trialight.com/data/condition/non-small-cell-lung-carcinoma-a86c1d60-523f-5ea7-a5e1-39ed4a2296f8.md) Phase 2

### Targets (1)

- [CD274](https://trialight.com/data/target/cd274-67467e37-9325-584a-be55-e3ef69f22b4c.md) Programmed cell death 1 ligand 1 inhibitor

---

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