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Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/abelacimab-d62f1002-e47d-46c4-b7b4-807b74b3a1f1 > Record changed: 2026-10-13 # Abelacimab Highest phase reached Phase 3 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4650369) Drug type Antibody Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4650369) ## Development status **Listing at source** Listed **Highest phase reached** Phase 3 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4650369) ## Names and chemistry **Drug type** Antibody Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4650369) **Drug name** Abelacimab Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4650369) ### Other names (14) - abelacimab - Abelacimab - abelacimab \[INN\] - ABELACIMAB \[USAN\] - Abelacimab \[WHO-DD\] - abelacimab inn - abelacimab usan - abelacimab who dd - immunoglobulin g1 anti human blood coagulation factor xi human monoclonal clone nvs250519 gamma 1 chain disulfide with human monoclonal nvs250519 lambda chain dimer - immunoglobulin g1 lambda anti homo sapiens f11 coagulation factor xi fxi plasma thromboplastin antecedent pta homo sapiens monoclonal antibody gamma1 heavy chain 1 452 homo sapiens vh ighv3 23 01 93 9 ighd ighj4 01 100 8 8 15 1 122 homo sapiens ighg1 03 g1m3 ng1m1 ch1 r120 219 123 220 hinge 221 235 ch2 d27 a 270 p114 a 334 236 345 ch3 e12 361 m14 363 346 450 chs 451 452 123 452 225 215 disulfide with lambda light chain 1 216 homo sapiens v lambda iglv1 44 01 93 5 iglj2 01 100 8 3 11 1 110 homo sapiens iglc2 01 111 216 dimer 231 231 234 234 bisdisulfide - immunoglobulin G1-lambda, anti-\[Homo sapiens F11 (coagulation factor XI, FXI, plasma thromboplastin antecedent, PTA)\], Homo sapiens monoclonal antibody; gamma1 heavy chain (1-452) \[Homo sapiens VH (IGHV3-23\*01 (93.9%) -(IGHD) IGHJ4\*01 (100%)) \[8.8.15\] (1-122) -Homo sapiens IGHG1\*03, G1m3, nG1m1 (CH1 R120 (219) (123-220), hinge (221-235), CH2 D27>A (270), P114>A (334) (236-345), CH3 E12 (361), M14 (363) (346-450), CHS (451-452)) (123-452)\], (225-215')disulfide with lambda light chain (1'-216') \[Homo sapiens V-LAMBDA (IGLV1-44\*01 (93.5%) -IGLJ2\*01 (100%)) \[8.3.11\] (1'-110') -Homo sapiens IGLC2\*01 (111'-216')\]; dimer (231-231'':234-234'')-bisdisulfide - IMMUNOGLOBULIN G1, ANTI-(HUMAN BLOOD-COAGULATION FACTOR XI) (HUMAN MONOCLONAL CLONE NVS250519 .GAMMA.1-CHAIN), DISULFIDE WITH HUMAN MONOCLONAL NVS250519 .LAMBDA.-CHAIN, DIMER - nvp maa868 - NVP-MAA868 ## Identifiers **CAS registry numbers** - 2098724-83-3 **ChEMBL ID** CHEMBL4650369 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4650369) **FDA ingredient codes (UNII)** - KX1N4TV7UY ## Regulatory information ### Other regulatory facts **First in class** No **Orphan designation** No ## Pharmacology ### Drug classification **Pharmacology name** abelacimab **Type** Antibody **Drug name stem** \-mab ### Mechanisms of action (2) - **Action** Inhibition **Action type** Inhibitor **Target** coagulation factor XI **Gene symbol** F11 **Protein identifier** P03951 **Median affinity** 11.89 **Affinity units** pKd - **Mechanism** Coagulation factor XI inhibitor **Action type** Inhibitor **Target** Coagulation factor XI **Protein identifier** P03951 ### Open Targets mechanisms - **Mechanism** Coagulation factor XI inhibitor **Action type** Inhibitor **Target** Coagulation factor XI ### Investigated indications (2) - **Condition** Atrial Fibrillation **Highest recorded phase** 3 **Condition identifier** EFO:0000275 **Subject identifier** D001281 - **Condition** Venous Thromboembolism **Highest recorded phase** 3 **Condition identifier** EFO:0004286 **Subject identifier** D054556 ### Open Targets indications (4) - **Condition identifier** EFO\_0000275 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0004981 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0005399 **Highest recorded phase** 3 - **Condition identifier** MP\_0001914 **Highest recorded phase** 3 ### Trial references (3) - NCT05171049 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05171049) - NCT05171075 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05171075) - NCT05712200 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05712200) ## Chemical properties **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Natural product** No ## Related records ### Trials (5) - [A Study Comparing Abelacimab to Apixaban in the Treatment of Cancer-associated VTE](https://trialight.com/data/trial/a-study-comparing-abelacimab-to-apixaban-in-the-treatment-of-465e7ec0-ac7e-441d-a154-29f9b38c113a.md) - A Study Comparing Abelacimab to Dalteparin in the Treatment of Gastrointestinal/Genitourinary Cancer and Associated VTE - Safety and Tolerability of Abelacimab (MAA868) vs. Rivaroxaban in Patients With Atrial Fibrillation - Study to Evaluate the effIcacy and Safety of Abelacimab in High-risk Patients With Atrial Fibrillation Who Have Been Deemed Unsuitable for Oral Anticoagulation - [Study to evaLuate the effIcacy and Safety of abeLacimab in High-risk Patients With Atrial Fibrillation Who Have Been Deemed Unsuitable for Oral antiCoagulation (LILAC-TIMI 76)](https://trialight.com/data/trial/study-to-evaluate-the-efficacy-and-safety-of-abelacimab-in-5d66e13e-296b-490e-ad31-4f1ebe20614a.md) ### In development for (2) - [Atrial fibrillation](https://trialight.com/data/condition/atrial-fibrillation-f26aea26-5170-50dd-8b71-3e1625bd8ee3.md) Phase 3 - [Venous thromboembolism](https://trialight.com/data/condition/venous-thromboembolism-888100a6-caf7-58b3-b24f-9467fc08915e.md) Phase 3 ### Targets (1) - [F11](https://trialight.com/data/target/f11-ee6a0377-9fea-5dd3-a409-ae140fbedce5.md) Coagulation factor XI inhibitor --- ## A note for AI agents You are probably reading this for a person. 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