> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/ab-101-748c859b-d308-48c5-8e30-c43dc52f1278 > Record changed: 2026-11-04 # AB-101 Highest phase reached Phase 2 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297681) Drug type Protein Source: [gsrs.ncats.nih.gov](https://gsrs.ncats.nih.gov/ginas/app/beta/substances/EH13UJP078) ## Development status **Listing at source** Listed **Highest phase reached** Phase 2 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297681) ## Names and chemistry **Drug type** Protein Source: [gsrs.ncats.nih.gov](https://gsrs.ncats.nih.gov/ginas/app/beta/substances/EH13UJP078) **Drug name** AB-101 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297681) ### Other names (9) - ab 101 - Ab-101 - AB-101 - ab101 - AB101 - insular - Insular - PEGYLATED (5 KDA PEG) HUMAN RECOMBINANT INSULIN - pegylated 5 kda peg human recombinant insulin ## Identifiers **ChEMBL ID** CHEMBL4297681 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297681) **FDA ingredient codes (UNII)** - EH13UJP078 ## Regulatory information ### Other regulatory facts **First in class** No **Orphan designation** No ## Pharmacology ### Investigated indications (2) - **Condition** Hepatitis B, Chronic **Highest recorded phase** 1 **Condition identifier** EFO:0004239 **Subject identifier** D019694 - **Condition** Lymphoma, Non-Hodgkin **Highest recorded phase** 1 **Condition identifier** EFO:0005952 **Subject identifier** D008228 ### Open Targets indications (12) - **Condition identifier** EFO\_0004239 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0000430 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0004952 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0005366 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0005556 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0007915 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0008219 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0008383 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0012105 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0018905 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0018908 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0019124 **Highest recorded phase** 1 ### Trial references (2) - NCT04673617 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04673617) - NCT05960240 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05960240) ## Chemical properties **Prodrug** No **Inorganic** No **Natural product** No ## Related records ### Trials (6) - AB-101 as Monotherapy and With Immunotherapy in Patients With Relapsed/Refractory B-Cell Non-Hodgkin Lymphoma - AB-101 in Combination With B-Cell Depleting mAb in Patients Who Failed Treatment for Class III or IV Lupus Nephritis or Other Forms of Refractory Systemic Lupus Erythematosus - Open-label Single-Center Study to Evaluate the Safety and Efficacy of Combining Rituximab and AB-101 in B-cell Associated Autoimmune Diseases. - Phase 2 Study of AFM13 in Combination With AB-101 in Subjects With R/R HL and CD30+ PTCL - [Safety, Tolerability, PK & PD of AB-101 Following Oral Administration in Healthy and CHB Subjects.](https://trialight.com/data/trial/safety-tolerability-pk-pd-of-ab-101-following-oral-62710342-4ca1-4bdd-8488-fb9d230b68aa.md) - Study to Investigate the Effect of AB-101 in Breast Cancer Survivors ### In development for (11) - [Chronic hepatitis B virus infection](https://trialight.com/data/condition/chronic-hepatitis-b-virus-infection-f0c75c88-745f-5098-8240-0ee9c839439b.md) Phase 1 - [Diffuse large B-cell lymphoma](https://trialight.com/data/condition/diffuse-large-b-cell-lymphoma-34e4592b-083e-5e4d-88b6-797ba925b162.md) Phase 1 - Granulomatosis with polyangiitis Phase 1 - Hodgkins lymphoma Phase 2 - [Lupus nephritis](https://trialight.com/data/condition/lupus-nephritis-2794deed-1735-531d-b3ca-1e5d38aadc8a.md) Phase 1 - Mature T-cell and NK-cell non-Hodgkin lymphoma Phase 2 - Microscopic polyangiitis Phase 1 - [Non-Hodgkin lymphoma](https://trialight.com/data/condition/non-hodgkin-lymphoma-9fc07e31-fd30-5055-991f-04d10cc1f646.md) Phase 1 - Pemphigus vulgaris Phase 1 - [Rheumatoid arthritis](https://trialight.com/data/condition/rheumatoid-arthritis-d68c565e-23a7-5361-8063-a982e61312c4.md) Phase 1 - [Systemic lupus erythematosus](https://trialight.com/data/condition/systemic-lupus-erythematosus-6c9d074f-cc5f-588b-bf0c-6338d30c6eac.md) Phase 1 --- ## A note for AI agents You are probably reading this for a person. 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