> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/1018-iss-911ee104-bf1a-4263-a7e1-743a42d4d654 > Record changed: 2026-10-13 # 1018 ISS Highest phase reached Phase 3 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297680) Drug type Oligonucleotide Source: [gsrs.ncats.nih.gov](https://gsrs.ncats.nih.gov/ginas/app/beta/substances/25DT549L0G) ## Development status **Listing at source** Listed **Highest phase reached** Phase 3 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297680) ## Names and chemistry **Drug type** Oligonucleotide Source: [gsrs.ncats.nih.gov](https://gsrs.ncats.nih.gov/ginas/app/beta/substances/25DT549L0G) **Drug name** 1018 ISS Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297680) ### Other names (18) - 1018 iss - 1018 ISS - 1018 ISS \[WHO-DD\] - 1018 iss who dd - cpg 1018 - Cpg 1018 - CpG 1018 - CpG 1018® - cpg oligonucleotide 1018 iss - Cpg oligonucleotide 1018 iss - CPG-1018 - dna d p thio t g a c t g t g a a c g t t c g a g a t g a - DNA, D(P-THIO)(T-G-A-C-T-G-T-G-A-A-C-G-T-T-C-G-A-G-A-T-G-A) - iss 1018 - Iss 1018 - iss 1018 cpg oligodeoxynucleotide - Iss 1018 cpg oligodeoxynucleotide - Iss-1018 ## Identifiers **CAS registry numbers** - 937402-51-2 **ChEMBL ID** CHEMBL4297680 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297680) **FDA ingredient codes (UNII)** - 25DT549L0G ## Regulatory information ### Other regulatory facts **First in class** No **Orphan designation** No ## Pharmacology ### Mechanisms of action - **Mechanism** Toll-like receptor 9 agonist **Action type** Agonist **Target** Toll-like receptor 9 **Protein identifier** Q9NR96 ### Open Targets mechanisms - **Mechanism** Toll-like receptor 9 agonist **Action type** Agonist **Target** Toll-like receptor 9 ### Investigated indications (5) - **Condition** HIV Infections **Highest recorded phase** 1 **Condition identifier** EFO:0000764 **Subject identifier** D015658 - **Condition** Colorectal Neoplasms **Highest recorded phase** 1 **Condition identifier** EFO:0004142 **Subject identifier** D015179 - **Condition** Hepatitis B, Chronic **Highest recorded phase** 2 **Condition identifier** EFO:0004197 **Subject identifier** D019694 - **Condition** Lymphoma, Non-Hodgkin **Highest recorded phase** 2 **Condition identifier** EFO:0005952 **Subject identifier** D008228 - **Condition** Severe Acute Respiratory Syndrome **Highest recorded phase** 3 **Condition identifier** MONDO:0100096 **Subject identifier** D045169 ### Open Targets indications (7) - **Condition identifier** EFO\_0000574 **Highest recorded phase** 3 - **Condition identifier** EFO\_0004142 **Highest recorded phase** 1 - **Condition identifier** EFO\_0004197 **Highest recorded phase** 2 - **Condition identifier** EFO\_0005952 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0005062 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0005575 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0100096 **Highest recorded phase** 3 ### Trial references (8) - NCT00251394 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00251394) - NCT00403052 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00403052) - NCT00426712 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00426712) - NCT00498212 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00498212) - NCT04177355 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04177355) - NCT04405908 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04405908) - NCT04672395 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04672395) - NCT05012787 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05012787) ## Chemical properties **Prodrug** No **Inorganic** No **Natural product** No ## Related records ### Trials (9) - A Controlled Phase 2/3 Study of Adjuvanted Recombinant SARS-CoV-2 Trimeric S-protein Vaccine (SCB-2019) for the Prevention of COVID-19 - A Safety and Efficacy Study of a Single or Double Dose of HEPLISAV™ Hepatitis B Vaccine in Adults With End-Stage Renal Disease - A Study of 1018 Immunostimulatory Sequence (ISS) Administered With Irinotecan and Cetuximab to Treat Patients With Previously Treated Metastatic Colorectal Cancer - Evaluating the Safety and Immunogenicity of HIV-1 BG505 SOSIP.664 gp140 With TLR Agonist and/or Alum Adjuvants in Healthy, HIV-uninfected Adults - [Phase 1 Trial to Assess the Safety and Immunogenicity of an Inactivated, Adjuvanted Whole Zika Virus Vaccine Candidate (VLA1601) in Healthy Adults](https://trialight.com/data/trial/phase-1-trial-to-assess-the-safety-and-immunogenicity-of-an-6079fa6b-39a7-4001-ab73-af233882a0e5.md) - Safety and Immunogenicity of Adjuvanted SARS-CoV-2 (SCB-2019) Vaccine in Adults With Chronic Immune-Mediated Diseases - Safety of HEPLISAV™ Hepatitis B Virus Vaccine in End-stage Kidney Failure Patients - SCB-2019 as COVID-19 Vaccine - Study of Dynavax's 1018 ISS, Following Rituxan in Patients With B-Cell Follicular Lymphoma ### In development for (6) - [Colorectal neoplasm](https://trialight.com/data/condition/colorectal-neoplasm-31f0a633-3abe-5df4-9d3a-9292c6541f1d.md) Phase 1 - [COVID-19](https://trialight.com/data/condition/covid-19-13f0ebf3-c291-557d-bdef-93563d077103.md) Phase 3 - [Hepatitis B virus infection](https://trialight.com/data/condition/hepatitis-b-virus-infection-63cb6d13-50c4-5e97-86fd-ce5481d9d1c6.md) Phase 2 - [HIV infectious disease](https://trialight.com/data/condition/hiv-infectious-disease-1260f28c-d667-55f9-b221-15d5017fde05.md) Phase 1 - [Lymphoma](https://trialight.com/data/condition/lymphoma-de4db685-7419-5e0e-b958-4591ffd69d43.md) Phase 3 - [Non-Hodgkin lymphoma](https://trialight.com/data/condition/non-hodgkin-lymphoma-9fc07e31-fd30-5055-991f-04d10cc1f646.md) Phase 2 ### Targets (1) - [TLR9](https://trialight.com/data/target/tlr9-44bcb4f7-bea0-55ea-b4de-03f1b54cebeb.md) Toll-like receptor 9 agonist --- ## A note for AI agents You are probably reading this for a person. 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